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Medicine Year 1 > Week 123 Depression > Flashcards

Week 123 Depression Flashcards

0
Q

How do anti-cholinergics work?

A

They essentially bind to and block ACh receptors. ACh is the main naurotransmitter involved in muscle contraction.

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1
Q

How do tricyclic anti depressants work?

A

Inhibit uptake of monoamines in the pre-synaptic neuron, by competitively binding to the ATPase monoamine pump in the cell membrane.

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2
Q

Fluoxetine, paroxetine, sertaline and citalopram are all _______.

A

SSRIs

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3
Q

SSRIs reduce the neuronal reuptake of ______

A

serotonin

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4
Q

SSRIs are less dangerous and have less side effects than ____

A

TCSa

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5
Q

The action of most anti-psychotic drugs is through ____________.

A

blockade of dopamine receptors

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6
Q

D1 AND D2 ANTIPYSCHOTICS MAINLY BLOCK _________.

A

D2 RECEPTORS

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7
Q

THE BLOCKADE OF ______ AND _____ REGIONS IS THOUGHT TO BE RESPONSIBLE FOR ANTI PYSCHOTIC EFFECTS.

A

MESOLIMBIC AND MESOCORTICAL REGIONS

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8
Q

NEUROLEPTIC MALIGNANT SYNDROME IS A SIDE EFFECT OF WHICH DRUG TYPE?

A

ANTI - PSYCHOTICS.

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9
Q

AMITRYPTYLINE AND IMIPRAMINE, NORTRIPTYLINE AND LOFEPRAMINE ARE ________. THEY ARE VERY DANGEROUS IN OVERDOSE DUE TO _______. THEY ARE CONTRA INDICATED _____

A

TCAS.
VENTRICULAR ARRYTHMIAS
IMMEDIATELY POST-MI

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10
Q

CITALOPRAM, FLUOXETINE, PAROXETINE AND SERTRALINE ARE ALL ______. CONTR INDICATED IN UNDER _____. IT IS THE SAFEST CLASS OF ANTIDEPRESSANT IN ______.

A

SSSIS
18
OVERDOSE

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11
Q

PHENELZINE AND MOCLOBEMIDE ARE EXAMPLES OF ______. WHEN TAKING YOU SHOULD AVOID TYRAMINE RICH FOOD.

A

MONOAMINE OXIDASE INHIBITORS.

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12
Q

MIRTAZAPINE AND TRAZODONE ARE EXAMPLES OF _______.

A

RECEPTOR BLOCKERS

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13
Q

VENLAFAXINE AND DULOXETINE ARE _______. CAUTION IS ADVISED WITH ALCOHOL, WARFARIN AND CLOZAPINE.

A

SEROTONIN AND NORADRENALINE REUPTAKE INHIBITORS.

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14
Q

METCLOPRAMIDE, PROCHLORPERAZINE, CYCLIZINE, ORDANSETRON ARE ALL EXAMPLES OF DRUGS THAT ACT ON ______

A

THE GI SYSTEM

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15
Q

BISOPROLOL, DOXAZOSIN AND ADRENALINE ALL ACT ON THE ______

A

CARDIOVASCULAR SYSTEM

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16
Q

ATROPINE, IPRATROPIUM, OXBUTYNIN, CHLORPHENAMINE AND SALBUTAMOL ALL ACT ON _______.

A

THE RESPIRATORY SYSTEM

17
Q

HALOPERIDOL, QUETIAPINE, CO-BENELDOPA, ROPINIROLE, CODEINE, MORPHINE, TRAMADOL, LORAZEPAM, TAMULOSIN, FLUOXETINE, SUMATRIPTAN ARE ALL DRUGS THAT ACT ON THE _____

A

CNS.

