Week 8

Question 1

Hodgkin vs non Hodgkin: localized, single group of nodes with contiguous spread. Better prognosis. Reed sternberg cells

Answer 1

Hodgkin

Question 2

Hodgkin vs non Hodgkin: multiple nodes involved, extranodal involvement. Most B cell, some T cell. No reed sternberg cells. Worse prognosis

Answer 2

Non Hodgkin

Question 3

List non Hodgkin B cell neoplasm types

Answer 3

Burkitt Lymphoma
Diffuse large B cell lymphoma
Follicular lymphoma
Mantle cell lymphoma
Marginal zone lymphoma
Primary central nervous system lymphoma

Question 4

List non Hodgkin T cell neoplasm types

Answer 4

Adult T cell Lymphoma
Cutaneous T cell lymphoma (subtype mycosis fungoides)

Question 5

List plasma cell dyscrasias

Answer 5

Multiple Myeloma
Waldenstrom macroglobulinemia
Monoclonal gammopathy of undetermined significance (MGUS)

Question 6

List plasma cell dyscrasias

Answer 6

Multiple Myeloma
Waldenstrom macroglobulinemia
Monoclonal gammopathy of undetermined significance (MGUS)

Question 7

List lymphoid neoplasm leukemias

Answer 7

Acute lymphoblastic leukemia/lymphoma (ALL)
Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL)
Hairy cell leukemia

Question 8

List myeloid neoplasm leukemias

Answer 8

Acute myelogenous leukemia
Chronic myelogenous leukemia

Question 9

List myeloproliferative neoplasms

Answer 9

Polycythemia Vera
Essential thrombocythemia
Myelofibrosis

Question 10

Reed sternberg cells (bilobed nucleus with 2 mirror image halves, owl eyes). RS cells are CD15+ and CD30+. B signs and symptoms. Bimodal age distribution.

Answer 10

Hodgkin lymphoma

Question 11

More common in kids. Starry sky appearance with tingible body macrophages. Associated with EBV. Jaw lesions in endemic form in Africa. Pelvis or abdomen in sporadic form. t(8;14) translocation of c-myc and heavy chain Ig

Answer 11

Burkitt lymphoma (burkid, starburst)

Question 12

Adults with cutaneous lesions; common in Japan, west Africa, and the Caribbean. Lytic bone lesions and hypercalcemia. Caused by HTLV, can be associated with IV drug use

Answer 12

Adult T cell lymphoma

Question 13

Heterogenous group of T cell neoplasms affecting the skin, with blood lymph node or viscera. Mycosis fungoides is most common subtype. Erythematous patches in sun protected areas of skin

Answer 13

Cutaneous T cell lymphoma

Question 14

Over production of IgG (most common) > IgA > Ig light chains. CRAB features (hyperCalcium, Renal insufficiency, Anemia, Bone lytic lesions. Light chains in urine (bence jones)

Answer 14

Multiple Myeloma

Question 15

Overproduction of IgM. Clinical ft: anemia, B symptoms, lymphadenopathy, hepatosplenomegaly, hyperviscosity (headache, dizziness, blurry vision, ataxia)

Answer 15

Waldenstrom macroglobulinemia (lymphoplasmocytic lymphoma)

Question 16

Overproduction of any type of Ig, but asymptomatic. 1-2% risk of becoming multiple myeloma each year

Answer 16

Monoclonal gammopathy of undetermined significance

Question 17

Common signs of AML

Answer 17

Auer rods and DIC

Question 18

What CDs are present in CLL

Answer 18

CD19/CD20 and aberrant CD5

Question 19

Which condition has CRAB features

Answer 19

Multiple Myeloma

Question 20

Which CD is present in multiple myeloma

Answer 20

CD138

Question 21

Which CD is present in hairy cell leukemia

Answer 21

CD103