Week 228 - Fungal Disease Flashcards Preview

Medicine Year 2 (Bear) > Week 228 - Fungal Disease > Flashcards

Flashcards in Week 228 - Fungal Disease Deck (42):
1

Week 228

Which condition is this?

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This is athletes foot.

2

Week 228

 

What is this?

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Ringworm of the toenail

3

Week 228

 

What is this?

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Tinea cruris

4

Week 228

 

What is this?

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Tinea corporis

5

Week 228

 

What is this?

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Oral candida

6

Week 228

 

What is this?

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Oesophageal candida

7

Week 228

 

What is this?

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Mucus plug in right lung. FUNGUS BRO. FUNGUS.

8

Week 228

 

What is this?

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Madura foot

9

Week 228

 

What is this?

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Madura foot

10

Week 228

 

What is this?

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Madura foot

11

Week 228

This patient recently had a liver transplant. What can you see?

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This is aspergilliosis

12

Week 228

 

What is this?

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Bilateral "ground glass" infiltrates. Fungal.

13

Week 228

 

What is this?

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Aspergilliosis

14

Week 228

 

What is this?

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Aspergillioma

15

Week 228

 

A patient with asthma or cystuc fibrosis is more likely to develop which kind of fungal infection?

Allergic bronchopulmonary Aspergilliosis (ABPA)

16

Week 228

 

What type of fungal condition is more likely in patients with pre-existing cavitating lung diseases?

Mycetoma

17

Week 228

 

LArge doses of inhaled organic material will induce which condition?

Hypersensitivity pneumonitis. Antigens can be fungi, avian proteins, and other organic dusts.

18

Week 228

 

Which type of hypersensitivity reaction is caused by T lymphocytes driving macrophages to cause tissue damage?

Type 4

19

Week 228

Which things will lead you to suspecting hypersensitivity pneumonitis?

 

  • REstrictive defects
  • Serum antibodies
  • High lymphocyte count in bronchiolar lavage
  • Occupation/hobbies
  • pets
  • Fine crackles at end of expiration

20

Week 228

Asthma is due to Type ___ hypersensitivity. In ABPA Type ___ and Type ___ hypersensitivity reactions take place.

 

1

3

4

21

Week 228

 

How is Allergic bronchopulmonary aspergilliosis diagnosed?

  • Raised IGE and eosinophilia
  • Hyphae in sputum
  • Positive skin test to Aspergillius
  • Broncho-alveolar lavage
  • Bronchiectasis over time

22

Week 228

How do Azoles affect fungi?

 

These inhibit cell membrane formation. There are two classes, Imidazoles and Triazoles.

23

Week 228

 

What is clotrimazole used for?

This is an anti fungal medication. It is used topically in the treatment of candida (thrush) and Tinea infections (but not in hair/nail infections).

24

Week 228

 

What is Fluconazole and what is it used for?

  • Used topically or orally
  • Used against Cryptococcus, dermatophytes, candida
  • NOT EFFECTIVE IN ASPERGILLUS
  • Lipophilic - penetrates CSF

25

Week 228

 

What is Voriconazole and what is it used for?

  • This is given either ORAL or IV (it's a big boy!)
  • Standard for blood borne Aspergilius and candida
  • Penetrates CSF but metabplised before excretion as very lipophilic

26

Week 228

 

Which drug is the standard treatment for blood borne aspergilliosis and candida?

Voriconazole

27

Week 228

 

Which antifungal drug is used (IV and oral) for treatment of aspergillus, candida and cryptococcus, as well as topically for nail infections?

Itraconazole

28

Week 228

 

Which anti fungal drug Inhibits B-glucan synthase, and is onl effective against aspergillus and candida?

Caspofungin

29

Week 228

 

Which anti fungal drug is used IV or Inrathecally (clue), and is used as a broad spectrum against systemic Aspergillus, Candida, and cryptococcus. IT also has a bunch of side effects!

 

There is a version that has less side effects - what's this called?

Amphotericin

 

Amphotericin B has less side effects.

30

Week 228

 

Which anti-fungal drug is used topically for the treatment of oral thrush and nappy rash?

Nystatin

31

Week 228

 

What is Terbinafine used for?

This is topical or oral, used for tyhe treatment of fungal infections in the hair or the nails (dermatophytes). Useful against tinea.

32

Week 228

 

What is Flucytosine used for?

This is an anti fungal drug, used for systemic candida/cryptococcus, used in conjunction with amphotericin (to prevent resistance).

33

Week 228

 

What is the best treatment for vaginal thrush?

Either clotrimazole or FLuconazole (topically)

34

Week 228

 

What is the best treatment for a suspected systemic fungal infection in an immunocompromised patient?

Amphotericin

Caspofungin

35

Week 228

 

What is the best treatment for oral thrush (fungal)?

Nystatin (topical)

Could use oral Fluconazole, but has systemic effects.

36

Week 228

What could you use to treat a fingal nail infection?

Itraconazole (oral) or topical

Terbinafine (oral)

Amorolfine (topical)

 

37

Week 228

 

What could you use to treat cryptococcal meningitis?

Amphotericin and Flucytosine (both IV)

38

Week 228

 

What could you use to treat Pneumocystis pneumonia?

Co-Trimoxazole (this is an antibiotic)

39

Week 228

 

What could you use to treat tinea (fungal) infections?

Limited cutaneous: Clotrimazole

Widespread: Itraconazole of Terbinafine (both oral)

40

Week 228

What could you use to treat Pityriasis Versicans (Tinea versicolor)?

 

Miconazole (topically), or Kitoconazole (topically)

41

Week 228

 

What can you use to treat Seborrhoeic Dermatitis?

Miconazole or Ketoconazole (both topical)

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