Viral Hem. fevers

Question 1

Dengue Hemorrhagic Fever 1) (virology) of Flaviridae family

Answer 1

1) + sense, ssRNA enveloped

Question 2

All Hemorrhagic fevers pathogenesis: 1) gets infected by virus, which then acts on lymphocytes, and causes apoptosis, etc.

Answer 2

Macrophages

Question 3

Marburg Hemorrhagic Fever pathogenesis: Macrophages release cytokines such as 1) which leads to DIC and hemorrhage

Answer 3

1) TNF-alpha, Tissure factor, and IL-6

Question 4

Sequential infections increase risk of hemorrhage

Answer 4

Dengue Hemorrhagic Fever

Question 5

All viral hemorrhagic fevers have some symptoms in common:

Answer 5

Hypotension, shock; multi-system organ failure

Question 6

The virus infecting dendritic cells, macrophages, hepatoctyes and adrenal cortical cells.

Answer 6

Marburg Hemorrhagic Fever

Question 7

Progresses to severe bruising, severe nosebleeds, and uncontrolled bleeding at injection sites

Answer 7

Crimean-Congo Hemorrhagic Fever

Question 8

Treatment – Avoid aspirin

Answer 8

Dengue Hemorrhagic Fever

Question 9

Ebola Hemorrhagic Fever pathogenesis: Virus infects macrophages and monocytes which leads to decreased 1), which are anti-virals; also INC. TNF, and tissue factor leading to 2);

Answer 9

1) IFN-alpha and IFN-beta 2) hemorrhage

Question 10

Nairovius causes 1); this virus has 2) viral segments; the largest one is the 3) segment which has nuclear proteins and ribonuclear capsid and polymerase

Answer 10

Crimean-Congo Hemorrhagic Fever; 2) three 3) L segment

Question 11

reservoir and vector Crimean-Congo Hemorrhagic Fever

Answer 11

Hyalomma tick

Question 12

West Africa including Sierra Leone, Liberia, Guinea and Nigeria

Answer 12

Lassa fever

Question 13

Enveloped – sense RNA virus of Arenaviridae family

Answer 13

Lassa fever

Question 14

Eastern Europe, NW China, central Asia, southern Europe, Africa, Middle East, Indian subcontinent

Answer 14

Crimean-Congo Hemorrhagic Fever

Question 15

Human-to-human from contact with infected blood or body fluids

Answer 15

Crimean-Congo Hemorrhagic Fever Ebola Hemorrhagic Fever Marburg Hemorrhagic Fever

Question 16

• + sense, ssRNA enveloped virus of Flaviridae family • 4 viral serotypes–>Not cross-protective

Answer 16

Dengue Hemorrhagic Fever

Question 17

vomiting with petechiae on the palate

Answer 17

Crimean-Congo Hemorrhagic Fever

Question 18

Ebolavirus part of 1) family; Virology 2)

Answer 18

Filoviridae family 2) - sense ssRNA genome • Enveloped

Question 19

Marburg Hemorrhagic Fever Reservoir

Answer 19

African fruit bat, Rousettus aegyptiacus;

Question 20

1) = Filoviridae family • - sense ssRNA genome • Enveloped • 2 species

Answer 20

Marburgvirus

Question 21

Ingestion or inhalation of infected rat urine or feces

Answer 21

Lassa fever

Question 22

Lasts about 2 weeks

Answer 22

Crimean-Congo Hemorrhagic Fever

Question 23

Dengue Hemorrhagic Fever–> virus has 4 viral serotypes that are NOT cross reactive; what does this mean?

Answer 23

so if get infected by type 1, can still get infected by types 2, 3 and 4

Question 24

deafness

Answer 24

Lassa fever

Question 25

Dengue Hemorrhagic Fever pathogenesis: Infection occurs in a 1), which produces many cytokines; this leads to activation of 2), which produce IFN-gamma; 1) can also produce IL-12, IL-8, and IL-1beta leading to 3). Other manifestations are Hypotension and shock;

Answer 25

1) monocyte or dendritic cell; 2) Natural killer cells; 3) DIC

Question 26

Fever (greater than 38.6°C=101.5 F); Unexplained hemorrhage; General symptoms such as muscle pain, weakness, diarrhea

Answer 26

Ebola Hemorrhagic Fever

Question 27

Virus infecting monocytes, macrophages and interacting with neutrophils and natural killer cells; leads to Natural killer cell depletion;

Answer 27

Ebola Hemorrhagic Fever

Question 28

Maculopapular rash on the trunk

Answer 28

Marburg Hemorrhagic Fever Reservoir

Question 29

Vector = Mastomys natalensis rat

Answer 29

Lassa fever

Question 30

Dengue Hemorrhagic Fever pathogenesis: 1) producing IL-12, IL1-beta and IL8 that result in interference w/ coagulation factors and resulting in platelet activation --\> thus DIC and other hemorrhagic manifestations

Answer 30

1) monocytes

Question 31

Severe multisystem syndrome often accompanied by hemorrhage; no cure

Answer 31

Viral Hemorrhagic Fevers

Question 32

Viral Hemorrhagic Fevers caused by:

Answer 32

enveloped, ssRNA viruses

Question 33

three viral segments: (a) L segment, which is the longest and largest segment, which is attached and tethered to the polymerase as well as has nuclear proteins and the ribonuclear capsid (b) M segment (c) S segment

Answer 33

Nairovirus

Question 34

80% of infections are mild and undiagnosed 20% = hemorrhaging (in gums, eyes, or nose)

Answer 34

Lassa fever

Question 35

Sudden onset of headache, high fever, back pain, joint pain, stomach pain and vomiting with petechiae on the palate • Red eyes, flushed face, and red throat

Answer 35

Crimean-Congo Hemorrhagic Fever

Question 36

Greatest risk = healthcare workers, family, close friends

Answer 36

Ebola Hemorrhagic Fever

Question 37

Symptoms appear at an average of 8-10 days, but can be as long as 21 days

Answer 37

Ebola Hemorrhagic Fever

Question 38

Crimean-Congo Hemorrhagic Fever: 1) – member of Bunyaviridae family • 2) genome

Answer 38

1) Nairovirus 2) (-) sense ssRNA

Question 39

Marburg Hemorrhagic Fever pathogenesis: virus affects 1) which leads to hypotension, shock, and multiorgan failure

Answer 39

ADRENAL cortical cells

Question 40

Red eyes, flushed face, and red throat

Answer 40

Crimean-Congo Hemorrhagic Fever

Question 41

Fever, chills, headache, and myalgia early

Answer 41

Marburg Hemorrhagic Fever Reservoir

Question 42

Progresses to jaundice, severe weight loss, delirium, shock, massive hemorrhaging, and multi-organ dysfunction

Answer 42

Marburg Hemorrhagic Fever Reservoir

Question 43

Dengue Hemorrhagic Fever transmitted by:

Answer 43

Aedes aegypti and Aedes albopictus mosquitoes

Question 44

Facial swelling

Answer 44

Lassa fever

Question 45

First patient in outbreak associated with contact with blood of infected animal (bats) or bushmeat

Answer 45

Ebola Hemorrhagic Fever

Question 46

Crimean-Congo Hemorrhagic Fever Transmission through infected 1) or 2)

Answer 46

1) Hyalomma ticks 2) animal blood

Question 47

Skin symptoms: Rash, bruising, petechiae, and purpura

Answer 47

Dengue Hemorrhagic Fever