18
Q

ACETYCHOLINE IS PRODUCED IN THE ____ AND _____

A

BASAL FOREBRAIN AND BRAINSTEM

19
Q

AMANDAMIDE IS PRODUCED ______ AND IS AN ENDO_____

A

EVERYWHERE

ENDOCANNABINOID

20
Q

DOPAMINE IS PRODUCED IN THE _____

A

SUBSTANTIA NIGRA

21
Q

ENDORPHINS ARE PRODUCED IN THE _____

A

HYPOTHALAMUS

22
Q

GABA IS PRODUCED IN THE ____ AND IS AN

A

HYPOTHALAMUS

23
Q

GLUTAMATE IS PRODUCED ____

A

EVERYWHERE

24
Q

GLYCIN IS PRODUCED IN THE ____, ____ AND ____

A

SPINAL CORD
BRAIN STEM
RETINA

25
Q

HISTAMINE IS AN ______ AND IS PRODUCED IN THE ______

A

IMIDAZOLEAMINE

POSTERIOR HYPOTHALAMUS

26
Q

NORADRENALINE IS AN ______ AND IS PRODUCED IN THE ______

A

CATECHOLAMINE

LOCUS CERULEUS

27
Q

SEROTONIN IS AN ______ AND IS PRODUCED IN THE _______.

A

INDOLEAMINE

RAPHE NUCLEI

28
Q

TO WHAT DOES THE TERM GLIA REFER?

A

THE OTHER CELLS IN THE NERVOUS SYSTEM

1: ASTROCYTES
2: OLIGODENDROCYTES
3: MICROALGIA
4: EPENDYMAL CELLS (MAKE CSF)

29
Q

GABA IS FORMED BY ALPHA DECARBOXYLATION OF _____

A

GLUTAMATE

30
Q

WHAT IS GLYCINE?

A

ANOTHER MAJOR INHIBITORY NEUROTRANSMITTER
: ONLY IONOTROPIC RECEPTORS
: ALSO CONDUCTS CL-
BLOCKED BY STRYCHNINE

31
Q

WHAT TWO DRUGS TARGET SEROTONIN RECEPTORS?

A

1: LSD –> LYSERGIC ACID DIETHYLAMIDE
2: SUMATRIPTAN –> MIGRAINE TREATMENT

32
Q

WHICH TWO DRUGS BLOCK SEROTONIN RECEPTORS?

A

1: ONDANSETRON (ANTI EMETIC)
2: CLOZAPINE (ATYPICAL ANTIPYSCHOTIC)

33
Q

WHAT ARE THE CLINICAL OUTCOMES OF PROLONGED ACTIVATION OF GLUTAMATE RECEPTORS?

A

PROLONGED ACTIVATION = HYPEREXCITABILITY

  • SEIZURES
  • EXCITOTOXICITY
  • STROKE
34
Q

ALTERATION OF GABAERGIC RECEPTOR CIRCUITS HAS BEEN IMPLICATED IN ________.

A 
HUNTINGDONS
PARKINSONS
SENILE DEMENTIA
ALZHEIMERS
SCHIZOPHRENIA
35
Q

WHAT ARE THE TWO TYPES OF GABA RECEPTOR?

A

GABA A - IONOTROPIC CONDUCT CL- WITH FAST INHIBITION

GABA B - METABOTROPIC
- PRESYNAPTIC INHIBITION OF GABA RELEASE (FEEDBACK CONTROL MECHANISM)

36
Q

WHERE DOES SEROTONIN ACT?

A

RAPHE NUCLEI PROJECTIONS
THROUGHOUT CORTEX
THALAMUS, HIPPOCAMPUS, MEDULLA, SPINAL CORD

37
Q

WHAT IS THE SERITONERGIC SYSTEM IMPLICATED IN?

A 
DEPRESSION
APPETITE CONTROL
NAUSEA
SLEEP
SECUAL AROUSAL
ANALGESIA
38
Q

WHAT DRUGS TARGET THE SEROTINERGIC SYSTEM?

A

SSRIs
SNRIs
ORDANSETRON

39
Q

WHICH 3 IONOTROPHIC RECEPTORS DOES GLUTAMATE PRIMARILY BIND TO?

A

AMPA
NMDA
KAINATE

40
Q

WHAT IS THE MAIN EXCITATORY NEUROTRANSMITTER IN THE CNS?

A

GLUTAMATE

41
Q

EXCITATORY AND INHIBITORY RECEPTORS ARE RECEPTORS OF WHICH TYPE?

A

IONITROPHIC

Medicine Year 1 (39 decks)

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