VIVA Flashcards
(93 cards)
what are the healing stages (tissue)?
inflammation, proliferation, remodelling
what happens in the inflammation stage of tissue healing (vascular)?
hyperaemia
vasodilation
exudation
leukocytes
what happens in the inflammation stage of tissue healing (cellular)?
phagocytosis
lymphocytes orchestrate immune response
fibroblasts build tissue
what is hyperaemia
increased blood flow to the area
what is vasodilation?
widening of blood vessels
what is exudation?
leaking of proteins and fluids from capillaries to tissues
what chemicals are released in inflammation?
prostoglandins, histamine, bradykinins
what is phagocytosis?
phagocytes (neutrophils, monocytes, macrophages) engulf foreign bodies to prevent infection
what happens in the proliferation stage of tissue healing?
fibroplasia
angiogenesis
myofibroblasts
what is fibroplasia?
formation of fibrous tissue (granulation tissue)
what do fibroblasts secrete?
collagen III, PGs and fibronectins
what is angiogenesis?
creation of blood vessels
what promotes angiogenesis?
hypoxia and chemical messengers from inflammation phase
what are myofibroblasts?
derived from fibroblasts, make wound smaller
what happens in the remodelling phase of tissue healing?
collagen III -> collagen I
reduced cellular and vascular content, increased fibrous content
orientation of fibres along lines of stress
what do the tissue healing stages mean for rehab?
inflammation - rest, ice, protect
proliferation - ROM, isometric
remodelling - strengthen
how long do the healing stages take in muscle repair?
inflammation - 0-4 days
proliferation - 4 days - 4 weeks
remodelling - 4-12 weeks
what happens in fracture healing?
inflammation and haematoma
soft callus
hard callus
bone remodelling
what happens in inflammation/haematoma phase of fracture healing?
haematoma - ruptured blood vessels
necrotic bone endds
influx of migrating cells
exudation, phagocytosis
osteoclasts resorb dead bone ends
fibroblasts proliferate
angiogenesis
what is the soft callus?
cartilaginous phase
fibroblasts become collagenblasts, chondroblasts, osteoblastsw
what is the hard callus?
calcium salts laid down to form immature bone
soft callus undergoes endochondral ossification to become woven bone
what happens in the remodelling phase of fracture healing?
consolidation - new haversian systems, growth of blood vessels, more osteoblasts.
woven bone -> mature bone
strengthened along lines of stress
what is the time scale for fracture healing?
inflammation and haematoma 0-10 days
soft callus 25 days - 2-3 weeks
hard callus 8-12 weeks
remodelling 1-2 years
why do tendons take longer to heal than bones?
heavier collagen make up
longer and more complex remodelling process
less tolerant of stretching, quicker, sharper forces and varied loads