Virology Final Pathogenesis Facts

Question 1

African Swine Fever Virus tropism

Answer 1

monocytes/macrophages

Question 2

BHV-1 latency

Answer 2

tonsils, lymphoid tissue
trigeminal ganglion
sacral ganglion

Question 3

BHV-5 latency

Answer 3

trigeminal ganglion, midbrain, thalamus, olfactory nerve

Question 4

EHV-1 latency

Answer 4

trigeminal ganglion
lymphoid tissue

Question 5

EHV-3 latency

Answer 5

latent in sacral ganglion

Question 6

Pseudorabies Virus eradicated in what species? latency where?

Answer 6

eradicated in domestic swine
cranial nerve ganglion

Question 7

CHV-1 latency

Answer 7

sacral ganglion

Question 8

FHV-1 latency

Answer 8

trigeminal ganglion

Question 9

cervine adenovirus differential diagnostics

Answer 9

Epizootic Hemorrhage Disease
Malignant Catarrhal Fever

Question 10

Canine Parvovirus 2 tropism

Answer 10

myocardial cells
rapidly dividing cells

Question 11

Feline Panleukopenia Virus tropism

Answer 11

external granular layer of cerebellum

Question 12

Porcine Parvovirus often co-infected with ______

Answer 12

Porcine Circovirus 2

Question 13

CAV-1 and CAV-2

Answer 13

CAV-2 cross protective immunity for CAV-1, shed in urine = 2nd vx and herd immunity

Question 14

CPV-1 and CPV-2

Answer 14

genetically distinct
NO cross-protective immunity

Question 15

Bovine Papillomairus 1,2,3 tropism

Answer 15

keratinocytes and fibroblasts

Question 16

Bovine Papillomavirus 4,5,6 tropism

Answer 16

keratinocytes

Question 17

Equine Sarcoids often have _____ genomic sequences

Answer 17

BPV-1,2
horses are non-permissive host

Question 18

FeLV strains & tropism

Answer 18

A - horizontally transmittable
B - endogenous + A = recombinant strain
endogenous - non-pathogenic

lymphocytes, monocytes, salivary epithelium

Question 19

FIV tropism and strains

Answer 19

CD4/CD8 T cells
A & B most common, B less pathogenic

Question 20

Bovine Leukemia Virus tropism

Answer 20

B lymphocytes

Question 21

EIA tropism

Answer 21

macrophages

Question 22

Orbivirus tropism
Epizootic Hemorrhage Disease Virus
Blue Tongue Virus
African Horse Sickness Virus

Answer 22

reticuloendothelial cells (macrophages, dendritic cells)

Question 23

Infectious Bursal Disease Virus tropism

Answer 23

lymphotropic for B cells

Question 24

Rabies virus inclusion bodies

Answer 24

eosinophilic intracytoplasmic inclusion bodies “negri bodies”

Question 25

VSV tropism

Answer 25

epithelial cells

Question 26

Swine Influenza enzootic subtypes and sporadic subtypes

Answer 26

enzootic H1 and H3 sporadic H2,4,5,7,9

Question 27

Equine Influenza subtypes

Answer 27

H3N8 (A2) H7N7 (A1)

Question 28

Canine Influenza subtype

Answer 28

H3N8

Question 29

Rinderpest tropism

Answer 29

lymphocytes, macrophages, dendritic cells, endothelial cells

Question 30

Peste de Petitis Ruminant Virus has high mortality in ______

Answer 30

goats

Question 31

what stage of Avian Paramyxovirus-1 is used in the modified live vaccine? which is the most severe?

Answer 31

lentogenic - mild/subclinical most severe is viscerotropic velogenic

Question 32

Hendra virus tropism

Answer 32

endothelial cells

Question 33

Nipah virus tropism

Answer 33

endothelial cells & neurons

Question 34

Borna Disease Virus replications in what cells

Answer 34

neurons, astrocytes, oligodendrocytes "Joest-degen bodies"

Question 35

what makes Picornaviridae viruses (e.g. FMD) have high mutation rates

Answer 35

lack of RNA proof-reading

Question 36

FMD virus targets what cells

Answer 36

epithelial/keratinocytes

Question 37

West Nile Virus replicates in what cells

Answer 37

keratinocytes, Langerhans, Dendritc cells

Question 38

BVDV biotypes and cell tropism

Answer 38

non-cytopathic (most common) cytopathic (CPE) rapidly dividing cells - lymphocytes, monocytes, macrophages, epithelial cells

Question 39

classical swine fever virus tropism

Answer 39

monocytes, macrophages, endothelial

Question 40

equine arteritis virus tropism

Answer 40

macrophages, monocytes, lymphocytes

Question 41

Porcine Reproductive and Respiratory Syndrome Virus tropism

Answer 41

alveolar macrophages

Question 42

Porcine Respiratory Coronavirus mutant of ____

Answer 42

TGEV - deletion of E2 spike protein

Question 43

when did PEDV emerge in US

Answer 43

April 2013

Question 44

FIP mutant of _____ mutates in _____ replicates in ______

Answer 44

feline enteric coronavirus mutates in intestinal epithelium replicates in macrophages

Question 45

herpesvirus inclusion bodies

Answer 45

eosinophilic intranuclear inclusion bodies

Question 46

parvovirs inclusion bodies

Answer 46

intranuclear inclusion bodies

Question 47

reoviridae inclusion bodies

Answer 47

intracytoplasmic inclusion bodies

Question 48

Paramyxoviridae inclusion bodies

Answer 48

eosinophilic intracytoplasmic & intranuclear inclusion bodies