Week 5 Flashcards
What are the indications for pulmonary pharmacological interventions?
• Reduce bronchospasm • Reduce inflammation/allergic reaction • Reduce mucous production • Treat bacterial infection • Improve Oxygenation • Special Considerations: - Cough suppressant - Smoking cessation
What role does the sympathetic nervous system play in pulmonary?
Causes bronchodilation by increase cAMP, resulting in:
• Facilitates smooth muscle relaxation
• Inhibition of Mast Cells (inflammatory response and mucous production)
What role does the parasympathetic nervous system play in pulmonary?
Causes bronchocontrstriction by increasing cGMP resulting in:
• Facilitates smooth muscle constriction
• Facilitation of Mast Cells (inflammatory response and mucous production)
What is the primary method of drug administration to the lungs?
Primarily through inhalation (aerosol)
• May also be delivered orally or IV
What are the benefits of a Metered Dose Inhaler (MDI) or Dry Powder Inhaler (DPI)?
- Rapid delivery and absorption of medication
- Large Surface area
- Delivered Directly to tissue
- Less systemic effects
What are the limitations of a Metered Dose Inhaler (MDI) or Dry Powder Inhaler (DPI)?
- Unable to predict exact dosage
- Delivery is dependent on inspiratory flow
- Can be irritating to tissues
How is an inhaler used properly?
• Shake for 2-5 seconds, remove cap, inspect inhaler
• If the inhaler hasn’t been used in a while, may need to prime it.
• Breathe out all the way.
• Start breathing in slowly through your mouth, then press down on the inhaler 1
time.
• Keep breathing in slowly, as deeply as you can.
• Hold breath and slowly count to 10.
• Wait about 1 minute before you take your next puff (Beta agonists only)
What is a spacer?
Also known as aerosol-holding
chambers, add-on devices and
spacing devices, long tubes that slow the delivery of medication from pressurized MDIs.
What are the characteristics of a spacer?
• Helps improve delivery of
medication.
• Often used for inhaled
corticosteroids and with younger patients
What is a nebulizer?
A device that mix drugs with air to form a fine mist that is inhaled through a mask
What are the characteristics of a nebulizer?
• Prolongs the delivery of the medication (10minutes)
• Originally thought to improve delivery of medication to distal bronchioles (Inconclusive)
• Useful for patients who cannot perform MDI technique correctly
- Young children
- Patients in acute distress
What are the general classifications of bronchodilators for pulmonary pharmacology?
- (SNS) Adernergic Agonists (Sympathomimmetics)
- (PNS) Cholinergic antagonists (Anti-cholinergic)
- Methylxanthines
What are the characteristics of bronchodilator: Epinephrine (Epi-Pen)?
- Non specific beta agonist
- Used most often in emergent cases (anaphylaxis and sepsis/resp failure)
- Can be delivered (IV, IM, SubCut or Inhalation)
- Short time to effect 3-15minutes
- Short peak effect time ~20minutes
- Will affect other tissues with beta and alpha receptors
What are the characteristics of Bronchodilator Adernergic Agonist: SABA-Short acting (rescue)?
- Albuterol (Ventolin) (most common)
- Time to effect 5-15min
- Duration: 3-6hrs
What are the characteristics of Bronchodilator Adernergic Agonist: LABA-Long acting (maintenance)?
Salmeterol (Serevent)
• Time to effect: 10-20minutes
• Duration: 12hrs
What are the side effects for Bronchodilator Adernergic Agonist?
- Tachycardia,
- Tremors
- Nervousness,
- Restlessness
- Weight Loss
What does Bronchodilators: Cholinergic antagonists do?
Block the muscarine receptors in the bronchioles (LAMA)
What are the characteristics of Bronchodilators: Cholinergic antagonists?
• Drug of choice for COPD • Not used as often for asthma • Not absorbed well into bloodvstream • Less side effects than Beta Agnonists • Most Common: - Ipratropium (Atrovent) 3 4/day - Tiotropium (Spiriva) 1/day
What medicine provides a mix between SABA and LAMA?
Combivent
• Ipratropium bromide and
albuterol sulfate.
What are the characteristics of Bronchodilators: Methylxanthines?
Aka Xanthine deriviatives
• Common examples:
- Theophylline, Theobromine and caffeine
• Inhibit phosodiesterase enzyme
(PDE).
- Increases cAMP
- May also act as an adenosine antagonist
• Most common delivery route is oral, may also be injected (IV)
What are the side effects of Bronchodilators: Methylxanthines?
- Tachycardia, HA, irritability, restlessness
* Theophylline Toxicity: can cause arrthymias and seizures
What is the mechanisms of action of anti-inflammatory: glucocorticoids?
- Control inflammatory mediated bronchospasm
- Inhibit production of pro-inflammatory products (cytokines, prostaglandins, leukotrienes etc)
- Decreases vascular permeability
- Immunosuppression: Inhibits migration of neutrophils and monocytes
- Increases the effect of Beta Agonsits
What are the characteristics of inhaled anti-inflammatory: glucocorticoids?
Used often for long term maintenance of Asthma
• Budenoside (Pulmicort), Beclemethasone (Belcovent), Fluticasone (Flovent)
What are the characteristics of oral anti-inflammatory: glucocorticoids?
Used often with acute infections, or exacerbations, 1-3weeks max
• Prednisone