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Flashcards in Viruses Deck (65):
1

Live attenuated vaccines? (6)

Smallpox
Yellow f.
chicken pox (VZV)
Sabin's polio vaccine
MMR
Influenza (intranasal)

2

Killed vaccines? (4)

"RIP Always"
Rabies
Influenza (injected)
Salk Polio
HAV

3

Recombinant vaccine? (2)

HBV (recombinant HBsAg)
HPV (types 6, 11, 16, 18)

4

DNA viruses:
- Only ssDNA? (rest are dsDNA)
- 3 circulate? (rest are linear)

- Parvoviridea (part-of-a-virus)
- Papilloma-, polyoma-, hepadnaviruses

5

RNA viruses:
- Only dsRNA? (rest are ssRNA)
- (+) stranded RNA viruses? (7)

- Reoviridae (REpeat-O)
- Retrov., togav., flaviv., coronav., hepev., caliciv., picornav.

6

All viruses are haploid except?

Retroviruses, have 2 identical ssRNA (+) molec's

7

Naked DNA viruses?
Naked RNA viruses?

- PAPP = Papilloma, Adeno, Picorna, Polyoma
- CPR and hepevirus = Calci, Parvo, Reo, Hepevirus

8

Only env'd virus to get env from nuc mem instead of pl mem?

Herpesvirus

9

DNA viruses (7)
- strands are?
- DNA shape is?
- capsule shape is?
- rep where?

HHAPPPPy (usu ds, linear, icosahedral, rep in nuc)
Hepadna (circular, incomplete)
Herpes
Adeno
Pox (complex shape) (rep's in cytopl)
Parvo (ss-)
Papilloma (circular, supercoiled)
Polyoma (circular, supercoiled)

10

Herpesviruses:
env'd? genome? shape of genome? shape of virus? rep's in?

env'd, dsDNA, linear, icosahedral, rep's in nuc

11

HHV-3 =
-4 =
-5 =
-6 =
-7 =
-8 =

3=VZV
4=EBV
5=CMV
6=roseola
7=less common cause of roseola
8=Kaposi's

12

Hepadnavirus:
env'd? genome? shape of genome? shape of virus? rep's in?

env'd, dsDNA, partially circular, icosahedral, rep's in nuc

13

Which virus is not a retrovirus but still has RT?

HBV

14

Adenovirus:
env'd? genome? shape of genome? shape of virus? rep's in?

not env'd, dsDNA, linear, icosahedral, rep's in nuc

15

Adenovirus causes?

Febrile pharyngitis (sore throat, acute hemorrhagic cystitis)
Pneumo
Pink eye

16

Parvovirus:
env'd? genome? shape of genome? shape of virus? rep's in?

not env'd, ssDNA, linear (-), icosahedral, rep's in nuc

17

Parvovirus
- in fetus causes?
- in adults causes?

RBC destruc -> hydrops fetalis and death
- pure RBC aplasia, RA-like sx

18

Papillomavirus:
env'd? genome? shape of genome? shape of virus? rep's in?

not env'd, dsDNA, circular, icosahedral, rep's in nuc

19

Polyomavirus:
env'd? genome? shape of genome? shape of virus? rep's in?

not env'd, dsDNA, circular, icosahedral, rep's in nuc

20

Polyomavirus:
- 2 viruses?

- JC virus -> PML in HIV
- BK virus -> transplant pts, kidney dz

21

Poxvirus:
env'd? genome? shape of genome? shape of virus? rep's in?

env'd, dsDNA, linear, complex shape, rep's in cytopl (bc is biggest DNA virus)

22

CMV =
- latent in?
- causes?

HHV-5
- mononuc cells
- congenital infec, mononucleosis (neg Monospot), pneumo, retinitis

23

Roseola
- caused by?
- sx?
- usu in who?

HHV-6
- erythematous macules on soft palate 48hrs before rash -> high F xd's that can cause seizures -> diffuse macular rash
- infants

24

Herpes labialis presents as?
Herpes genitalis presents as?

