Week 4 necrosis

Question 1

Coagulative necrosis

Answer 1

Seen in ischemia/infarction. Cell outlines seen but nuclei gone. Increased eosinophilia leads to pink/red color

Question 2

Liquefactive necrosis

Answer 2

Seen in bacterial abscesses and CNS ischemia. Neutrophils release lysosomal enzymes that digest tissue. Can see neutrophils and cell debris

Question 3

Caseous necrosis

Answer 3

Cheese like gross appearance. Debris surrounded by lymphocytes and macrophages (granulomas). Seen in TB, systemic fungi and Nocardia

Question 4

Fat necrosis

Answer 4

Seen in pancreatitis and breast tissue injury. Saponification of fat and calcium

Question 5

Fibrinoid necrosis

Answer 5

Vessel walls have eosinophilic layer of proteinaceous material. Seen in vasculitis

Question 6

Gangrenous necrosis

Answer 6

Seen in distal extremities and GI tract. Dry: ischemia, coagulative. Wet: superinfection, liquefactive on top of coagulative