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T7- DDX II > Weakness > Flashcards

Flashcards in Weakness Deck (20):
1

gradual onset with progression of weakness sx in a child.

2 tumors:

1. astrocytoma
2. glioma

2

Difference btw Duchenne and Becker's M disorders

Duchenne: defective gene- absence of dystrophin

Becker's: normal dystrophin

3

x: c/c of double vision, difficulty swallowing, weakness in the arms/ jaws with repeated use

Myasthenia Gravis

(female- NM transmission is blocked by autoantibodies that bind to AcH receptors)

4

CC:
- anhedonia: inability to feel pleasure
- difficulty sleeping
- sense of worthlessness

depression

5

CC:
• incapacitating, decr ability to preform ADLs → not due to exertion only
• 6+ mo.

Chronic Fatigue sx

6

x: child has difficulty rising from bent over position

duchenne muscular dystrophy

7

X: pt's weakness gets worst when exposed to:
carbs
alcohol
cold
stress
rest after exercise

hypokalemia

(affects the Cl channels)

8

x: defect of Na+ channel gene on chrom. 17

hyperkalemia

worst by: exercising for more than an hour

better by: glucose, insulin, Ca+ gluconate

9

Which channels are defected in hyper/ vs hypokalemia

hyper: Na+ channel

hypo: Cl- channel

10

dz's that cause intention tremors and resting tremors

intention: MS

Resting: PD

11

x: numbness, tingling or weakness that resolves in a few days

has a genetic link of HLA-DR2

Labs:
- incr lymphocytosis
- incr protein in CSF
- IgG's
- oligoclonal bands in CSF

Multiple Sclerosis

12

X: brief jerking motion in sleep

myoclonus

13

causes of myoclonus (6)

1. uremia
2. alzheimers
3. epilepsy
4. creutzfeldt jakob dz
5. hypoxia
6. head trauma

14

4 causes of chores (involuntary movemetns of distal ext. and face)

1. huntington's
2. sydenham's sequella (rheumatic Q)
3. SLE
4. Drug induced

15

x: decr GABA, choreoform movements

Huntington's dz

16

x: writhing movements of the prox limb

due to dopamergic overactivity in the basal gg

athetosis

17

x: violent movement disorder, arm or leg is flung about conti.

Cause:
• infarct or tumor irritating the contralateral subthalamic nucleus

hemiballismus

18

x: bilateral leg weakness following a viral infection

Guillain- Barre sx

PE:
- motor signs
- absent DTR
- flucatuating in BP
- Diaphoresis

19

x: repeated head trauma in football player

combo of UMNL and LMNL
- atrophy, fasciculations and brisk DTRS (norm: sensory)

Amyotrophic lateral sclerosis (ALS)

20

x: lesion involving the schwann cells and N fibroblasts
- cafe- au- lait lesions

Neuroflibromatosis

type 1: hyperpigmentation nodules
type 2: prob with hearing and seeing