Reproductive Endocrinology Flashcards Preview

Module 6: Repro/Endocrine > Reproductive Endocrinology > Flashcards

Flashcards in Reproductive Endocrinology Deck (11)

What causes testicular feminization?

Genetic male that phenotypically looks female due to androgen insensitivity

- Deficiency of 5a-reductase is most common cause

--> Absence of Testosterone and Mullerian inhibiting Substance permits female pattern to develop although abdominal testes will be present

--> cannot activate testosterone, therefore, external virilization and male sexual maturation at puberty do not occur


What causes congenital adrenal hyperplasia?

21-Hydroxylase Deficiency

--> Aldosterone and cortisol cannot be produced, due to hydroxylase deficiency.  therefore, no ACTH negative biofeedback occurs resulting in increased androgen production

--> Results in masculinity of genetic females


What is gonadarche?

Activation of gonadal functions

-> Cause: GnRH driven pituitary LH/FSH secretion


What is Thelarche?

Breast Development

- Cause: ovarian estrogen


What is adrenarche?

Activation of adrenal androgen secretion causing the appearance of pubic and axillary hair
- includes changels in sweat glands and composition of sweat leading to adult body odor

- Cause: uncertain - ot ACTH or gonadotropin mediated


What is peripherial vs central precocious puberty?

Peripheral: caused by source of androgens outside of brain hormone release

Central: Due to increased release of LH by pituitary gland


How does testing LH help determine peripheral vs central precocious puberty?

Normal = rules out "precocious" puberty
interpretation: normal development for this child

High = central precocious puberty
treatment: suppression of HPG axis with super active GnRH analogs

Low = peripheral precocious puberty
treatment: identify source of sex steroids (adrenal, Rx, diet) and treat accordingly


What are causes of central precocious puberty?

- Tumors (astrocytomas, gliomas, germ cell tumors secreting HCG)

- Hypothalamic hamartomas

- Acquired CNS injury caused by inflammation, surgery, trauma, radiation therapy, or abcess

- Congenital anomalies (i.e. hydrocephalus, arachnoid cysts, suprasellar cysts)


What are the components of the adenohypophysis?

AKA anterior lobe of pituitary

Pars tuberalis

Pars distalis (pars anterior)

Pars intermedia


What are the components of teh neurohypophysis?

AKA posterior lobe of pituitary

Pars nervosa (infundibular process)

Infundibulum (neural stalk)