Week 123 Depression

Question 0

How do anti-cholinergics work?

Answer 0

They essentially bind to and block ACh receptors. ACh is the main naurotransmitter involved in muscle contraction.

Question 1

How do tricyclic anti depressants work?

Answer 1

Inhibit uptake of monoamines in the pre-synaptic neuron, by competitively binding to the ATPase monoamine pump in the cell membrane.

Question 2

Fluoxetine, paroxetine, sertaline and citalopram are all _______.

Answer 2

SSRIs

Question 3

SSRIs reduce the neuronal reuptake of ______

Answer 3

serotonin

Question 4

SSRIs are less dangerous and have less side effects than ____

Answer 4

TCSa

Question 5

The action of most anti-psychotic drugs is through ____________.

Answer 5

blockade of dopamine receptors

Question 6

D1 AND D2 ANTIPYSCHOTICS MAINLY BLOCK _________.

Answer 6

D2 RECEPTORS

Question 7

THE BLOCKADE OF ______ AND _____ REGIONS IS THOUGHT TO BE RESPONSIBLE FOR ANTI PYSCHOTIC EFFECTS.

Answer 7

MESOLIMBIC AND MESOCORTICAL REGIONS

Question 8

NEUROLEPTIC MALIGNANT SYNDROME IS A SIDE EFFECT OF WHICH DRUG TYPE?

Answer 8

ANTI - PSYCHOTICS.

Question 9

AMITRYPTYLINE AND IMIPRAMINE, NORTRIPTYLINE AND LOFEPRAMINE ARE ________. THEY ARE VERY DANGEROUS IN OVERDOSE DUE TO _______. THEY ARE CONTRA INDICATED _____

Answer 9

TCAS.
VENTRICULAR ARRYTHMIAS
IMMEDIATELY POST-MI

Question 10

CITALOPRAM, FLUOXETINE, PAROXETINE AND SERTRALINE ARE ALL ______. CONTR INDICATED IN UNDER _____. IT IS THE SAFEST CLASS OF ANTIDEPRESSANT IN ______.

Answer 10

SSSIS
18
OVERDOSE

Question 11

PHENELZINE AND MOCLOBEMIDE ARE EXAMPLES OF ______. WHEN TAKING YOU SHOULD AVOID TYRAMINE RICH FOOD.

Answer 11

MONOAMINE OXIDASE INHIBITORS.

Question 12

MIRTAZAPINE AND TRAZODONE ARE EXAMPLES OF _______.

Answer 12

RECEPTOR BLOCKERS

Question 13

VENLAFAXINE AND DULOXETINE ARE _______. CAUTION IS ADVISED WITH ALCOHOL, WARFARIN AND CLOZAPINE.

Answer 13

SEROTONIN AND NORADRENALINE REUPTAKE INHIBITORS.

Question 14

METCLOPRAMIDE, PROCHLORPERAZINE, CYCLIZINE, ORDANSETRON ARE ALL EXAMPLES OF DRUGS THAT ACT ON ______

Answer 14

THE GI SYSTEM

Question 15

BISOPROLOL, DOXAZOSIN AND ADRENALINE ALL ACT ON THE ______

Answer 15

CARDIOVASCULAR SYSTEM

Question 16

ATROPINE, IPRATROPIUM, OXBUTYNIN, CHLORPHENAMINE AND SALBUTAMOL ALL ACT ON _______.

Answer 16

THE RESPIRATORY SYSTEM

Question 17

HALOPERIDOL, QUETIAPINE, CO-BENELDOPA, ROPINIROLE, CODEINE, MORPHINE, TRAMADOL, LORAZEPAM, TAMULOSIN, FLUOXETINE, SUMATRIPTAN ARE ALL DRUGS THAT ACT ON THE _____

Answer 17

CNS.

