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WBC Morphology Flashcards

(51 cards)

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1
Q

WBC

Normal Range

A
  • 6,000-16,000 / uL
  • Absolute vs %
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2
Q

Blood Smear WBC Count

A
  • Normal: 10-30 WBCs per x10 counting field
  • # (average) x 10 = WBCs /uL
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3
Q

Leukocytosis

A
  • Elevated WBC count
  • Sign of infection
  • Differential to better diagnose
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4
Q

Leukopenia

A

Decrease in WBC

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5
Q

WBC Differentials

A
  • Count 100 WBC
  • Group each type found
  • This gives the WBC percent
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6
Q

Absolute WBC

A

% on count x total WBC count
* turn % into decimal
* answer in /uL
* most important value

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7
Q

WBC Count Corrected for nRBC

A

(WBC Count x 100) / (100 + nRBC Count)
* do when more than 5 nRBC
* use this new WBC count for absolute value

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8
Q

Granulocytes

Which Cells

A
  • Neutrophils
  • Eosinophils
  • Basophils
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9
Q

Agranulocytes

Which Cells

A
  • Lymphocytes
  • Monocytes
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10
Q

WBC Maturation

A
  • Myeloblasts
  • Promyelocyte
  • Myelocyte
  • Metamyelocyte
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11
Q

Metamyelocyte

A
  • Stage where WBC diferentials branch off (N, B, E)
  • Can be found in circulation in severe infection / inflammation
  • Kidney-bean shapped
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12
Q

Neutrophils

A
  • Most circulating WBC
  • First line of defense
  • Phagocytosis
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13
Q

Neutrophil Normal Range

A

3,000 - 11,300 /uL

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14
Q

Segmented vs Banded Neutrophils

A
  • Segmented = most mature
  • Band = immature
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15
Q

Banded Normal Range

A

0 - 400 /uL
* left shift when >500 /uL

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16
Q

Segmented Neutrophils

A

Most abundant WBC in domestic species (except ruminants)
* when in doubt, assume segmented

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17
Q

Banded Neutrophils

A
  • Same width throughout entire nucleus
  • Only see with leukocytosis
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18
Q

Neutrophilia

A
  • High neutrophil count
  • Acute inflammation
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19
Q

Neutropenia

A
  • Low neutrophil count
  • Severe infection
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20
Q

Neutrophilia w/ Left Shift

A
  • Bone marrow releases bands to meet demands
  • Segs > Bands
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21
Q

Neutropenia w/ Degenerative Left Shift

Study These Flashcards
A
  • Bands > Segmented
  • Poor Prognosis
  • May see Metamyelocytes
22
Q
23
Q

SMILED

Study These Flashcards
A

When stressed, you should smile
* Segs and
* Monos
* Increased
* Lymphs and
* Eosins
* Decreased

24
Q

Lymphocytes

Study These Flashcards
A
  • Immune function
  • Second most common WBC
25
Lymphocyte vs Reticulocyte
Reticulocyte * more cytoplasm * denser, smaller nucleus
26
Lymphocyte Normal Range
1,000 - 4,800 /uL
27
Lymphocytosis
* Increased lymphocyte count * Vaccinations or Viral response * May see with young animals (immunity)
28
Lymphopenia
* Decreased lymphocyte count * Stress
29
Lymphocytes
30
Monocytes
* Largest WBC * Phagocytosis * Macrophages when in tissue
31
Monocyte Normal Range
200 - 1,300 /uL
32
Monocytosis
* Increased monocyte count * Chronic inflammation
33
Monocytes
34
Eosinophils
* Important in hypersensitivity reactions and parasite infections * Modulation of immune system * Phagocytosis
35
Eosinophils | Granual Shapes
* Pink coloration * Dogs: round shaped * Cats: rod shaped (fills cytoplasm) * Greyhounds don't stain
36
Eosinophil Normal Range
100 - 750 /uL
37
Eosinophilia
* Increased eosinophils * Allergies, Fleas, HW
38
Eosinopenia
* Low eosinophil count * Stress or Steroids
39
Eosinophils
40
Basophils
* Important in hypersensitivity reactions and parasite infections * Not commonly seen
41
Basophil Normal Range
0 - 30 /uL
42
Basophilia
* Increased basophil count * Parasites and Allergies
43
Basophils
44
Pelger-Huet Anomaly
* Nuclear hyposegmentation * Common in Aussies * Chromatin still condensed * Look like bands - nucleus looks mature, darker
45
Nuclear Hypersegmentation
* Nucleus with >5 segments * Caused by aging of neutrophil - stress or prolonged storage * Report only if seeing lots
46
Toxic Change Cause
* Inflammation * Infection (bacterial) * Drug toxicity
47
Toxic Change | Appearance
* Neutrophil with basophilic cytoplasm * Dohle bodies * "foaminess"
48
Dohle Bodies
Small clumps of gray-blue areas within cytoplasm (ribosomes)
49
Siderotic Granules
* RBC - may look like stain artifacts or Dohle Bodies * Use Prussian Blue stain to differentiate
50
Siderotic Granules Cause
IMHA
51
Siderotic Granules

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