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HEMATOLOGY PPT (3rd year) > W3 > Flashcards

W3 Flashcards

1
Q

PROCESS THAT INCLUDES
CELL RENEWAL
CELL PROLIFERATION, DIFFERENTIATION, MATURATION

A

HEMATOPOIESIS

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2
Q

STEM CELL THEORY

ALL BLOOD CELLS ARE DERIVED FROM A SINGLE PROGENITOR STEM CELL

MOST WIDELY ACCEPTED

A

MONOPHYLETIC THEORY

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3
Q

MONOPHYLETIC THEORY

STEM CELL CALLED

A

PLURIPOTENT HEMATOPOIETIC STEM CELL

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4
Q

STEM CELL THEORY

EACH BLOOD CELL LINEAGES DERIVED FROM ITS OWN UNIQUE STEM CELL

A

POLYPHYLETIC THEORY

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5
Q

PRENATAL HEMATOPOIESIS: - PERIOD

CHIEF SITE:

19 DAYS EMBRYOLOGIC DEVELOPMENT

A

MESOBLASTIC PERIOD
YOLK SAC

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6
Q

FOUND IN YOLK SAC OF MESODERMAL CELLS

A

PRIMITIVE ERYTHROBLAST

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7
Q

2ND WEEK OF FETAL LIFE FORMATION OF - IN YOLK SAC

A

BLOOD ISLANDS

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8
Q

9TH WEEK OF FETAL LIFE
DEVELOPMENT OF -

A

PRIMITIVE ERYTHROBLAST

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9
Q

EMRYONIC HEMOGLOBIN

2 ZETA
2 EPSILON

A

GOWER 1

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10
Q

EMRYONIC HEMOGLOBIN

2 ALPHA
2 EPSILON

A

GOWER 2

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11
Q

EMRYONIC HEMOGLOBIN

2 ZETA
2 GAMMA

A

PORTLAND

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12
Q

PRENATAL HEMATOPOIESIS: -PERIOD

BEGINS AT 4-5 GESTATIONAL WEEKS
STARTS ON 2ND MONTH

A

HEPATIC PERIOD

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13
Q

PRENATAL HEMATOPOIESIS: - PERIOD

CHIEF SITE:

