VII - Topnotch Pharma Flash Cards - Chemotherapeutic Drugs Preview

Pharmacology > VII - Topnotch Pharma Flash Cards - Chemotherapeutic Drugs > Flashcards

Flashcards in VII - Topnotch Pharma Flash Cards - Chemotherapeutic Drugs Deck (225)
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211

Binds to double stranded DNA, inhibits DNA-dependent RNA synthesis, cell cycle non-specific

Actinomycin D (TOPNOTCH)

212

Tyrosine kinase inhibitor of the protein product of bcr-abl oncogene in CML ; For CML, GIST

TK inhibitor: Imatinib, dasatinib, nilotinib (TOPNOTCH)

213

recognizes a surface protein in breast CA cells that overexpress Her-2-Neu receptors for epidermal growth factor

Trastuzumab (TOPNOTCH)

214

Inhibits binding of VEGF to VEGFR leading to inhibiton of VEGF signalling, inhibits tumor vascular permeability but enhances tumor blood flow and drug delivery

Bevacizumab (TOPNOTCH)

215

Binds to a surface protein in NHL cells, induces complement-mediated lysis, direct cytotoxicity and induction of apoptosis

Rituximab (TOPNOTCH)

216

Endogenous glycoproteins with antineoplastric, immunosuppressive and antiviral actions

Interferon alpha (TOPNOTCH)

217

Depletes serum asparagines ; For ALL, T-cell auxotrophic CA (leukemia and lymphomas) that require asparagine for growth

Asparaginase (TOPNOTCH)

218

Only vitamin that can cure cancer

All-Trans retinoic acid (TOPNOTCH)

219

For acute promyelocytic leukemia

All-Trans retinoic acid (TOPNOTCH)

220

Suppresses inflammation and immune response, may trigger apoptosis and work on nondividing cancer cells

Prednisone (TOPNOTCH)

221

Estrogen antagonist actions in breasts tissue and CNS, estrogen agonist effects in uterus, liver and bone

Tamoxifen (TOPNOTCH)

222

Androgen antagonist ; For prostate cancer

Flutamide (TOPNOTCH)

223

Increased LH, FSH secretion with intermittent administration, reduced LH and FSH secretion with prolonged continuous administration ; For prostate cancer

Leuprolide (TOPNOTCH)

224

Reduces estrogen synthesis by inhibiting aromatase; For breast cancer

Anastrazole (TOPNOTCH)

225

Effective againsts breast cancer that have become resistant to tamoxifen

Anastrazole (TOPNOTCH)