Week 4 - Wed - Fri Flashcards

(57 cards)

1
Q

In which - UC or CD - do you get pseudopolyps

what are they

A

in UC

they are actually just left over segments of gut epithelial cells that are not ulcerated

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2
Q

crypt architectural distortion means what - acute or chronic IBD

A

chronic

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3
Q

antibody tests that can differentiate UC from CD

A

CD: ASCA positive

UC: pANCA positive

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4
Q

quiescent colitis

A

damaged crypt architecture without inflammation

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5
Q

patients with chronic watery diarrhea and a normal colonoscopic exam

A

microscopic colitits

if nothing on biopsy then irritable bowel syndrome

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6
Q

what are you thinking if you see intraepithelial lymphocytes

what other cells are you looking for

A

microscopic colitis - lymphocytic colitis type

also see increased plasma cells

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7
Q

what are you thinking if you see eosinophilic tissue right under the epithelium on colon biopsy

A

microscopic colitis - collagenous colitis type

it’s a collagen band

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8
Q

colonic cells with enlarged nuclei and with normal cytoplasm

A

radiation colitis

if there was less cytoplasm, higher chance of it being cancer

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9
Q

intestinal segments that are particularly susceptible to ischemic damage

A

splenic flexure (SMA and IMA watershed zone)

sigmoid colon and rectum (IMA, pudendal artery, and iliac arter watershed zone)

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10
Q

smudgy hyalinized appearance to LP and atrophic crypts

A

ischemic colitis

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11
Q

hematochezia in an older patient with tortuous dilation of vessels

what is it
where in the GI system

A

angiodysplasia

most often found in cecum, terminal ileum, and ascending colon

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12
Q

smooth muscle proliferation between the crypts

A

characteristic of a “solitary rectal ulcer”

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13
Q

the majority of foodborne illness outbreaks are caused by what

A

norovirus

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14
Q

gram positive rod that can produce biofilms and spores, and adheres to invasive medical devices

found in rice and can survive cooking

A

bacillus cereus

B. Cereus = Box Car appearance

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15
Q
gram pos
bacilus
non-fastiduous
flagellated, motile
non spore forming
oxidase -
A

Listeria Monocytogenes

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16
Q
gram neg
curved rod
faculative anaerobe
flagellated, motile
oxidase pos
A

Vibrio spp

inc vibrio cholera

also grows in alkaline media (she didn’t mention it, but its in FA)

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17
Q
gram pos
bacili
spore-forming
obligate anaerobe
non-motile
A

clostridium perfringens

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18
Q

which bacteria produces an enterotoxin that binds to receptors in endothelial cell junctions and generates pores in the host mucosa cells

A

clostridium (perfringens, botulinum, difficile)

it’s called alpha toxin (lecithinase)

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19
Q

bacteria she wanted us to remember assc with cafeterias and will not normally cause fever or vom

A

c. perfringens

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20
Q
gram -
bacili (spiral)
microaerophilic
motile
cold sensitive

in what aninals?

what agar?

