Weight Loss

Question 1

drugs/conditions that can cause weight gain

Answer 1

antipsychotics, diabetes drugs (insulin, meglitinides, SU, thiazolidines), Divalproex/valproic acid, gabapentin, pregabalin, lithium, mirtazapine, steroids, TCAs

*hypothyroidism

Question 2

drugs/conditions that can cause weight loss

Answer 2

ADHD drugs, bupropion, GLP-1 agonists, pramlinitide, roflumilast, SGLT2 inhibitor, topiramate

*hyperthyroidism, celiacs disease, IBD

Question 3

Weight loss drugs in certain conditions

Answer 3

-pregnancy: avoid all
-HTN: avoid Contrave (Naloxone/Buproprion) and caution with Qysima (phentermine/topiramate)
-depression: caution in young adults and adolescents with Contrave
-seizures: avoid Contrave and caution with Qysima
-taking opioids: avoid contrave

Question 4

Phentermine

Answer 4

sympathomimetic (stimulant)

Question 5

Qysima

Answer 5

REMS program due to teratogenic risk
-vision problems, insomnia, tachycardia
-taper off due to risk of seizures

Question 6

Contrave

Answer 6

-CI: pregnancy, opioids, uncontrolled HTN, seizure disorder, other buproprion-containing medications

Question 7

liraglutide (Saxenda, victoza) & semaglutide (wegovy, ozempic)

Answer 7

pancreatitis, hypoglycemia, nausea

Question 8

Orilstat (Xenical (Rx) and Alli (OTC))

Answer 8

take multivitamins at bedtime or separated by > 2 hours