Week 4 Flashcards

(44 cards)

1
Q

define elderly

A

“young old” 65-74
“middle old” 75-84
“old” old >85 y.o

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2
Q

effects of covid on the baby boomer population

A

has possibly hasten the death of the baby boomer populatoin. either directly through COVID-19 or other factors

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3
Q

physiologic changes that occur in aging

A

Fat: increase in fat goes form 15 to 30%

Skelatel muscle decreases

bone density decreases

intracellular water decrceases
extracellular water remains the same

in genral, FATTER, WEAKER, DRIER

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4
Q

physiologic changes that occur in aging

CV system

A

anatomical: decreased contraction and filling capacity

physiological:
changes in conduction, decreased efficiency, decreased catacholamines

conduction system:
decrease d/t fibrosis or ischemia
“irritable”

Arteirla
*increased stiffness
*atherosclerosis

Venular:;
*decreased valves
*thrombosis, PE

Dx R/T aging cv system
*HTN
*TIA/CVA

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5
Q

physiologic changes that occur in aging

central nervous system

A

decreased rate of conduction

decreased strength of transmission

threshold for arousal blurred

reduced adaptation to physiologic stressors

increased recovery time in autonomic system

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6
Q

physiologic changes that occur in aging

Respiratory system

A

normal at rest,compromised at stress (known as duspena on exertion)

anatomical:
*decreased elasticity,
*muscle weakness
*skelatal deformities

function
*decreased ventilation
*decreased PaO2

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7
Q

physiologic changes that occur in aging

genitourinRY KIDNEYS

A

anatomic:
*nephron degeneration

Physiologic
*decreased ability to concentrate urime
decresed renal blood flow
decreased acid base adaptation when sressed

kidneys and problems w. aging kidneys

inadequate fluid intake
fluid loss d/t vomiting or diarrhea

shock d/t hemorrhage
cardiac failure
sepsis
injudicious use of diuretics
sod phosphate enemas

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8
Q

Genitourinary-bladder changes

A

gyno changes in women
*estrogen deprivation
atrophy
decreased secretions
results in urinary incontinance, dyspareunia, s/s menopause

reproductive chanhges in man
*gradual decrease of testosterone
decreased libido and sexual function, decreased energy and increased bodyfat,osteoporosis, decreased muscle mass, and decreased body hair

associated: diabetes mellitus, CV disease, and metabolic syndrome
*BPH
*erectile dysfunction

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9
Q

physiologic changes that occur in aging

GI

A

geenral: dentition and nutrition

esophageal: decreased motility, hiatal hernia

stomach: decreased acid production, intrinsic factos and motility

colon: decreased motility

pancreatic: decreased secretions

liver: decreased size, blood flow and CYP450

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10
Q

physiologic changes that occur in aging

Musculoskelatal

A

sturcutre and function
*atrophy
*decreased O2

joints:
erosion
degenration
calcification/ossification

skelatal degeration
*OP
*kyphosis

*fracturs and falls

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11
Q

physiologic changes that occur in aging

skin and derm sensory

A

change in skin, nails and hair
*decreased elasticity
decreased turgor
increased pigmentation

decreased vision
decreased hearing
other

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12
Q

leading causes of death in elderly

A

heart disease

malgnant neoplasms

chromic lower respiratory diseases

cerebrovascular diseases

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13
Q

define geriatric

A

*diminished homeostatic reserve capacity of all organ systems called homeostasis

in absence of stressors, homestasis causes no symptoms and very few restrictions on routine activities

progressive risk of homeostatic failure w. increasing age
(DECREASE OF FUNCTIONAL RESERVE)

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14
Q

define geriatric syndromes

A

multifactorial health conditions that occur when the accumulated effects of impairments in multiple systems render an older perosn vulnerable to situational challenges

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15
Q

facotrs of geriatric syndromes

A
  1. multiple risk factors and organ systems involved
  2. dx strategies to identify underlying causes sometimes ineffective, burdensome, dangerous, and costly

3.tpx mgmt of clinical manifestations can be helpful even in the absense of a firm dx or clarification of the underlying cause

could have a multiple etiologic factors and multiple pathogenic pathways causing SS

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16
Q

Geriatric Syndromes AGS GRS

A

DEMENTIA
DELERIUM
URINARY INCONTINENCE
FALLS
PRESSURE ULCERS
POLYPHARMACY

and others

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17
Q

delerium vs dementia

A

onset:
delerium: sudden w. deifnite beginning point
dementia: slow and gradual

duration:
delerium: days-weeks
dementia: usually permanent

cause:
delerium:almost always another ocnditions (infection, drugs, dehydration
dementia:: usualy chronic brian disorder

course:
delerium:usually reversible
dementia: slow progressive

attentioin
delerium: greatly impaires
dementia: unimpaire duntil dementia is severe

LOC:
delerium: variabily impaired
dementia: unimpaired until severe

orientation time/place
delerium: varies
dementia: impaired

memory
delerium: varies
dementia: lost, especially for recent events

need for medical attention:
delerium: immediate
dementia: required but less urgent

