Flashcards in Week 2- Histology Deck (25)
Describe the development of renal corpuscle
-Primitive renal tubule (which is derived from ureteric bud) is a blind ended tube which envelops growing glomerulus producing renal corpuscle
What is the vascular pole of the renal corpuscle?
-Afferent and efferent arterioles which form the glomerulus
What is the urinary pole of the renal corpuscle?
What are the two layers of the bowmans capsule and what lies between them?
-Parietal and visceral
What forms the filtration barrier of the renal corpuscle?
-Visceral layer of bowmans capsule (podocytes with foot processes)
-Fenestrated Capillary endothelium
How are podocytes formed?
-Visceral layer of bowmans capsule wraps around capillary endothelium
What is the function of the podocytes?
-To form filtration slits which overlap the fenestrated capillary
What epithelia lines PCT?
-Simple cuboidal with brush border
what is the longest most convoluted section of the nephron?
What are the 4 parts of the loop of henle?
-thin descending limb
-thin ascending limb
-thick ascending limb
What epithelia lines thin limbs in loop of henle?
What epithelia lines thick ascending limb in loop of henle?
Where in the kidney is the DCT?
What is special about the DCT epithelia?
-Contain numerous mitochondria for active transport
What makes up the juxtaglomerulus apparatus?
-The macula densa of DCT
-Juxtaglomerular cells of afferent arteriole of parent glomerulus
-Extraglomerular mesangial cells (lacis cells)
What is the macula densa?
-An area of dense cells which touch the parent afferent arteriole
What is the histiological difference between CD and DCT tubules?
-CD lumen larger and more irregular
What is the renal pyramid?
-organisation and merging of collecting ducts to form progressively larger ducts which empty into renal papilla
Describe the muscular histology of the ureter
-A muscular tube which has two layers of smooth muscle with a third layer appearing in lower third
What epithelium lines the ureter?
Are the ureters capable of peristalsis?
What epithelium lines the bladder?
How many layers of muscle does the bladder have?
What makes up a renal corpuscle?