what possible complication

A

campylobacter jejuni

poultry

karmali agar - charcoal based

guillain-barre

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21
Q

karmali agar

A

used to culture campylobacter jejuni

has vanco for the gram positives, cefoperazone, and cyclohexamide

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22
Q

guillan-barre linked to what bacteria

A

campylobacter jejuni

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23
Q

what bacteria can generate H2S and cause an iron sulfide precipitate

A

salmonella enterica

24
Q

salmonella found it what pets

A

turtles

i like turtles

25
what is more likely to cause bloody diarrhea - campylobacter, Staph a.
campyobacter
26
common food poisoning thing that causes projectile vom, low grade fever, diarrhea
noravirus
27
tests you can do to definitively diagnose noravirus
PCR assay on stool or vom samples
28
vibrio parahaemolyticus enterotoxin
TDH (thermostable direct hemolysin) and/or TRH forms pores in RBCs, gut epithelial cells foodborne
29
is cholera food borne?
no
30
leading cause of death with food borne illness
listeria
31
how to test for listeria
look for the bacteria in a normally sterile site like blood or CSF don't look in the stool because it can be there and not cause Sx
32
which bug can cause infection initiating in the GI tract but resulting in neurological symptoms including slurred speech and muscle weakness?
clostridium perfringens, gram pos, spore forming this was one of her example questions
33
diarrhea (often bloody) fever stomach cramps was passed through feces and not food
shigella spp.
34
most mild shigella spp
shegella sonnei
35
``` gram - bacillus faculative anaerobe nonmotile non sporeforming mainly lactose negative oxidase negative ```
shigella spp
36
what bacteria use actin in the cells to move around because they don't have flagella
shigella spp
37
shigella toxin
shiga toxin aka AB5 toxin binds to Gb3 receptors on the colonic epithelial cells. the A subunit is what enters the cell, inactivates the ribosome 60s by removing adenosine from rRNA get dysentery, enhanced cytokine release, hemolytic uremic syndrome
38
STEC VTEC EHEC what kind of toxin
shigalike
39
ETEC vs EHEC (STEC) which has bacterial penetration
EHEC has penetration
40
EHEC (STEC) genes with toxins
stxA, stxB they are italicized when genes stx1 and stx2 are the toxins themselves
41
what bacterial infections of the gut do you not generally treat with antibiotics
EHEC (STEC) because of bacterial lysis/aggravation leading to HUS`
42
examples of high inoculum organisms
v. cholerae, c. perfringens | as opposed to STEC which can be only 100 organisms
43
GI bacterial infecition that is gram variable
C. diff
44
pseudomembranous colitis
C. diff
45
Mech of nitazoxanide | used for what
interferes with pyruvate::ferredoxin oxidoreductase enzyme dependent electron transfer (not in mammals - we have NADH-producing pyruvate dehydrogenase), essential to anaerobic energy metabolism protein primarly luminal used for cryptosporidium
46
what antiparasite interferes with thyroid tests and causes loss of visual acuity
iodoquinol - a luminal amebicide
47
paromomycin class? tox?
aminoglycoside tox - ototox, nephrotox (it is a luminal antiparasitic and doesn't have an many SE as other animoglycosides)
48
Tx for cyclospora (food borne outbreak)
bactrim
49
anal pruritis and intestinal infection symptoms. a worm - name? Dx? Tx?
enterobius vermicularis (pinworm) Dx - scotch tape test Tx - bendazoles
50
barrel shaped appearance of eggs Sx
trichuris trichiura Sx - bloody diarrhea, anemia, finger clubbing the best indicator of severity
51
mech of pyrantel pamoate and levamisole
selectively opens a restricted subgroup of nematode acetylcholine receptor ion channels in nematode nerve and muscle. depolarization, entry of Ca, spastic contraction, worm can't move and is swept away.
52
tape worm in: pork fish dogs
pork - taenia solium - cysticercosis, neurocysticercosis - Tx is praziquantel, albendazole for neurocysticercosis fish - diphyllobothrium latum - vit b12 deficiency - macrocytic anemia - Tx is praziquantel dogs - echinococcus granulosus - hydatid cysts in liver, causing anaphylaxis if antigens released (surgeons preinject with ETOH to kill cysts before removal - Tx is albendazole
53
proglottids in stool
its a tape worm (not specific to which)
54
common treatment for flukes (and also tapeworms)
praziquantel flukes are Schistosoma (in snails, cause liver and spleen granulomas, can lead to squamous cell of the bladder) and clonorchis sinensis (biliary tract inflammation --> pigmented gall stones, assc with cholangiocarcinoma)
55
we put up an immune response to what life cycle stage of schistosoma
egg
56
swimmers itch is causes by what type of organisms
flukes
57
3 parasites you are most likely to find in the us
giardia crypto pinworm (enterobius vermicularis)