Viruses/Prions Flashcards Preview

POM Exam 1 > Viruses/Prions > Flashcards

Flashcards in Viruses/Prions Deck (31):
1

4 components of a virus?

protein, nucleic acids, lipids, sugars

2

What is a virion?

entire virus particle

3

Envelope vs capsid?

envelope = external lipid membrane present in some viruses; capsid = all viruses have it, protein coat

4

What is a nucleocapsid?

some viruses have this special protein coat around nucleic acid

5

What is a capsomer?

Subunit that makes up a capsid

6

Protein coats can be ___ or ___ in shape? Which can hold more nucleic acid?

icosahedral or helical (open); helical has no theoretical limit to amount of DNA that can be packaged

7

mRNA would indicate a _____ sense strand

positive

8

Which sense strand can be immediately made into viral proteins?

positive

9

Which sense strand virus has to bring its own RNA dependent RNA polymerase?

negative

10

Which kind of viruses are more prone to errors, RNA or DNA?

RNA - no proofreading function so more mutable

11

Phases of viral replication kinetics?

Inoculation, eclipse, burst

12

Before uncoating in the cell, a virus must do what?

attach to cell membrane receptor and be taken into cell

13

What kinds of genes do viral genomes not possess?

Genes encoding protein synthesis machinery, energy metabolism, and membrane biosynthesis

14

What are the spikes you tend to see on enveloped viruses?

Glycoproteins that have been encoded in viral genome, can be used for docking to cell

15

GI tract pathogens - enveloped or nonenveloped?

Nonenveloped because acid destroys lipids

16

Naked viruses are more likely to be released in what manner?

Through lysis

17

Which viruses are more sensitive to heat, acids, and drying? Enveloped or naked?

Enveloped

18

5 ways that viruses can be categorized?

Virus family, disease process/site of infection, route of transmission, genome type, ability to establish latency

19

What way of categorizing viruses is most useful for public health measures?

By route of transmission!

20

Epstein Barr is from what family of viruses?

Herpesvirus

21

Are herpesviruses enveloped or naked? What kind of genome do they have?

enveloped; dsDNA

22

"Cold sores" are mostly associated with...

HSV1 (some HSV2)

23

VZV can reactivate as...

shingles

24

Which is more contagious, shingles or varicella?

varicella

25

Which viruses are associated with infectious mono?

Mostly EBV but also CMV

26

Genome of influenza A?

segmented RNA

27

Influenza A - enveloped or naked?

enveloped

28

Why is HIV called a retrovirus?

reverse transcriptase activity; RNA to DNA (integrated) to RNA again

29

2 main prion diseases in humans?

Kuru and CJD

30

Why do prion diseases produce spongiform encephalopathies?

plaque formation/accumulation in brain

31

Transmission of CJD is usually ____ or ____

iatrogenic or inherited