Week 3 Flashcards

(71 cards)

1
Q

learning objs for Tbl 2

A

Interpret a Forest plot
Discuss the relationship between GERD and ulcers and the following risk factors: H.pylori infection, coffee consumption, age, gender, bmi, pepsinogen I/II ratio, smoking, and alcohol
Describe the benefits of a cross-over study design
Draw the mechanism of dumping syndrome
Evaluate therapeutic options including pasireotide in the treatment of dumping syndrome

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2
Q

Malrotation

A

midgut herniates at 4th week and returns approx 10th week

rotates around the axis of SMA 270 degrees counterclockwise

see birds beak

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3
Q

complete nonrotation of the gut

A

ligament of treitz on the right side of abdomen does not cross midline

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4
Q

for malrotation what do you do before and after surgery

A

resuscitate first decompress the stomach with NG tube or they would have a cardiac collapse because they don’t have enough intravascular volume

place a foley

after the main procedure (i guess during the surgery tho) you take out the appendix because future appendectomy would present in the LUQ and would be confusing…..

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5
Q

ion status of pyloric stenosis

A

hypokalemic, hypochloremic metabolic alkalosis from vom

give normal saline until they start making urine, THEN replace the potassium one they have the “extracellular space” for it

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6
Q

intussusception

A

inversion of the small bowel into the large (usually)

think of the water snake toys

colicky abdominal pain “bring up their legs for a couple minutes, cry, and then they are fine. repeat every couple minutes. Bilious emesis, previous URI (causes lymphoid aggregates in the terminal ileum to increase), currant jelly stool (mucosal ischemia - order is lymphatic obstruction, venous congestion, arterial congestion, ischemia and necrosis)

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7
Q

where does the pelvic diaphrgm insert

A

“hangs” from a thickened layer of fascia on the obturator internus

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8
Q

muscles that make up the pelvic diaphram

A

levator ani (anterior) (contains the muscle from back to front iliococcygeus, pubococcygeus, puborectalis)

coccygeus is further back than those (AKA ischiococcygeus)

(piriformis is posterior to the coccygeus

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9
Q

What muscle connects the back of the pubic bone with the coccyx?

A

pubococcygeus

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10
Q

what structures go out of the greater siatic foramen in back into the lesser siatic foramen

A

pudendal nerve, artery, vein

hey curve around the ischial spine

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11
Q

what does the obturator nerve innervate

A

the adductors of the legs

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12
Q

what goes from the coccyx to the ischial spine

A

coccygeus

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13
Q

the pelvic abdomen originates from this muscle

A

Tendinous arch of obturator internus

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14
Q

what go in between piriformis and coccygeus

A

sciatic nerve
inferior gluteal N,A,V
pudendal (but it comes back in through the greater sciatic foramen)

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15
Q

what muscle extends anteriorly from the pubic bone to the ischial spine

A

obturator internus

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16
Q

what muscle goes from the posterior portion of the tendinous arch of the obturator internus to the coccygeus

A

iliococcygeus

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17
Q

what forms the “puborectal sling”

A

puborectalis

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18
Q

what are peptides cotransported with in order to get into the enterocyte

A

H+

Pept1 cotransporter

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19
Q

during the cephalic and gastric phases, vagal stimulation causes release of pancreatic enzyme including this peptide that isn’t in first aid so its not in my other flashcards

A

Monitor peptide

this and CCK-RP cause release of CCK from I cells into the blood

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20
Q

what part of the brain is important in monitoring energy expenditure vs energy intake