- grouped/confluent vesicles w/ red rim
- ulcerating vesicles

25

Dx HSV by?

PCR
Tzanck test (multinuc'd giant cells)
See intranuc Cowdry A inclusions

26

4 sx of EBV mono?

F
HSM
pharyngitis
lymphadenopathy (esp post cervical LNs)

27

Reovirus:
env'd? genome? shape of genome? segments? shape of virus? causes?

no env, dsRNA, linear, 10-12 seg's, icosahedral (2x)
Coltivirus (arbov.) and Rotavirus

28

Picornavirus:
env'd? genome? shape of genome? segments? shape of virus? causes?

no env, ss(+)RNA, linear, 1seg, icosahedral
"PERCH" little one
- Polio, Echo, Rhino, Coxsackie, HAV

29

Hepevirus:
env'd? genome? shape of genome? segments? shape of virus? causes?

no env, ss(+)RNA, linear, 1seg, icosahedral
HEV

30

Calicivirus:
env'd? genome? shape of genome? segments? shape of virus? causes?

no env, ss(+)RNA, linear, 1seg, icosahedral
Norovirus

31

Flavivirus:
env'd? genome? shape of genome? segments? shape of virus? causes?

env'd, ss(+)RNA, linear, 1seg, icosahedral
HCV, Yellow F, Dengue, St. Louis encephalitis, West Nile virus
(all but HCV are arbov's)

32

Togavirus:
env'd? genome? shape of genome? segments? shape of virus? causes?

env'd, ss(+)RNA, linear, 1seg, icosahedral
Rubella, E/W equine encephalitis (arbov.)

33

Retrovirus:
env'd? genome? shape of genome? segments? shape of virus? causes?

env'd, ss(+)RNA, linear, 1seg, HTLV is complex, HIV is conical

34

Coronavirus:
env'd? genome? shape of genome? segments? shape of virus? causes?

env'd, ss(+)RNA, linear, 1seg, helical
Coronavirus and SARS

35

Orthomyxovirus:
env'd? genome? shape of genome? segments? shape of virus? causes?

env'd, ss(-)RNA, linear, 8 seg's, helical
Influenza virus

36

Paramyxovirus:
env'd? genome? shape of genome? segments? shape of virus? causes?

env'd, ss(-)RNA, linear, nonseg'd, helical
"PaRaMyxo"
Parainfluenza, RSV, Measles/Mumps

37

Rhabdovirus:
env'd? genome? shape of genome? segments? shape of virus? causes?

env'd, ss(-)RNA, linear, 1seg, helical
Rabies

38

Filovirus:
env'd? genome? shape of genome? segments? shape of virus? causes?

env'd, ss(-)RNA, linear, 1seg, helical
Ebola/Marburg hemorrhagic F

39

Arenavirus:
env'd? genome? shape of genome? segments? shape of virus? causes?

env'd, ss(-)RNA, circular, 2 seg's, helical
LCMV (lymphocytic choriomeningitis v.)
Lassa fever encephalitis (via mice)

40

Bunyavirus:
env'd? genome? shape of genome? segments? shape of virus? causes?

env'd, ss(-)RNA, circular, 3 seg's, helical
CA enceph, Sandfly/Rift Valley F's, Crimean-Congo hemorrhagic F, Hantavirus (hemorrhagic F, pneumo)
[all above except Hantav. are arbov's]

41

Delta virus:
env'd? genome? shape of genome? segments? shape of virus? causes?

env'd, ss(-)RNA, circula, 1 seg, uncertain shape
HDV (defective virus, needs HBV for co-infec)

42

Coltivirus =

Reovirus, causes Colorado tick F

43

Echovirus =

Picornavirus, causes aseptic meningitis

44

Coxsackievirus =

Picornavirus, causes aseptic meningitis, herpangina (mouth blisters, F), hand/foot/mouth dz, myocarditis

45

LCMV and Lassa fever encephalitis are what type of virus?

Arenaviruses

46

CA encephalitis is what type of virus?

Bunyavirus

47

Sandfly/Rift Valley fever is what type of virus?

