Week 3 Flashcards

(63 cards)

1
Q

Give the generalised structure of the liver

A

Composed of lobules with a central vein and interlobular portal triads containing hepatic vein, bilary duct, and hepatic artery.

Has four lobes; right, left, caudal and quadrate

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2
Q

Describe what vessels join to eventually form the common bile duct

A

Right and left hepatic ducts join to form the common hepatic duct. The cystic duct then joins to the common hepatic duct to give the common bile duct

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3
Q

What are the four parts of the pancreas? It is intraperitoneal or retroperitoneal?

A

Head, neck, body and tail

Retroperitoneal

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4
Q

What type of imaging is used to investigate occlusions within the biliary tree?

A

ERCP

Endoscopic retrograde cholangiopancreatography

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5
Q

What are the two functions of the pancreas?

A

Endocrine; insulin and glucagon secreted from islet cells

Exocrine; digestive enzymes like amylase from acinar cells

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6
Q

Where does pancreatic pain usually present?

A

Epigastric region

Umbilical region

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7
Q

Where does dudenal ulcer pain usually present?

A

Epigastric region

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8
Q

The jejunum has a deep red colour, it is thicker and heavier than the ileum and has less vasculature. True or false?

A

False;

deep red colour, it is thicker and heavier than the ileum and has MORE vasculature (to allow more absorption)

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9
Q

The ileum has low and sparse folds. True or false?

A

True

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10
Q

What is the name for the mucosal folds in the jejunum?

A

Plicae circularis

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11
Q

What is the vertebral level of the superior mesenteric artery

A

L1

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12
Q

Where does the jejunum and ileum venous blood drain into?

A

The jejunal and ileal veins, then into the superior mesenteric veins then hepatic portal vein

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13
Q

What are the lymph nodes around the coeliac trunk called?

A

Celiac nodes

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14
Q

How many units have to be consumed in a day to refer it as binge drinking?

A

8 units

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15
Q

What type of diet predisposes you to oral cancer?>

A

Low in vitamin A and C

Low iron leading to atrophy of mucosal membranes

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16
Q

What type of infections predispose you to oral cancer?

A

HPV (an sti)

Candida (yeast infection)

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17
Q

When looking at a patient with oral cancer, what signs may you see?

A
Granular surface texture
Red bumpy surface
White/ yellow patches (erythroleukoplasia)
Ulceration
Fractured mandible
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18
Q

Patient presents with dysphagia, hoarse voice, a droopy eye lid, double vision and an unexplained pain in the top of the neck. Diagnosis?

A

Oral cancer

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19
Q

What is periodontal disease?

A

Infections of structures around the teeth including the gums

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20
Q

Describe the 4 progressive stages of periodontal disease

A

Gingivitis; inflammation of gums

Gingivitis and mild periodontitis; destruction of supporting bone and ligaments causing pocketing

Gingivitis and moderate periodontitis; more destruction of bone and deepening of pockets

Gingivitis, severe periodontitis, recession; severe destruction of bone (teeth), ligament, leading to tooth mobility and teeth loss

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21
Q

What equipment can you use to stage periodontal disease?

A

Beasic periodontal examination

Aka. A stick with bands on it to see how far the gum has receeded or how deep the cavity. If can stick probe more than 3mm into gum then problems

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22
Q

What are the possible treatments for periodontal disease?

A
Increase oral hygiene
Stop smoking
Scaling and root planning
Surgery
Long term maintenance
Extraction
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23
Q

What can you use an endoscope to treat?

A

Variceal bleeding; by banding or sclerosant (a glue with fibrin)

Arterial bleeding; using clips

Angiodysplasia (lesion on colon); argon plasma coagulation or radio frequency ablation

Mucosal resections (banding then resection)

Removal of intraluminal objects (gallstones)

Insertion of nutritional tubes e.g PEG, PEJ, naso-jejunal tube

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24
Q

Give examples of conditions that an endoscope is used to diagnose for

A

Oesophagitis, gastritis, coeliac disease, crohns, ulcerative colitis, sclerosing cholangitis (Associated with UC), mallory-weiss tears, varices

