week 6 Flashcards

Genes/ genetics, heart anatomy + heart physiology (44 cards)

1
Q

What does DNA stand for?

A

DeoxyriboNucleic Acid

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2
Q

Where is it found?

A

in the nucleus, tightly packed

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3
Q

What is it made of?

A

nucleotides

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4
Q

DNA purpose

A

it is instructions to build proteins

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5
Q

Components of DNA

A

nucleus -> chromosomes -> nucleosome strands -> chromatin -> double helix ->

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6
Q

Parts of a chromosome

A

centromere, short arm, long arm, telomere

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7
Q

Telomere

A

Protect

Often reduce after each replication

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8
Q

Number of chromosomes

A

46 chromosomes

23 – Mum
23 – Dad

make 23 pairs

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9
Q

DNA letters (4)

A

Adenine
Cytosine
Guanine
Thymine

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10
Q

Types of chromosomes

A

22 - autosomes

1 - sex chromosome

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11
Q

Genotype

A

gene which codes for a specific trait

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12
Q

Phenotype

A

physical expression (appeartance)

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13
Q

Alleles - trait names

A

variation on the same trait

  • if 2 identical ‐ called homozygous
  • if 2 different ‐ called heterozygous
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14
Q

Alleles - trait types

A

dominant:
- appears more frequently than another trait
recessive:
- expressed only when genotype is homozygous

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15
Q

Polygenic

A

> 1 gene contributing

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16
Q

Monogenic

A

1 gene contributing

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17
Q

Mutation

A

change in nucleotide sequence

usually detected & repaired

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18
Q

Sex chromosomes

A
  • females XX
  • males XY (X from Mum, Y from Dad)
  • X chromosomes larger -> more genes
19
Q

Diploid

A

2n (2 x 23 = 46 chromosomes)
‘double’
Non gametes

20
Q

Haploid

A

n (23 chromosomes)
‘single’
gametes

21
Q

Cell division (2 types)

A

mitosis: division of somatic (body) cells

meiosis: division of gamete (sex) cells
• eggs and sperm

22
Q

Mitosis

A

2 daughter cells
diploid
identical

asexual - for growth

23
Q

Meiosis

A

4 daughter cells
haploid
non identical

sexual - make gametes

24
Q

What is CVS and 3 components

A

cardiovascular system

heart
vessels
blood

25
Layers of the heart wall - Myocardial layers
Epicardium Myocardium Endocardium
26
What are the 4 cambers
right atrium left atrium right ventricle left ventricle
27
What are the 4 valves
aortic valve tricuspid valve pulmonary valve mitral valve
28
Coronary veins
superficial | empty into coronary sinus & right atrium
29
Major vessels (label to and from)
``` inferior vena carva superior vena carva pulmonary artery pulmonary vein arch of the aorta carotid artery thoracic aorta abdominal aorta jugular vein subclavian vein ```
30
Pressure
things move from high to low pressure - volume decrease pressure increase (& visa versa) - passive process
31
Cardiac muscle
``` muscle needs an electrical stimulus to make it work - heart has its own ‘stimulator’ - automaticity - cardiac conduction system ```
32
Sinoatrial (SA) node
the ‘pacemaker’ | in the wall of the right atrium
33
Atrioventricular (AV) node
junction between atria and ventricles
34
AV bundle
in the septum carries impulses to left and right bundle branches
35
Purkinje fibres
distribute impulse through ventricles
36
ECG stands for
ElectroCardioGram
37
What does the ECG do?
measures electrical activity that accompanies | each heart beat
38
Components of ECG's
P wave – atrial depolarisation QRS complex – ventricular depolarisation T wave – ventricular repolarisation
39
Cardiac cycle
period between start of one heartbeat and the beginning of the next includes both contraction and relaxation of both atria and ventricles
40
Phases of cardiac cycle
``` atrial systole (contraction) atrial diastole (relaxation) ventricular systole (contraction) ventricular diastole (relaxation) ```
41
Cardiac cycle - rest
atrium pressure > ventricle AV valves open ventricle pressure < artery • SL valves shut
42
Cardiac cycle - contraction (first and second sounds)
pressure in ventricle is higher than in atrium - AV valves shut to stop back flow first heart sound (lubb) - can only occur once ventricle has begun contracting and its pressure rises pressure in ventricle is higher than in artery SL valves will open to let blood out second heart sound (dubb) - can only occur once ventricle has begun to relax and its pressure drops
43
Heart sounds (list 4)
S1 – close AV valves S2 – close SL valves S3 as ventricle fills S4 atrial systole
44
Average heart rate + cardiac cycle
80-100 BPM 0.8 seconds (0.5-relaxation, 0.3-contraction)