Question 18

ACETYCHOLINE IS PRODUCED IN THE ____ AND _____

Answer 18

BASAL FOREBRAIN AND BRAINSTEM

Question 19

AMANDAMIDE IS PRODUCED ______ AND IS AN ENDO_____

Answer 19

EVERYWHERE

ENDOCANNABINOID

Question 20

DOPAMINE IS PRODUCED IN THE _____

Answer 20

SUBSTANTIA NIGRA

Question 21

ENDORPHINS ARE PRODUCED IN THE _____

Answer 21

HYPOTHALAMUS

Question 22

GABA IS PRODUCED IN THE ____ AND IS AN

Answer 22

HYPOTHALAMUS

Question 23

GLUTAMATE IS PRODUCED ____

Answer 23

EVERYWHERE

Question 24

GLYCIN IS PRODUCED IN THE ____, ____ AND ____

Answer 24

SPINAL CORD BRAIN STEM RETINA

Question 25

HISTAMINE IS AN ______ AND IS PRODUCED IN THE ______

Answer 25

IMIDAZOLEAMINE | POSTERIOR HYPOTHALAMUS

Question 26

NORADRENALINE IS AN ______ AND IS PRODUCED IN THE ______

Answer 26

CATECHOLAMINE | LOCUS CERULEUS

Question 27

SEROTONIN IS AN ______ AND IS PRODUCED IN THE _______.

Answer 27

INDOLEAMINE | RAPHE NUCLEI

Question 28

TO WHAT DOES THE TERM GLIA REFER?

Answer 28

THE OTHER CELLS IN THE NERVOUS SYSTEM 1: ASTROCYTES 2: OLIGODENDROCYTES 3: MICROALGIA 4: EPENDYMAL CELLS (MAKE CSF)

Question 29

GABA IS FORMED BY ALPHA DECARBOXYLATION OF _____

Answer 29

GLUTAMATE

Question 30

WHAT IS GLYCINE?

Answer 30

ANOTHER MAJOR INHIBITORY NEUROTRANSMITTER : ONLY IONOTROPIC RECEPTORS : ALSO CONDUCTS CL- BLOCKED BY STRYCHNINE

Question 31

WHAT TWO DRUGS TARGET SEROTONIN RECEPTORS?

Answer 31

1: LSD --> LYSERGIC ACID DIETHYLAMIDE 2: SUMATRIPTAN --> MIGRAINE TREATMENT

Question 32

WHICH TWO DRUGS BLOCK SEROTONIN RECEPTORS?

Answer 32

1: ONDANSETRON (ANTI EMETIC) 2: CLOZAPINE (ATYPICAL ANTIPYSCHOTIC)

Question 33

WHAT ARE THE CLINICAL OUTCOMES OF PROLONGED ACTIVATION OF GLUTAMATE RECEPTORS?

Answer 33

PROLONGED ACTIVATION = HYPEREXCITABILITY - SEIZURES - EXCITOTOXICITY - STROKE

Question 34

ALTERATION OF GABAERGIC RECEPTOR CIRCUITS HAS BEEN IMPLICATED IN ________.

Answer 34

``` HUNTINGDONS PARKINSONS SENILE DEMENTIA ALZHEIMERS SCHIZOPHRENIA ```

Question 35

WHAT ARE THE TWO TYPES OF GABA RECEPTOR?

Answer 35

GABA A - IONOTROPIC CONDUCT CL- WITH FAST INHIBITION GABA B - METABOTROPIC - PRESYNAPTIC INHIBITION OF GABA RELEASE (FEEDBACK CONTROL MECHANISM)

Question 36

WHERE DOES SEROTONIN ACT?

Answer 36

RAPHE NUCLEI PROJECTIONS THROUGHOUT CORTEX THALAMUS, HIPPOCAMPUS, MEDULLA, SPINAL CORD

Question 37

WHAT IS THE SERITONERGIC SYSTEM IMPLICATED IN?

Answer 37

``` DEPRESSION APPETITE CONTROL NAUSEA SLEEP SECUAL AROUSAL ANALGESIA ```

Question 38

WHAT DRUGS TARGET THE SEROTINERGIC SYSTEM?

Answer 38

SSRIs SNRIs ORDANSETRON

Question 39

WHICH 3 IONOTROPHIC RECEPTORS DOES GLUTAMATE PRIMARILY BIND TO?

Answer 39

AMPA NMDA KAINATE

Question 40

WHAT IS THE MAIN EXCITATORY NEUROTRANSMITTER IN THE CNS?

Answer 40

GLUTAMATE

Question 41

EXCITATORY AND INHIBITORY RECEPTORS ARE RECEPTORS OF WHICH TYPE?

Answer 41

IONITROPHIC