3RD MONTH OF FETAL LIFE

A

LIVER
HEPATIC PERIOD

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14
Q

PRENATAL HEMATOPOIESIS: HEPATIC PERIOD

OTHER ORGANS

THYMUS

A

T CELL

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15
Q

PRENATAL HEMATOPOIESIS: HEPATIC PERIOD

OTHER ORGANS

KIDNEYS/SPLEEN

A

B CELL

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16
Q

ERYHTOPOIESIS IN THIS SITE UNTIL NORMAL GESTATION

A

SPLENIC

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17
Q

SPLEEN: BECOMES MINIMAL BY THE 5TH MONTH

A

MYELOPOIESIS

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18
Q

SPLEEN: LIFETIME

A

LYMPHOPOIESIS

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19
Q

FETAL HEMOGLOBIN

2 ALPHA
2 GAMMA

A

HB F

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20
Q

PRENATALL HEMATOPOIESIS: - PERIOD

HEMATOPOIESIS BEGINS TO DEVELOP IN BONE MARROW CAVITY

START 5MOS OF FETAL LIFE

A

MEDULLARY/MYELOID

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21
Q

MYELOID-TO-ERYTHROID RATIO

ADULT LEVEL

21 WEEKS OF GESTATION

A

3:1

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22
Q

BY THE END OF - MONTHS THE BM BECOMES THE PRIMARY SITE OF HEMATOPOIESIS

A

6 MOS

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23
Q

ADULT HEMOGLOBIN

2 ALPHA
2 BETA

A

HB A1

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24
Q

ADULT HEMOGLOBIN

2 ALPHA
2 DELTA

A

HB A2

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25
PRIMITIVE , UNDIFFERENTIATED CELL
HEMOCYTOBLAST/ STEM CELLS
26
TISSUE LOCATED WITHIN THE CAVITIES OF THE CORTICAL BONES
BONE MARROW
27
BONE MARROW CAVITIES CONSIST OF - RESEMBLING A HONEYCOMB
TRABECULAR BONE
28
2 TYPES OF BM: HEMATOPOIETICALLY ACTIVE MARROW
RED MARROW
29
2 TYPES OF BM: HEMATOPOIETICALLY INACTIVE MARROW PRIMARILY COMPOSED OF ADIPOCYTES
YELLOW MARROW
30
BONE MARROW REPRESENT -% TOTAL BODY WEIGHT
3.5-6% 1500G
31
SITE OF B CELL MATURATION
BONE MARROW
32
RATIO OF RED MARROW TO YELLOW MARROW
MARROW CELLULARITY
33
MARROW CELLLULARITY MARROW HAS 30-70% HSCS
NORMOCELLULAR
34
MARROW CELLLULARITY MARROW HAS >70% HSCS
HYPERCELLULAR/HYPERPLASTIC
35
MARROW CELLLULARITY MARROW HAS <30% HSCS
HYPOCELLULAR/HYPOPLASTIC
36
MARROW CELLLULARITY MARROW HAS FEW OR NO HSCS
APLASTIC
37
FIRST PRECURSON IN EACH CELL LINE
BLAST
38
BONE MARROW EXAMINATION: ASPIRATION ML
30-35ML ASPIRATE 1-3ML
39
BONE MARROW EXAMINATION: ASPIRATION COMMON SITE FOR APPREHENSIVE PATIENTS
ILIAC CREST
40
BONE MARROW EXAMINATION: ASPIRATION USUAL SITE PUNCTURE IN ADULTS 2ND AND 3RD RIBS
STERNUM
41
BONE MARROW EXAMINATION: ASPIRATION FOR CHILDREN UNDER 2 YEARS OF AGE
TIBIA
42
BIOPSY USES NEEDLE AND CORE SAMPLE
NEEDLE BIOPSY
43
BIOPSY USED TO REMOBE CIRCULAR SECTION
TREPHINE
44
BONE MARROW SMEAR ML OF SPECIMEN ADDITIVE
0.3-0.5ML, EDTA
45
MARROW SMEARS W/O ANTICOAGULANT - TYPE: MINUTE DROP OF SPX
WEDGE TYPE
46
MARROW SMEARS W/O ANTICOAGULANT - TYPE: SEVERAL MARROW PARTICLES
PARTICLE SMEAR
47
MARROW SMEARS W/O ANTICOAGULANT - TYPE: SQUASHING PARTICLE BETWEEN 2 SLIDES
CRUSHED PARTICLE SMEAR
48
MARROW SMEARS W/O ANTICOAGULANT - TYPE: IMPRINT OF SPX + ZENKER
TOUCH PREP
49
M:E RATIO 6:1 INCREASE
INFECTION
50