Bunyavirus

48

Crimean-Congo hemorrhagic fever is what type of virus?

Bunyavirus

49

Hantavirus is what type of virus?

Bunyavirus

50

7 ss(-)RNA viruses?
All do/don't have env? All are what shape?

BOA F PR
Bunyavirus, Orthomyxobirus, Arenavirus, Flavivirus, Paramyxovirus, Rhabdovirus
- env'd bc carry own RNA-dep RNAP
- helical

51

4 seg'd viruses?

BOAR
Bunyavirus, Orthomyxovirus, Arenavirus, Reovirus
3, 8, 2, 10-12

52

Picornaviruses are?
- transmission?
- all except 2 can cause?

PERCH little one
Poliovirus, Echovirus, Rhinovirus, Coxsackievirus, HAV
- F/O except rhino (thus are enteroviruses) bc is acid-labile so killed in stomach
- aseptic meningitis (not rhino nor HAV)

53

Yellow fever =
- transmitted by?
- sx?

Flavivirus
- Aedes mosquitoes
- high F, blk V, jaundice

54

Rubella virus =
- sx?

Togavirus, aka German 3d measles
- RubelLA (rash, lymphadenopathy, arthritis) F, postauricular adenopathy, lymphadenopathy, arthralgias, fine non-confluent truncal rash that starts at head and moves down (spares hands and feet vs. measles which doesn't); see Forchheimer's spots on post palate at start of rash

55

Congenital rubella presents as?

3: PDA + cataracts + deafness +/- "blueberry muffin" rash
Also: sm head, retard, pulm stenosis (head, eyes, ears, heart)

56

Paramyxoviruses are?
All have what pr?

PaRaMyxo = Parainfluenza, RSV, Measles/Mumps
- surface F (fusion) pr -> causes resp epi cells to fuse and form multinuc'd cells (mAb to this, Palivizumab, prevents RSV pneumo in premature infants)

57

Viruses that cause polyarthritis in adults?

Rubella (arthralgias)
Parvovirus (RA-like sx)

58

Rubeola, aka?
- caused by?
- sx?
- sequelae?

Measles
- Measles virus
- Koplik spots (red w/ blue/white center) on buccal mucosa 1-2d before rash, descending maculopap rash (can be confluent), inc's hands/feet (unlike rubella)
- subacute sclerosing panencephalitis, encephalitis, giant cell pneumo

59

Confluent rash?
Non-confluent rash?
Koplik spots? when and where
Forchheimer's spots? when and where
Rash w/ seizures?

Rubeola (Measles virus)
Rubella
Rubeola/Measles (on buccal mucosa 1-2d before rash)
Rubella (on palate at start of rash)
Roseola (HHV-6), red macules on palate 48hrs before rash

60

3 C's of Measles =
Virus is aka?
- occurs when?

Rubeola:
Cough
Coryza (runny nose)
Conjunctivitis
- before rash (also blue-white Koplik spots on buccal mucosa)

61

Mumps =
causes?

Paramyxovirus
- POMpoms = Parotitis, Orchitis (inflamm of testes), aseptic Meningitis

62

HIV genes:
- Env =
- Gag =
- Pol =
- p17 =

- gp160 cleaved to gp120+gp41; 120 for attachment to CD4 Tcell, 41 is transmem pr for fusion and entry
- p24=capsid pr, contains 2 molec's of RNA
- RT, aspartate protease and integrase
- matrix pr

63

HIV binds what on T cells and on Mphage?

T cells: CCR5 early, or CXCR4 late coR + CD4
Mphage: CCR5 + CD4

64

AIDS infec's:
CD4 <50?

- Candida oral thrush
- Cryptosporidium D, JC react'n and PML, PCP
- Histo w/ HSM and tongue ulcer, Candida eso thrush, T. gondii brain abscesses,
- Cryoptococcus meningitis, CMV retinitis, MAC

65

Congenital CMV presents as?

Hearing loss, seizures, petechial rash, "blueberry muffin" rash (like w/ rubella)