A

hypothalamus

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21
Q

neuropeptide-y

A

increases ghrelin

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22
Q

agouti related peptide

A

increases ghrelin

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23
Q

GIP
stimulus
target
effect

A

gastric inhibitory peptide

glucose, fatty acids, amino acids in small intestine

targets beta cells of pancreas

stimulates insulin release, inhibits gastric emptying and acid secretion

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24
Q

kupffer cells

A

macrophages of the liver

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25
what cells secrete cytokines inducing collagen production by stellate cells, which causes portal hypertension and hepatic encephalopathy
kupffer cells
26
bacteria convert bile into
urobilinogen - goes to urine and is converted to urobilin (makes urine yellow)
27
what compound make poop brown
stercobilin made from urobilinogen
28
what makes a gall stone
unconjugated bilirubin most of the time
29
what makes primary bile acids from cholesterol
7alpha-hydroxylase reabsorbed bile acids (chenodoxycholic and cholic acid) inhibit this enzyme
30
primary bile acids how do they become more effective
chenodoxycholic and cholic acid become more effective when conjugated to glycine or taurine
31
cholestyramine
bile acid sequestrant sequesters bile acids, which drives more creation of bile acids from cholesterol decreases cholesterol levels
32
lithocholic acid
a secondary bile acid created by bacterial deconjugation that is cytotoxic can be sulfated leading to its excretion
33
how to make conjugated bilirubin condition in infants who cannot make it?
bilirubin is conjugated with glucuronic acid by the enzyme glucuronyltransferase the enzyme is slow to start up in babies, leading to jaundice Infants who have a developmental deficiency in UDP-glucuronyl transferase are unable to hepatically metabolize the antibiotic drug chloramphenicol (binds 23s of 50s and prevents peptidyl transferase) which requires glucuronidation. This leads to gray baby syndrome decreased activity in gilbert syndrome, absent in crigler-najjar
34
3 things that are symported with sodium in the enterocyte
glucose, bile salts, amino acids
35
where is most diatary iron absorbed what transporters
duodenum HT (heme transporter) DMT1 (transports ferrous Fe2 form)
36
SGLT1
sodium glucose transporter symports glucose with sodium
37
in chronic pancreatitis which is first to go: endocrine or exocrine function
first to go is exocrine
38
type I autoimmune pancreatitis what cells what do they do
lymphocytic sclerosing of pancreas with IgG4 producing plasma cells makes a hard mass that feels and looks like pancreatic cancer somewhat analogous to sarcoid - where diverse organ manifestations are linked by the same histopathological problem
39
what causes pancreatic pseudocysts why are they called pseudo
acute pancreatitis, trauma inflammatory fibrous cyst that *lacks an epithelial lining (pseudocyst)* account for 75% of cysts in the pancreas. Cyst fluid are high in amylase
40
IPMN
intraductual papillary mucinous neoplasm this tumor communicates with the pancreatic duct and lacks ovarian type stroma see dilated ducts on ERCP (Endoscopic retrograde cholangiopancreatography) get really long columnar cells on histo. nuclei get dark, large, and rounded can lead to pancreatic exocrine carcinoma
41
most common location of pancreatic carcinoma
head
42
how do you diagnose pancreatic carcinoma
endoscopic ultrasound fine needle aspiration EUS FNA
43
pancreatic neuroendocrine neoplasms differences from pancreatic carcinoma
body or tail of pancreas instead of head well circumscribed!! hyperinsulinemia
44
pancreatic neoplasm assc with MEN
pancreatic neuroendocrine neoplasm
45
what do you order if you want to see if someone has gall stones
ultrasound radiolucent on xray (most of them)
46
you see yellow stuff in a gall bladder and you don't want to look like an idiot in front of a pathologist that cares as much as nelson. what do you say
it's cholesterolosis benign foamy macrophages full of cholesterol
47
what structures are in the hepatoduodenal ligament
common bile duct hepatic artery portal vein
48
skeletal muscle of the pharynx and upper esophagus derived from the ___ supplied by what nerve
branchial arch mesoderm vagus
49
what nerves supply the hindgut
S234 | pelvic splanchnics
50
what gives rise to much of the diaphragm what nerve does it have in it
transverse septum phrenic nerve (c3,4,5)
51
what embryological structure forms the liver
ventral mesentery
52
two ligaments of the ventral mesentery
hepatogastric hepatoduodenal
53
what nodes does the proctodeum (lower third of the anal canal) drain into
superficial inguinal nodes
54
what nodes does the hind gut portion of the anal canal (upper third of the anal canal) dain into
inferior mesenteric nodes
55
what cleaves an alpha 1,1 bond
trehalase
56
fiber is converted to what by bacteria in the lumen of the gut
acetate two carbon short chain F.A.
57
what component of human breast milk can be converted to short chain FA in the gut of a healthy infant
oligosaccharides
58
main insoluble fibers
lignin cellulose hemicellulose they decrease GI Transport time.
59
main form of fiber in metamucil
Psyllium soluble, viscous fiber. Indigestible and hold a lot of water
60
what is a substrate for amylasy - alpha1,4 bonds or beta
alpha - like simple starch example of beta would be cellulose (plant cell walls)
61
lignins
branched polymers of phenolic subunits. found in stems and seeds of fruits
62
what is abundant in apples, strawberries, and apples lmao whats the backbone
pectins backbone: galacturonic acid
63
"wound repair" carbohydrate of trees
gum arabic
64
what found in oatmeal is completely fermented by gut bacteria to short chain FA
beta-glucans homopolymers of glucopyranose
65
bacteria breaks down stuff to provide fuel for colonocytes what is the stuff? what is the transporter
they break down fiber into short chain FA get uptaken by monocarboxylate transporter
66
SCFAs effect our immunity how
act as a ligand for GPR43 e.g. in the macrophage inflammatory cytokines go down, IL-10 goes up (antiinflammatory.
67
GPR43 in adipose
decreased fat storage as TAG, and decreases insulin sensitivity when activated (mice with over expressed GPR43 are leaner)
68
pyloric stenosis assc with what antibiotic
systemic use of erythromycin when the baby is born (not in the eye)
69
why would you not want to be on a macrolide fro 14 days according to pruneski (f)
because of induction of the migrating motor complex | diarrhea
70
what pumps hydrogen out of the parietal cell
a K+ H+ ATPase
71
antibodies for celiacs
tissue trans glutaminase (TTG)