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Flashcards in viruses spreadsheet Deck (189)
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1

polio - virion structure

icosahedral (VP1/2/3, CD155 binding sites)

1

coronaviruses - virus types

SARS-associated coranaviruses; other coronaviruses

1

flavivirus - subclasses

hepacivirus, arboviruses

2

polio - how virus multiplies

Binds CD155 receptors

2

coronaviruses - enveloped; nucleic acid/structure; virion structure

enveloped; ss+RNA, one segment; helical

2

heacivirus - class, virus

flavivirus; hepatitis C

3

polio - transmission method

fecal-oral

3

coronaviruses – transmission method

airborne, possible others

3

hepatitus C -enveloped; nucleic acid/structure; virion structure

enveloped, +ssRNA, icosahedral

4

polio - general epidemiology
What season is polio infection the highest?
What is remarkable about polio and meningitis?
Does polio affect males or females more?
How fatal is polio?

seasonal infection (fall highest), leading cause of aseptic meningitis, infects males more often, rarely fatal

4

SARS-associated coronavirus - diseases caused

SARS

4

hepatitus C - transmission route

STD, needle sharing, blood transfusion, perinatal

5

polio - epidemiology
What percentage of polio patients become paralyzed?
What age group is most affected?

0.1-1% paralytic rate in older groups

5

other coronaviruses - diesases caused

common cold

5

hepatitus C - diseases caused

hepatitis C, hepatocellular carcinoma

6

polio - pathogenesis
What is the order of initial infection to shedding?
What lapse of the immune system causes paralytic polio?

Virus swallowed, multiplication in tonsils/Peyer's patches/ lymph nodes of SI and fecal-oral excretion of virus (route to next person via environment or hands), invasion of CNS (via viremia) in cases that cause paralysis, circulating Ab too late to prevent CNS invasion (paralysis occurs despite Ab)

6

coronaviruses - epidemiology

in adults, severity increases with age, case-fatality rate of 9%, first appeared in China then spread worldwide, but quarantine may have stopped spread

6

hepatitus C - general epidemiology

75% chronically infected, 20% develop cirrhosis or hepatocellular carcinoma 10-20 years after acture HCV infection… results in 10k dpy in US, 4 mil Americans chronically infected

7

polio - incubation period

2-3 weeks

7

coronaviruses - incubation period

2-10 days

7

hepatitus C - pathogenesis

CD8+ cells recognize HCV peptides presented by MHC I, kills hepatocytes (again higher chance of mutations), virus does not integrate into the genome

8

polio - signs and symptoms

Aseptic meningitis: H/A. stiff neck, fever, increased leukocytes in CSF…Spinal polio: destroys motor neurons… withered leg, equinus foot Bulbar polio: attacks respiratory centers in medulla/cranial nerves

8

coronaviruses - signs and symptoms

dry cough, dyspnea

8

heptatius C - incubation period

about 60 days onset

9

polio - vaccines

Killed (Salk) Vaccine: formaldehyde-fixed vaccine of 3 serotypes, not originally given much in US but now preferred since low risk, IM injection
Live Attenuated (Sabin) Vaccine: viral mutants that grow in gut but do not invade CNS, oral, causes gut proliferation/viremia

9

hepadnavirus - types

hepatits B

9

hepatitus C - signs and symptoms

anorexia, nausea, fever, jaundice, prodromal rash/arthritis

10

polio - class, subclass, enveloped, nucleic acid/structure

picornavirus; enterovirus; non-enveloped; +ssRNA, one segment

10

hepadnavirus - enveloped, nucleic acid structure, virion structure

enveloped; circular DNA, ds for most of length (2 gapped single stranded regions), one segment; icosahedral

10

hepatitus C - lab diagnostics

serological and PCR tests