Week 4 Flashcards
(124 cards)
What are the dual functions of the pancreas?
• Endocrine gland secreting hormones – insulin and
glucagon
• Exocrine gland producing digestive enzymes
Islets of Langerhans are cells of pancreas involved in _____ function
Islets of Langerhans are cells of pancreas involved in
endocrine function
What causes diabetes mellitus?
Defective endocrine function in pancreas
• Pancreas produces little or no insulin
• Pancreas makes insulin, but insulin doesn’t work as it should
What is diabetes mellitus?
Disease that prevents body from properly using energy from food
What is a simplified review of metabolism?
- Food broken down to glucose (simple sugar)
- Glucose provides energy our body needs
- Pancreas releases insulin which attaches to and signals cells to absorb glucose from bloodstream
- Without insulin, glucose can’t be utilized by cells for energy and glucose remains in the blood (hyperglycemia)
What is the normal fasting plasma glucose level?
< 100 mg/dL
What is the prediabetes fasting plasma glucose level?
100-125 mg/dL
What is the diabetes fasting plasma glucose level?
> 125 mg/DL
What is the normal two-hour oral glucose tolerance plasma glucose level?
< 140 mg/dL
What is the prediabetes two-hour oral glucose tolerance plasma glucose level?
140-199 mg/dL
What is the diabetes two-hour oral glucose tolerance plasma glucose level?
> 200 mg/DL
What are the characteristics of type 1 DM?
- Previously called insulin dependent DM
- Absolute deficiency of insulin production and secretion
- Require exogenous insulin
What are the characteristics of type 2 DM?
- Previously called non-insulin dependent DM
- Much more prevalent
- Caused by combination of cellular resistance to insulin action and an inadequate compensatory insulin secretory response
- Can be controlled with diet, exercise, and oral hypoglycemic agents
What are the features of type 1 DM?
- Age at onset: Usually < 20 y/o
- Proportion of all cases: < 10%
- Type of onset: Abrupt
- Etiologic factors: Possible viral/autoimmune, resulting in destruction of islet cells
- Body weight at onset: Normal or thin
What are the features of type 2 DM?
- Age at onset: Usually > 40 y/o; increasing number of cases in all ages, including kids
- Proportion of all cases: > 90%
- Type of onset: Gradual
- Etiologic factors: Obesity-associated insulin resistance
- Body weight at onset: Majority are obese (80%)
What are the characteristics of Latent Autoimmune Diabetes in Adults (LADA)?
- Slow progressing form of autoimmune diabetes
- Similar etiology to Type 1, but onset usually > 30 y/o
- Don’t need insulin for several months up to years after diagnosis
What are the characteristics of Maturity onset diabetes of the Young (MODY)?
- More likely to be inherited, stronger genetic risk factor
- Shares type 2 diabetes symptoms
- NOT linked to obesity
- Develops before age 25
What is pre-diabetes?
When body can’t utilize glucose correctly
• Body cells do not recognize all of the insulin
• Cells stop responding to action of insulin
What does pre-diabetes result in?
In rise of blood glucose (high but not high enough)
What are the characteristics of pre-diabetes?
May have trifecta of prediabetes, HTN, and dyslipidemia – increases risk of developing Type 2 DM and heart disease
What are the cardinal signs and symptoms of type 1 diabetes?
- Polyuria (excessive urination)
- Polydipsia (excessive thirst)
- Weight loss with polyphagia (excessive hunger)
- Blurred vision
What are the cardinal signs and symptoms of type 2 diabetes?
- May have polyuria and polydipsia
- Visual blurring
- Neuropathic complications
- Infections
- Significant blood lipid abnormalities
- Often asymptomatic
What are the non-modifiable risk factors for type 2 diabetes?
- History of gestational diabetes
- Race/ethnicity
- Age over 45 years
- Family history of diabetes
What are the modifiable risk factors for type 2 diabetes?
- Physical inactivity
- High body fat or body weight
- High blood pressure
- High cholesterol