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FNN 301 > Week 8 Type 1 Diabetes > Flashcards

Week 8 Type 1 Diabetes Flashcards

1
Q

What % of diabetics have type 1?

A

5-10%

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2
Q

in type 2 diabetes, insulin secretion may be:

A

normal
increased
decreased

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3
Q

what does insulin do?

A

insulin is an anabolic hormone - it promotes uptake into liver, muscles, and adipose tissues and promotes synthesis of proteins, trigs, glycogen

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4
Q

what are the 2 types of type 1 diabetes?

A
  1. immune mediated diabetes
  2. idiopathic diabetes
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5
Q

what is the difference between immune-mediated type 1 diabetes and idiopathic type 1 diabetes?

A
  1. immune mediated
    - the beta cells are destroyed by an autoimmune process
  2. idiopathic
    - the cause of the beta cell destruction is unknown
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6
Q

how many genes are linked to type 1 diabetes? how much inheritability do they account for?

A

50 genes are linked
account for 80-85% of inheritability

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7
Q

what are some potential triggers of type 1 diabetes?

A
  • viral infection
  • casein in cow’s milk
  • vitamin D
  • length of breastfeeding
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8
Q

risk of having celiac in those with type 1 diabetes is ______ higher compared to the general population

A

5-10x higher

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9
Q

what are the 2 main acute consequences of insufficient insulin?

A
  1. hyperglycemia
  2. ketonemia
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10
Q

what is hyperphagia

A

insatiable hunger

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11
Q

what is polydispia

A

excessive thirst

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12
Q

insulin deficiency leads to ____ glucose uptake by cells and ____ hepatic glucose output

A

decreased update by cells
increased hepatic glucose output

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13
Q

insulin deficiency leads to ____ trigs synthesis and _____ lipolysis

A

decreases trig synthesis, increased lipolysis

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14
Q

what is hypovolemia?

A

low extracellular fluid in the body

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15
Q

NEED TO REVIEW SLIDES 5-8

A
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16
Q

What is diabetic ketoacidosis?

What are the symptoms?

A

it is a severe form of hyperglycemia

Symptoms include:
- polyuria
- polydipsia
- polyphagia
- fruity breath
- nausea
- abdomen pain
- KUSSMAUL RESPIRATIONS
- lethargy

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17
Q

what are kussmaul respirations?

A

rapid, deep breathing - body is trying to eliminate excess CO2 and reduce acidic substances

a symptom of DKA

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18
Q

fruity or acetone breath is a sign of

A

DKA

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19
Q

_____ is a severe form of hyperglycemia

A

DKA

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20
Q

What is HHS?

A

hyperosmolar hyperglycemic state

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21
Q

what is the main difference between DKA and HHS?

A

DKA = ketoacidosis and hyperglycemia

HHS = severe hyperglycemia without ketoacidosis

DKA is acute, while HHS is gradual onset

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22
Q

what are the biological markers of DKA?

A
  1. pH < 7.3
  2. Bicarbonate < 15 mmol
  3. Anion gap > 12 mmol (shows if there is too much acidity in blood)
    • serum of urine ketones
  5. Plasma glucose > 14 mmol
  6. Precipitating factor
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23
Q

what are common features of DKA and HHS?

A

insulin deficiency –> hyperglycemia –> urinary loss of water and electrolytes

DONT UNDERSTAND SLIDE 13

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24
Q

what are 3 main symptoms of hyperglycemia in DKA?

what is the main sign of hyperglycemia?

