W10 Skeletal System Flashcards

(57 cards)

1
Q

what are the 2 types of stem cells

A

mesenchymal
hematopoietic

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2
Q

what do mesenchymal cells differentiate to

A

Chondrocyte
Osteoblast

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3
Q

what do hematopoietic cells differentiate to

A

Osteoblast

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4
Q

what do Osteoblast diff into

A

osterocyte

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5
Q

what hormone increases the Ca2+ levels

A

PTH hormone

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6
Q

what cells secrete Ca2+ out of bones

A

osteoclast

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7
Q

where is Ca2+ stored

A

in the bones

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8
Q

what cells uptake Ca2+ into bones

A

osteoblast

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9
Q

where is calcitonin secrete from

A

by thyroid C-cells

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10
Q

what does calcitonin do

A

inhibits osteoclast activity

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11
Q

what’s the main role of the skeletal system

A

protect internal organs
produce blood ells
and releases fat from bone marrow
stores and releases Ca2+ and phosphates

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12
Q

what is the Axial Skeleton made of

A

Skull
Vertebrae of the spine
Thoracic cage (Ribs and sternum)

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13
Q

what is the Appendicular Skeleton made of

A

Upper and lower limbs
Pelvis
Pectoral girdle (shoulder)

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14
Q

what are connective tissue main components

A

ECM:
- fibers
- ground substance
- inorganic matrix

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15
Q

what are the 2 types of connective tissue

A

loose and dense

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16
Q

what type of connective tissue are skeletal tissues

A

dense

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17
Q

what are the connective tissue fibres

A

collagen and elastin

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18
Q

what does elastin help to do

A

recoil after stretchw

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19
Q

what does collagen do

A

provides tensile strength

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20
Q

what are the connective tissue ground substances

A

proteoglycan
water and electrolytes

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21
Q

what do ground substances do

A

provide swelling pressure

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22
Q

what are the outer and inner layer of the cortical bone

A

periosteum
endosteum

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23
Q

what does inorganic matrix do

A

make tissues hard

24
Q

what are the 3 structures of the bone

A

cortical bone
spongy bone
bone marrow

25
what is endosteum adjacent to
medullar cavity
26
what maintains bone tissue
oestocyte
27
what is an oestergenic cell
a bone stem cell
28
what is Intra-membranous ossification
undifferentiated mesenchymal connective tissue
29
where does Intra-membranous ossification occur
skull clavicle
30
what is Endochondral ossification
bone formation
31
how does Endochondral ossification occur
via a cartilage intermediate
32
where does Endochondral ossification occur
all bones but skull and collarbone
33
what are the growth plate zones
reserve proliferative hypertrophic calcification ossification
34
what is hypertrophic zone
where bone cells get larger
35
what is the main point of endochondral ossification
bone growth in length
36
what is calcification
cell death
37
how does fracture healing work
direct healing or indirect healing
38
what is indirect healing of fracture like
endochondral ossification
39
what is calcitriol
vit D
40
where are parathyroid hormones released from
parathyroid gland
41
what does increase osteoblast activity do
reduce blood Ca2+
42
what does increase osteoclast activity do
increase blood Ca2+
43
what does thyroxine do
stimulate bone growth
44
what does calcitriol do
stimulates adsorption of Ca2+
45
what is wolff's law
bone adapts to the mechanical stresses
46
whats wolff's law used to drecribe
control of bone maintenance
47
what is Somatotropin
GH- growth factor
48
what is IGF-1
insulin like growth factor
49
when can length and thickness be added
when the growth plate of the bone is opened
50
what does vitamin d bind to
intracellular receptor VDR
51
what does the binding of VD3=VDR complex to DNA do
promotes calbindin and osteocalcin
52
what does PTH promote
osteoclast
53
which cells detect mechanotranduction in the bone
osteocyte
54
Why is it important t0 maintain calcium
Muscle twitching can be dangerous
55
How does IGF-1 bind to send signals
Bind to receptors for cell proliferation
56
What does thyroxine do
General metabolic effect
57
where is calcitonin produced
parafollicular cells