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25
What does a failure to secrete bile salts cause?
Lipid malabsorption as bile salts emulsify fats and allow their digestion. This can result in steatorrhoea (fat in the faeces)
26
How is cholesterol absorbed into the enterocytes?
Bound to a niemann-pickk like 1 protein which then allows it to be envaginated and it is then dissociated with the protein once in the cell.
27
Name the layer os the digestive tract from lumen to outer
Mucosa Submucosa Muscularis externa Serosa
28
What is the function of paneth cells? Where are they found?
At the base of intenstinal crypts in the small intestine Defence cells producing alpha-defensins, and antimicrobrial peptides like lysozymes
29
What is the name of the lymphatic capillary that runs in the centre of villi?
Lacteal
30
What are peyers patches and where in the GI tract are they found
Lymphoid tissue which start the immune response The ileum
31
Describe the histology of the mucosa in the oesophagus
Non-keratinized stratified squamous epithelium
32
Describe the histology of the mucosa in the stomach
Simple columnar epithelium with tubular glands
33
Describe the histology of the mucosa in the small intestine
Simple columnar epithelium with villi, and tubular glands
34
Describe the histology of the mucosa in the large intestine
Simple columnar epithelium with tubular glands
35
What is the function of the enteric nervous system in the GI tract
To control muscle and peristalsis throughthe myenteric plexus and the meissners plexus within the submucosa
36
What are the possible causes of chronic gastritis?
Autoimmune Bacteria Chemicals
37
What autoimmune disorder causes chronic gastritis?
They destroy the parietal cells which can produce gastric enzymes and intrinsic factor that allows the absorption of vitamin B12. This can also lead to anaemia Atrophic gastritis
38
What bacteria commonly causes chronic gastritis? What are the complications of this?
H. Pylori Gastric and duodenal ulcers, intestinal metaplasia, dysplagia, carcinoma
39
What are the chemical causes of chronic gastritis?
NSAIDS (ibuprofen, dicloflenax, high dose aspirin) Alcohol Bile reflux
40
What are some of the possible complications of peptic ulcers
Perforation, penetration, haemorrhage, stenosis, intractable pain
41
What are the most common type of gastric tumours?
Adeno-carcinoma
42
What is lynch syndrome
Dominant autosomal condition with a high risk of colon cancer
43
What is menetrier disease
Premalignant disease of the stomach showing gastric folds, excessive mucous production and little or no acid production
44
What are the two commonest types of adeno-carcinoma in the GI tract.
Intestinal Diffuse (in stomach)
45
What is the physiological response to nauseA?
Pallor Sweating Salivation (to help neutralise acids before entering oesophahus) Relaxed sphincters Reverse peristalsis into stomach from duodenum and jejunum
46
Describe the physiological steps to cause of vomiting
Suspension of slow wave activity Retrograde contractions from ileum to stomach Suspension of breathing and glottis closed Relaxation of LOS, contraction of diaphragm/ abdominal muscles, causing compression of stomach Ejection of gastric contents
47
What is menieres disease?
Disorder of the the inner ear causing disorientation
48
What are some causes of vomiting (four categories)
Absorbing toxic materials (morphine, chemo) Mechanical stimuli (gastritis, pharynx, MI) Vestibular system (motion sickness e.g menieres disease) Stimuli in CNS (pain, repulsive sights, odours)
49
What is the function of serotonin (5-HT) in the vomiting pathway?
Gut will produce serotonin from enteromaffin cells that will act on receptors to cause vagal discharge to the CTZ (chemoreceptor trigger zone) and NTS (nucleus tractus solitarius). These trigger vomiting
50
What are some consequences of profuse vomiting
Dehydration Loss of electrolytes (loss of protons and chlorides) can result in metabolic alkalosis Hypokalaemia
51
What treatment would you give to someone vomiitng due to meniers disease?
This gives them motion sickness so a muscarinic acetylcholine receptor antagonist or histamine receptor antagonist required E.g hyosine, scopolamine E.g cyclizine, cinnarizine
52
What treatment would you give for someone with drug induced vomiting?
Dopamine receptor antagonists, that block receptors in the CTZ (chemoreceptor trigger zone) E.g domperidone (doenst cross BBB) Metoclopramide
53
Give examples of some drugs that induce vomiting
Chemotherapy; cisplatin, doxorubicin Dopamine used in parkinsons; levodopa Opiate analgesics; morphine
54
What are the parameters for the glasgow-blatchford score? What is it used to assess?
Risk for upper GI bleed. 0-1 ok, 2-5 medium, more than 6 is high risk Blood urea; 6.5-8, 8-10, 10-25, >25. Starting from 2-6 points Haemoglobin men; 12-12.9, 10-11.9, <10. Points- 1,3,6 Systolic BP; 100-109, 90-99, <90 Points- 1,2,3 Extrapoint for tachypulse, melaena, syncope, hepatic disease, cardiac failure
55
What is the treatment for peptic ulcers that are actively bleeding, have overlying clot, visible vessel
``` Dual therapy of; Injection of adrenaline (vasoconstriction) Heater probe coagulation Clipping vessel Haemospray (temporary in emergency) ```
56
If there is just a peptic ulcer present what is the treatment??
Acid suppression with omeprazole Interventional radiology Surgery
57
What is the pathology behind varisces
Cirrhosis of the liver so portal blood pressure rises, causing increased resistance for drainage, causing vasodilation of surrounding veins as blood tries to find alternative route to the heart.
58
Man presents with spider naevi, leukonitia, ascites, palmar erythema, jaundice, encephalopathy, liver flap and splenomegaly. He is a heavy drinker. What is diagnosis?
Liver cirrhosis
59
What is the treatment for a variceal bleed?
``` Resusitation Terlipressin (constrict blood supply) Variceal ligation Sengstaken-blakemore balloon (emergency inflation of ballon to stop bleeding out Transjugular intrasystemic shunt ```
60
What is dyspepsia
Epigastric pain or burning, with early satiety NOT heartburn
61
What are some common causes of dyspepsia
Organic causes like peptic ulcer disease Functional causes like visceral hypersenitivity, abnormal upper GI motor functions, phsychological factors
62
How can you diagnose for H. Pylor
Faecal antigen test Gastric biopsy by urease test Culture
63
How would you treat for h. Pylori?
Triple therapy of omeprazole, amoxycillin, clarithromycin for 1 week