A
  1. polyuria
  2. polydipsia
  3. weakness

main sign: EXFV contraction

25
what are the main symptoms of acidosis in DKA? what are the main signs?
1. hunger 2. nausea 3. vomiting 4. ab pain Signs: - kussmaul respiration, acetone odoured breath
26
why is it hard to diagnose DKA in pregnancy?
pregnant women already have high glucose
27
DONT UNDERSTAND SLIDE 16
28
what is self management education in type 1 diabetes?
an intervention that involves active patient participation in self-monitoring or decision making with the application of knowledge and skills
29
how do you treat type 1 diabetes?
exogenous insulin + nutrition therapy + physical activity
30
Insulin is classified according to 3 things:
1. onset 2. peak time 3. duration
31
Insulin dose depends on 5 things:
1. age 2. body size 3. insulin sensitivity 4. hepatic function 5. clinical judgment
32
what % of insulin taken during the day is long (basal)? What % is short?
long = 40-50% short = 50-60%
33
there are 3 types of insulin delivery regimens
1. fixed - set dose each meal 2. flexible - changing dose 3. continuous subcutaneous insulin infusion - pump
34
Humalog is this type of insulin:
bolus insulin
35
Novorapid is this type of insulin:
bolus insulin
36
lantus is this type of insulin
long acting basal
37
levemir is this type of insulin
long acting basal
38
tresiba and basaglar are this type of insulin
long acting basal
39
when does long acting insulin start to work? when does it peak?
after 90 minutes it doesnt peak
40
when does rapid acting insulin start to work? when does it peak?
starts to work after 9-20 minutes Peaks after 1-1.5 hours
40
when does short acting insulin start to work? when does it peak?
starts: 30 minutes peaks: 2-8 hours
41
when does intermediate acting insulin start to work? peak?
start to work: 1-3 hrs peak: 5-8 hrs lasts up to 18 hrs
42
it is important to councel all type 1 diabetes patients about:
hypoglycemia: recogonition, treatment, prevention
43
what is the formula for insulin requirements?
EITHER weight in lbs/4 OR weight in kg x 0.55
44
What is insulin to carb ratio? how do you know if your carb ratio is good?
how many grams of carbs 1 unit of insulin will cover. grams of carbs eaten / units of rapid acting insulin taken if your carb ratio is good, your blood sugar should rise 2 to 4 mmol/L 2 hours after eating.
45
if you have a good carb ratio, how much do you want your blood sugar to rise 2 hours ater eating?
2-4 mmol/L
46
what is the equation for insulin to carb ratio?
grams of carbs eat / units of rapid-acting insulin taken
47
how do you calculate how many insulin units you need?
of grams of carbs at a meal / the carb ratio number
48
what are the benefits of continuous subcutaneous insulin infusion? aka pump?
1. gives small improvements to A1C compared to basal bolus injections 2. gives improved treatment satisfaction and diabetes specific QOL 3. reduced SEVERE hypoglycemia if there is a high baseline rate of severe hypoglycemia - but nonsevere and nocturnal hypoglycemia remain unchanged
49
does ontario cover insulin pump?
yes - for kids and adults with type 1 government also gives $200 in supplies
50
how do people qualify for pump coverage for type 1 diabetes by ontario government?
1. part of diabetes education program 2. prove SMBG - test 4x per day 3. DKA and hypoglycemia prevention education
51
what are the 6 pros of CSII
1. flexibility 2. improved QOL 3. more accurate dosing 4. fewer needle pokes 5. easier to plan for exercise 6. easier to bolus
52
what are the 5 cons of CSII?
1. always attached 2. technology 3. more education (need to know how to count carbs and manage exercise) 4. cost 5. troubleshooting
53
what are the benefits of CGM?
1. improved A1C with no increase in hypglycemia 2. improved QOL also, if using sensory -augmented pump (SAP) therapy with nocturnal hypoglycemia, using SAP with low glucose suspend provides a reduction in nocturnal hypoglycemia with no A1C increase
54
what are 10 recommendations for managing type 1?
1. use basal-bolus injections or pump 2. use rapid acting insulin analogues in place of regular insulin to improve a1c and minimize hypoglycemia 3. use a long acting insulin instead of intermediate acting insulin to reduce hypoglycemia (use degludec instead of detemir) 4. need counselling about the risk and prevention of hypoglycemia 5. do the following items to reduce hypoglycemia: use a standardized eudcation program, increased frequency of SMBG, CGM with high sensor adherence in pump patients, and less strngent glycemic targets 6. in people using basal bolus who are not hitting targets, try pump with or without CGM 7. pump may improve satisfaction, and pump + CGM may improve QOL 8. pump patients should undergo periodic evaluations to determine if its still appropriate 9. CGM can help improve or maintain A1C regardless of insulin delivery method 10. if you experience nocturnal hypoglycemia and use pump and CGM, SAP with low glucose suspend may be chosen over SAP alone to reduce hypoglycemia
55
what are the preferred insulin routines for adults with type 1 diabetes?
basal bolus switch to pump if glycemic targets are not met
56
who should be counselled about the risks of hypoglycemia?
all type 1 paitents
57
what is the nutrition checklist for type 1 diabetes?
1. REFER for nutrition counselling 2. FOLLOW canada food guide 3. INDIVIDUALIZE dietary advice 4. CHOOSE low glycemic index carbs 5. KNOW alt diet patterns 6. ENCOURAGE matching insulin to carbs for type 1 7. ENCOURAGE nutritionally balanced, calorie-reduced diet
58
List 4 diabetes resources
1. just the basics 2. beyond the basics 3. glyceminc index educational portal 4. diabetes exchange lsit

FNN 301 (10 decks)

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