Virology 1

Question 1

Viruses containing reverse transcriptase

Answer 1

Hepadna

retro virus

Question 2

Circular DNA viruses

Answer 2

Hepadna
papilloma
polyoma

Question 3

Unilateral middle ear effusion shows?

Answer 3

Eustachian tube blockade by nasopharyngeal carcinoma

Question 4

In contrast to toxoplasmosis brain lesion in JC virus is?

Answer 4

Non-Enhancing multifocal

Question 5

Parvo virus B19 infects which cells?

Answer 5

RBC precursors

Endothelial cells

Question 6

Pronormoblast is?

Answer 6

several times larger than surrounding RBCs, with glassy, intranuclear viral inclusions.

Question 7

Pronormoblast is formed by?

Answer 7

infection of progenitor RBCs with Parvo virus B19

Question 8

Recent Parvo virus B19 infection is confirmed by?

Answer 8

anti-B19 IgM in serum

Question 9

Meningitis is caused by which HSV?

Answer 9

HSV 2

Question 10

HSV 1 infects the temporat lobe by entry through?

Answer 10

Olfactory tract to olfactory cortex in medial temporal lobe

Question 11

Most common reason for hospitalization in children with HSV-1 gingivostomatitis is?

Answer 11

Dehydration (refusal to drink)

Question 12

Neonatal HSV (fever and seizures in newborn period) caused by?

Answer 12

HSV-2

Question 13

Severity of recurrence in HSV, Why?

Answer 13

Less severe, due to humoral immunity

Question 14

HSV patient is more contagious during?

Answer 14

Recurrance

Question 15

Difference in painful vesicular rash b/w HSV and VZV?

Answer 15

HSV: Bilateral
VZV: Unilateral, in dermatome without systemic involvement

Question 16

Docosanol?

Answer 16

Topical agent for herpes labialis, prevents viral entry.

Question 17

HSV diagnosed by?

Answer 17

1. PCR of CSF
2. Tzank smear
3. Direct fluorescence antibody

Question 18

Herpes zoster oticus

Answer 18

Ramsay hunt syndrome

Facial nerve involvement: Bell’s palsy, ear pain, vesicles in external auditory meatus

Question 19

Hemorrhagic inflammation of dorsal root ganglion and peripheral nerve is caused by?

this leads to?

Answer 19

Reactivation of VZV

neuropathic pain: herpetic neuralgia

Question 20

Capsaicin topical form. MOA?

Answer 20

Activation of TRPV1→ substance P depletion and long standing dysfunction of nociceptive nerve fibers (build up of intracellular Ca→ Dysfunctionalization of nociceptive nerve fibers)

Question 21

Primary CNS lymphoma ; most common subtype?

Answer 21

Diffuse large B-cell

Question 22

Oncogenic viral proteins of EBV?

their purpose?

Answer 22

EBNA-1 LMP-1
used by virus to keep remain latent in memory B cells to prevent from apoptosis. This also converts premalignant lesion into nasopharyngeal cancer

Question 23

Monospot test is negative in initial EBV infection, what should we do next?
What else it suggests

Answer 23

Repeat it

CMV is possible cause of IM

Question 24

Blueberry muffin rash is due to underlying…

Answer 24

thrombocytopenia

Extramedullary hematopoiesis

Question 25

CMV remains latent in?

Answer 25

Mono-nuclear cells (B, T lymphocytes and Macrophages)

Question 26

Highest risk g congenital CMV in?

Answer 26

2nd trimester

Question 27

Roseola Infantum (Exanthem subitum) infects which cells?

Answer 27

CD4 T cells

Question 28

Most common tumor in HIV+ patients?

Answer 28

Kaposi sarcoma

Question 29

Atypical lymphocytes are.......... by virus. They .......... to infected cells.

Answer 29

not infected, react

Question 30

All positive sense RNA viruses are icosahedral, except?

Answer 30

Corona virus

Question 31

Herpangina: Caused by? Presentation?

Answer 31

Coxsackie Virus Fever + Herpes like but spares anterior mouth and involves posterior pharyngeal wall, tongue, soft palate. Vesicles without rash.

Question 32

Coxsackie Virus oral .......... skin ..........

Answer 32

Enanthem | Exanthem

Question 33

All -ve sense RNA virus has? (capsid symmetry)

Answer 33

Helical

Question 34

Paramyxo viruses contain protein F (fusion) that causes.......... to fuse and form.......?

Answer 34

respiratory epithelial cells, | multinucleated cells

Question 35

Bronchiolitis: Cause? | Presentation?

Answer 35

RSV ♦ Antecedent 1. nasal congestion/discharge 2. Cough ♦ 1. Diffuse wheeze/crackles 2. Respiratory distress (tachypnea, retractions, nasal flaring)

Question 36

Pertussis lung auscultation?

Answer 36

Clear to auscultate

Question 37

Classic dengue fever presentation?

Answer 37

1. Flu like 2. myalgias & joint oain 3. retro porbital pain 4. Rash (white islands in red sea)

Question 38

Secondary infection with different strain of dengue presentation?

Answer 38

1. Maculopapular rash 2. Multiple pruritic lesions 3. Hepatomegaly 4. Thrombocytopenia, leukopenia

Question 39

Dengue hemorrhagic fever underlying cause?

Answer 39

1. ↑ vascular permeability (main cause) 2. thrombocytopenia <100,000 3. Spontaneous bleeding → shock

Question 40

Yellow fever liver biopsy?

Answer 40

Councilman bodies (eosinophilic apoptotic globules)