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18
Q

define frailty

A

occurs more in >90 y.o (>32%)

excess vulnerability to stressors, w. reduced abilty to maintain or regain homestasis after destabilizing event

(cdue to cumaltive decline in many phsyiologic sytems.vdpeletes homeostatic reserves

19
Q

contributing factors of frailty

A

chornic malnutrition
sarcopenia
decreased metabolic rate and activity
decreased appetite

other effects of stressor events
*falls
delerium (BOTH OF THESE OFTEN TRIGGERED BY ADMIN OF DRUGS)
fluctuating disability
increased care needs
admission to hospital
admission to long term care

20
Q

five phenotypical model indicators of frailty and their associated measures

A

weightloss (>4-5 kg or recorded wieghtloss of >/5% /year

self reported exauhstion

low energy expenditure (<383 kcal/weel) or <270 kcal/week in women

slow galt speed (standardized cutoff times to walk 4-57m

weak grip strength

21
Q

medications and frailty

A

polypharmacy could have a potential effect on frai.ty, however it being adirect cause is unclear

22
Q

clinical geriatric approach

A

maintenance of independence and prevent disability

multiple comorbidites

atypical presentation

*NOTE any symptom in an elderyly pt should be considered a drug side effect until proven otherwise

23
Q

iatragenic cascade

A

drug thats can cause side effects, and they are put on more drugs to treat other SE.

that i swhy it is important to identify potential side effects of drugs and don tlet them go unrecognized

24
Q

tools for comprehensive geriatric assessment

A

TIMER: tool to impromve medications in the elderly via review

geenral approach:

a. cost and coverage
b. adherance
c. safety
d. attain tpx goals

25
other things to conside rin comprehensive geriatric assessment
history taking problems (communication, underreporting, etc. medicaiton organinzation (pillbox, reminders, etc) non adhearance (intentional and nonintentional) assessing and monitoring drug therapy
26
drug related problems in elderly
underuse over use innapropriate prescribing (Beers, STOPP, STOPPFrail): r/t age and disease state)
27
Geriatric 5 m's
MIND MOBILITY MEDICATIONS MULTICOMPLEXITY MATTERS MOST
28
determinging med appropriateness in elderly
at younger elderly ages: more drugs are appropriate because they have a longer time of benefit of the drugs as they get older, time of benefit decreases and goal of careis more palliative instead of preventative
29
Physiologic changes associated w. aging Absorption
somtach emptying time- *delayed retention of indigestibles solids decreased rate of absorption (can be effected by analgesics and hpynotics) *acid-labile drugs intestinal motility: *some have increased or decreased motility *more commonly decrease dmotility gastirc acid secretion *reduced, can cause hypochlorydria/achlorhydria gastirc bloodflow *may decrease absorption of high permeability drugs REDUCED FIRST PASSED EFFECT *reach systemic circulations at higher concentrations (ex: morphine, lidociane, propanolol, verapamil) ***however, overall, no significant effect on rate or extent of absorption
30
absoprtion from transdermal route
dryer skin fatter skin less perfused skin effects: same absorption of lipophilic compounds decreased absoprtion of hydrophyllic compounds cachexia: loss of muscle , can effect absorption of durgs ex: use of fentanyl patches * absoption is longer and degree of pain tolerance effects how long the fentanyl patch is effective in pts
31
absorption form a mucosal standpoint
sublingual buccal rectal stomal all remian inteact
32
Physiologic changes associated w. aging Distribution
decrease lean body mass increased fat: increase lipophyllic drug vd decreaed water: decreased vd of hydrophillic drugs (lthium, theophylline, AG, etoh)
33
metabolism in elderly
reduced 3a4 no change in 2d6 decrease in hydroxylation and decreased demethylation in phase 1 metabolism some evidence of decrease in >80yo of phase 2 metabolism glucornonidation decrease mass and volume of liver
34
drugs that won emetabolize well
benzos
35
changes in renal function due to
decrease volume, weight, renal bloodflor, and glomerular function and tubular functoin ALWAYS CALCULATE CrCl accumaltion of toxic metabolite accumulation
36
DURGS EFFECTED BY DECREASED RENAL FUNCTION
ACE beta blockers
37
change sin pharmacodynamics
info limited: some drugs can increase sensitivty, some can blunt response
38
drug classes innaprporpaite in oldr adultas
ACH confusion, other systemic adr BENZOS: falls, delerium AD-increased risk of falls, tca's, ach (paroxetine) NSAIDS- gi toxicity, cv risks( mi, hf), aki
39
ACH effects
common ach meds: antihistmaines TCAs PAROXETINE atropine oxybutnin tolteridine
40
process of deprescribing
1. ascertain info on all meds currently taking, and adherance for each and why 2. assess pt drug regimen for risk for drug induced harm 3. assess eligiabilty for d/c 4, prioritize d/c list stareting from highest harm and lowest benefit,
41
tisk factors to fals
age releated muscle weakness comorbidities
42
consequences of falls
fear o f falling loss of confidence, mobility and the ability to live independently
43
itnerventions in preventing falls
multimodal interventions cause better reduction of falls medication management home
44
goald of med mgt to prevent falls