VII - Topnotch Pharma Flash Cards - Chemotherapeutic Drugs Preview

Pharmacology > VII - Topnotch Pharma Flash Cards - Chemotherapeutic Drugs > Flashcards

Flashcards in VII - Topnotch Pharma Flash Cards - Chemotherapeutic Drugs Deck (225)
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181

DOC for hookworm and roundworm infections

Pyrantel pamoate (TOPNOTCH)

182

DOC for trichinosis

Thiabendazole (TOPNOTCH)

183

DOC for trematodes (schistosoma, paragonimus, clonorchis, opistorchis) and cestodes (taenia, diphyllobothrium)

Praziquantel (TOPNOTCH)

184

Used with steroid when treating neurocysticercosis, contraindicated in ocular cysticercosis (may cause irreparable eye damage)

Praziquantel (TOPNOTCH)

185

Increases membrane permeability to calcium, cause muscle paralysis, vacualization and death

Praziquantel (TOPNOTCH)

186

Uncouples oxidative phosphorylation or by activating ATPases ; alternative drug for cestode infection (Taenia, diphyllobotrium)

Niclosamide (TOPNOTCH)

187

Forms DNA cross-links, resulting in inhibition of DNA synthesis and function, Cell-cycle nonspecific

Alkylating agents (TOPNOTCH)

188

Alkylating agents

Cyclophosphamide, chlorambucil, Cisplatin, Carboplatin, oxaliplatin, Procarbazine, Dacarbazine, Busulfan, Carmustine, lomustine (TOPNOTCH)

189

SE: bone marrow suppression, hemorrhagic cystitis, hepatotoxicity, alopecia, SIADH, pulmonary toxicity

Cyclophosphamide (TOPNOTCH)

190

Rescue therapy for cyclophosphamide

MESNA (TOPNOTCH)

191

Rescue therapy for Cisplatin

Amifostine (TOPNOTCH)

192

can penetrate the CSF, For Hodgkin's lymphoma, non-hodgkin's lymphoma, brain tumors

Procarbazine (TOPNOTCH)

193

SE: pulmonary fibrosis, adrenal insufficiency, skin pigmentation

Busulfan (TOPNOTCH)

194

Highly lipophilic allowing ease of passage through BBB into the CNS ; For brain tumors, melanoma, skin cancer

Carmustine, lomustine (TOPNOTCH)

195

Inhibits dihydrofolate reductase, decreases synthesis of thymidylate, amino acids, purine nucleotides; cell cycle specific

Methotrexate (TOPNOTCH)

196

Rescue therapy for methotrexate

Leucovorin (Folinic acid) (TOPNOTCH)

197

Inhibits de novo purine nucleotide synthesis, activated by HGPRT, cell cycle specific ; For acute leukemia (AML, ALL), CML

6-Mercaptopurine, 6-thioguanine, fludarabine, cladribine (TOPNOTCH)

198

Inhibits thymidylate synthase, causes thymineless death of cells, cell cycle specific

5-Fluorouracil (TOPNOTCH)

199

a deoxycytidine analog

Gemcitabine (TOPNOTCH)

200

Most specific for the S-phase of the cell cycle

Cytarabine (TOPNOTCH)

201

Prevents microtubule assembly, causes cell arrest at metaphase, cell cycle specific

Vinca alkaloid: Vincristine, Vinblastine (TOPNOTCH)

202

Inhibits DNA topoisomerase II, inhibits mitochondrial electron transport, cell cycle specific

Etoposide (TOPNOTCH)

203

Inhibits DNA topoisomerase I, cell cycle specific; For advanced ovarian cancer (2nd line), small cell lung cancer

Topotecan, irinotecan (TOPNOTCH)

204

Interferes with mitotic spindle, prevents microtubule disassembly into tubulin monomers, cell cycle specific

Paclitaxel, docetaxel (TOPNOTCH)

205

used in solid tumors like breast, ovarian, lung, gastroesophageal, prostate, bladder and head & neck cancers

Paclitaxel, docetaxel (TOPNOTCH)

206

Acts primarily in M phase of cancer cell cycle

Vinca alkaloid: Vincristine, Vinblastine (TOPNOTCH)

207

Intercalates between base pairs, inhibits topoisomerase II, generates free radicals cell cycle non-specific

Anthracycline: Doxorubicin, daunorubicin, idarubicin, epirubicin, mitoxantrone (TOPNOTCH)

208

Rescue therapy for Doxorubicin

dexrazoxane (TOPNOTCH)

209

Most specific for the G2 phase of cell cycle

Bleomycin (TOPNOTCH)

210

SE: pneumonitis, pulmonary fibrosis, alopecia, mucocutaneous reactions

Bleomycin (TOPNOTCH)