Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Med Lab Exam 3 > WBC Disorders > Flashcards

WBC Disorders Flashcards

1
Q

most common cause of luekopenia is __________.

most common reactive cause of leukocytosis _______.

A

neutropenia

neutrophilia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

lab investigation of WBC disorders

A

CBC w/ differential

  • detects luekopenia or leukocytosis
  • detects anemia if it is present
  • PLT counts vary
  • differential: predominant cell type affected
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

increased # and toxic neutrophils (toxic granulation, Dohle bodies, vacuoles) . . . response to ______________.

A

bacterial infection or inflammation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

increased # and reactive lymphocytes . . . response to _________.

A

viral stimuli

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

T/F You should suspect malignancy if blasts are present.

A

True - blasts are always abnormal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Neutrophilia is associated with:

A

acute bacterial infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Neutropenia is associated with:

A

overwhelming infections, viral infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Lymphocytosis is associated with:

A

viral infections

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Pseudo neutrophilia

A

physical or emotional stimuli cause redistribution of blood pools . . . marginating -> circulating
short term increase in WBC count but NO left shift

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

increase in WBC and left shift is present

A

Pathologic Neutrophilia

- neutrophils leave blood in response to tissue damage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

causes of pathologic neutrohilia

A

acute and chronic bacterial infections

tissue destruction, metabolic disorders, drugs, chronic inflammatory disorders, following hemorrhage or hemolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

features of pathologic neutrophilia

A

increase WBC
increased # neutrophils
presence of toxic neutrophils (toxic granules, Dohle bodies, vacuoles)
increased ESR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

causes of absolute neutropenia

A

defects in bone marrow production
overwhelming infection
immune destruction
hypersplenism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

causes of absolute eosinophila

A

control of parasites
allergic states
skin and pulmonary disorders, drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

causes of absolute basophilia

A

chronic allergies or immediate hypersensitivity

malignancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

causes of absolute monocytosis

A

chronic infections (tuberculosis)
chronic inflammatory disorders
recovery from acute bacterial infection

17
Q

causes of absolute lymphocytosis

A

response to VIRAL infection - presence of reactive lymphs

need to rule out malignancy

18
Q

Leukemia

A

proliferation of malignant cells in bone marrow, often involves blood
may infiltrate liver, spleen, lymph nodes, CNS or skin
initially SYSTEMIC

19
Q

Lymphoma

A

proliferation of malignant lymphoid tissue cells in solid tissues . . . lymph nodes, spleen, GI tract
initially LOCALIZED

20
Q

Etiology of Malignant WBC Disorders

A 
viral theory
radiation/chemical damage
genetic factors and mutated oncogenes
environmental
immune dysfunction
21
Q

Diagnosis for Malignant WBC Disorders

A

bone marrow exam or tissue biopsy

22
Q

Acute or Chronic Leukemia?

young age, sudden onset

A

ACUTE - sudden onset, young age

Chronic - insidious, adults

23
Q

Acute or Chronic Leukemia?

mature cells

A

CHRONIC - maturing or mature cells

Acute - immature/blast cells

24
Q

Acute or Chronic Leukemia?

High WBC count

A

CHRONIC

Acute - variable

25
Q

Acute or Chronic Leukemia?

Neutropenia

A

ACUTE

26
Q

Acute or Chronic Leukemia?

Mild to severe anemia

A

ACUTE

Chronic - mild anemia if it is even present

27
Q

Acute or Chronic Leukemia?

Normal to high platelets

A

CHRONIC

Acute - low platelets

28
Q

Acute Myeloid Leukemia

A

infants and adults

WBC count normal to 100K - meyoblasts

29
Q

Acute Lymphoid Leukemia

A

ages 2-10

WBC count normal to 100 K - lymphoblasts

30
Q

Chronic Meylocytic Leukemia

A

25-60 years old
WBC 50-300K granulocyte proliferation
oncogene mutation - Philadelphia Chromosome; BCR/ABL
Gleevec

31
Q

Acute Meylocytic Leukemia

A

over 50 years old
males 2x > females
WBC 20-200K small mature lymphocytes
5-10 year survival; control symptoms

32
Q

Hodgkin’s Lymphoma

A

associated with EBV
enlarged lymph nodes
staged to demonstrate diagnostic cell type and determine prognosis
ESR abnormally increased

33
Q

Non-Hodgkin’s Lymphoma

A

enlarged lymph nodes, GI tumors
commonly spread to marrow and blood
biopsies to determine B or T/NK cell lineage

34
Q

Multiple Myeloma

A

proliferation of a malignant clone of plasma cells in the bone marrow
plasma cells produce one immunoglobulin type (monoclonal spike, red cell rouleaux, increased ESR)

Med Lab Exam 3 (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions