Flashcards in Viral STIs Deck (8)
What are the two major forms of HIV and where are they found?
HIV-2 West Africa
What is the HIV receptor and co-receptor?
CD4 binds to gp120
CCR5 binds to gp41 - allows fusion of envelopes
What are prognostic indicators of faster HIV disease progression?
Higher viral load and lower CD4+ T cell count
What are the routes of sexual HIV transmission?
Greater in women and MSM
Vaginal epithelium gets broken
Endocervical cells (ectopy)
Rectal simple columnar epithelium is easy damaged and has lymphocitic infiltrate
Internal prepuse not keratinized
When is HIV transmission more likely?
Acute phase and stage 3 - high viral loads
What are symptoms of acute HIV infection?
Flu like symptoms
How do you diagnose HIV?
HIV ab ELISA
Western blot of all HIV proteins