M:E RATIO 25:1 INCREASE
LEUKEMIA
51
M:E RATIO 20:1 INCREASE
MYELOID HYPERPLASIA
52
M:E RATIO 3:20 DECREASE
MYELOID HYPOPLASIA
53
M:E RATIO 1:20 DECREASE
ERYTHROID HYPERPLASIA
54
M:E RATIO 5:1 INCREASE
ERYTHOID HYPOPLASIA
55
BONE MARROW DIFFERENTIAL CELLS COUNTED: -
500-1000CELLS
56
MOST MATURE CELL OF PHAGOCYTIC SYSTEM LARGE 30 UM IRREGULARLY SHAPED WITH PSEUDOPODS
MACROPHAGES NORMAL
57
12-25UM BLUE BLACK GRANULES
MAST CELLS NORMAL
58
SYNTHESIZE NEW BONE MATRIX WATERBUG/ COMET APPEARANCE
OSTEOBLASTS NORMAL
59
INVOLVED IN BONE DEMINERALIZATION AND RESORPTION 100UM
OSTEOCLASTS NORMAL
60
MACROPHAGES IN LIVER CELLS
KUPFFER CELLS
61
RETICULOENDOTHELIAL ORGAN FUNCTION: LYMPHOPOIESIS AND PHAGOCYTOSIS
SPLEEN
62
SITE OF EXTRAMEDULLARY HEMATOPOIESIS STORES 30% OF PLATELETS (1/3 OF PLATELETS)
SPLEEN
63
SPLEEN PULP CONTAINS LYMPHOID TISSUE
WHITE PULP
64
SPLEEN: WHITE PULP COTAINS MAINLY T CELLS
PALS PERIARTERIOLAR LYMPHOID SHEATHS
65
SPLEEN: WHITE PULP CONTAINS NAIVE B CELLS
PRIMARY FOLLICLES
66
SPLEEN: WHITE PULP CONTAINS DENDRITIC CELLS
MARGINAL ZONE
67
SPLEEN PULP CONTAINS SPECIALIZED MACROPHAGES FOR REMOBAL OF SENESCENT RBCS
RED PULP
68
SPLEEN: RED PULP PROCESS OF DESTROYING SENESCENT RBCS
CULLING
69
SPLEEN: RED PULP PROCESS OF REMOVING RBC INCLUSION
PITTING
70
SPLEEN: RED PULP REMOBAL OF MATURE RBC, DEGRADATION OF CELL ORGANELLES
CULLING
71
ACTS AS A FILTER TO REMOVE FOREIGN BLOOD CONTAMINANTS FOR BODYS INFECTION DEFENSE
LYMPH NODES
72
IMMATURE LYMPHOCYTES MATURE IN THE -
LYMPH NODES
73
LAYERS OF LYMPH NODES CONTAINS MACROPHAGE, FOLLICULAR DENDRITIC CELLS NAIVE OR RESTING B CELL
PRIMARY FOLLICLE-CORTEX
74
LAYERS OF LYMPH NODES CONTAINS PROLIFERATING B CELLS AND PLASMA CELLLS
SECONDARY FOLLICLES-CORTEX
75
LAYERS OF LYMPH NODES CONTAINS MAINLY T CELLS
PARACORTEX
76
LAYERS OF LYMPH NODES CONTAINS T CELLS, B CELLS, PLASMA CELLS, MACROPHAGES
MEDULLA
77
RESPONSIBLE FOR NORMAL DEVELOPMENT OF LYMPHOCYTES NECK AREA
THYMUS GLAND
78
FOUND IN BIRDS ANALOGOUS TISSUE IN MAN FOR NORMAL ANTIBODY PRODUCTION
BURSA FABRICUS
79
MAJOR COMPARTMENT/ CELL TYPES PRESENT IN THE FIRST FEW HOURS AFTER FERTILIZATION MOST VERSATILE CAN DEVELOP IN ANY HUMAN CELL TYPE EMBRYO TO FETUS
TOTIPOTENTIAL STEM CELLS
80
MAJOR COMPARTMENT/ CELL TYPES PRESENT SEVERAL DAYS AFTER FERTILIZATION CANNOT DEVELOP INTO FETUS
PLURIPOTENTIAL STEM CELLS
81
MAJOR COMPARTMENT/ CELL TYPES FROM PLURIPOTENT STEM CELLS LIMITED TO SPECIFIC TYPES
MULTLIPOTENTIAL STEM CELLS
82
CAN DIFFERENTIATE INTO ANY CELL LINE
STEM CELLS
83
STEM CELLS MULTIPOTENTIAL STEM CELLS -> NON-LYMPHOCYTES
CFU-S
84
STEM CELLS SECONDARY MULTIPOTENTIAL STEM CELLS ->LYMPHOCYTES
CFU-L
85
CAN DIFFERENTIATE INTO ONLY ONE CELL LINE
PROGENITOR CELLS
86
3RD MARROW COMPARTMENT= BLAST FORM
PRECURSOR CELLS
87
STIMULATES ERYTHROID CFU CELLS AND PROERYTHROBLASTS
EPO
88
STIMULATES MEGAKARYOCYTE CFU CELLS
TPO
89
STIMULATES GRANULOCYTE-MACROPHAGE CFU CELLS
G-CDF
90
STIMULATES B AND T CELL FORMATION WITH G-CSG AND GM-CSF
INTERLEUKINS
91
GROWTH FACTOR FROM PERITUBULAR CELLS OF THE KIDNEYS
ERYTHROPOIETIN
92
GROWTH FACTOR FROM ACTIVATED T LYMPOHCYTES TARGET: EO, MONO
IL-3

HEMATOLOGY PPT (3rd year) (5 decks)

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