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Flashcards in Women's Health Med Review Deck (44):
1

Estradiol Trade Name

Estrace (oral)

2

Estradiol Category

Oral Estrogen Derivative

3

Estradiol Use

Menopause

4

Estradiol Dose

0.5-1 mg PO qday

5

Estradiol AE

Common: Nausea, headache, bloating, breast tenderness, bleeding

Serious: CHD, stroke, VTE, breast CA, gallbladder disease

CI: Hx of/active thromboembolic disease; breast cancer or estrogen-dependent neoplasm; pregnancy; liver disease, undiagnosed vaginal bleeding; prevention of treatment of cardiovascular disease, cerebrovascular disease, or dementia

Preg Cat: X

6

Medroxyprogesterone Acetate (MPA) Trade Name

Provera

7

Medroxyprogesterone Acetate Category

Oral Progestrogen; Contraceptive

8

Medroxyprogesterone Acetate Use

Menopause

9

Medroxyprogesterone Acetate Dose

2.5-10 mg PO qday

10

Medroxyprogesterone Acetate AE

Common: nausea, headache, weight gain, bleeding, irritability, depression

Serious: VTE, decreased BMD; may cause increased risk of breast cancer when used continuously with estrogen

CI: Hx of/active thromboembolic disease; breast cancer or estrogen-dependent neoplasm; pregnancy; liver disease, undiagnosed vaginal bleeding; prevention of treatment of cardiovascular disease, cerebrovascular disease, or dementia

Preg Cat: X

11

Estradiol Transdermal Trade Name

Alora, Climara, Estraderm, Vivelle, Vivelle Dot

12

Estradiol Transdermal Category

Transdermal estrogen

13

Estradiol Transdermal Use

Menopause

14

Estradiol Transdermal Dose

0.025-0.05 mg patch, changed weekly (Climara) or changed twice weekly

15

Estradiol Transdermal AE

Common: Nausea, headache, bloating, breast tenderness, bleeding

Serious: CHD, stroke, VTE, breast CA, gallbladder disease

CI: Hx of/active thromboembolic disease; breast cancer or estrogen-dependent neoplasm; pregnancy; liver disease, undiagnosed vaginal bleeding; prevention of treatment of cardiovascular disease, cerebrovascular disease, or dementia

Preg Cat: X

16

Estradiol + Norethidrone Transdermal Trade Name

CombiPatch

17

Estradiol + Norethidrone Transdermal Category

Combination Transdermal Estrogen/Progestogen

18

Estradiol + Norethidrone Transdermal Use

Menopause

19

Estradiol + Norethidrone Transdermal Dose

0.05/0.14 - 0.05/0.25 mg per 24 hours; apply one patch twice weekly

20

Estradiol + Norethidrone Transdermal AE

ESTROGEN:
Common: Nausea, headache, bloating, breast tenderness, bleeding

Serious: CHD, stroke, VTE, breast CA, gallbladder disease

PROGESTOGEN:
Common: nausea, headache, weight gain, bleeding, irritability, depression

Serious: VTE, decreased BMD; may cause increased risk of breast cancer when used continuously with estrogen

CONTRAINDICATIONS:
Hx of/active thromboembolic disease; breast cancer or estrogen-dependent neoplasm; pregnancy; liver disease, undiagnosed vaginal bleeding; prevention of treatment of cardiovascular disease, cerebrovascular disease, or dementia

Preg Cat: X

21

Norgestimate/Ethinyl Estradiol (EE) Trade Name

Sprintec

22

Norgestimate/Ethinyl Estradiol Category

Combination Oral Contraceptive (COC); Monophasic w/IM estrogen

23

Norgestimate/Ethinyl Estradiol Use

Contraception

24

Norgestimate/Ethinyl Estradiol Dose

0.25mg/35mcg PO qday

25

Norgestimate/Ethinyl Estradiol AE

AE: Increased risk thromboembolism and stroke; may elevate BP; estrogenic and progestin side effects (nausea, breast tenderness, melasma, headache, breakthrough bleding, increased spotting, hypomenorrhea, fatigue, mood changes, increased appetite, weight gain, acne, oily skin, hirsutism, increased LDL, decreased HDL)

CI:
Absolute: Hx thromboembolic disease, stroke, CAD, breast cancer, estrogen-dependent neoplasm; undiagnosed abnormal uterine bleeding, hepatic tumors; pregnancy; heavy smokers >15 cigs/day over age 35; active liver disease; migraine HA with focal neuro sxs; postpartum during first 21 days as well as days 21-42 in women with additional TE risk factors

26

Raloxifene Trade Name

Evista

27

Raloxifine Category

2nd Generation Mixed Estrogen Agonist/Antagonist (MEAA)

28

Raloxifine Use

Post-menopausal Osteoporosis (60mg PO qday)

29

Raloxifine AE

Generally well tolerated; may cause leg cramps and hot flushes; risk for VTE similar to estrogens

30

Alendronate Trade Name

Fosomax

31

Alendronate Category

Bisphosphonate

32

Alendronate Use

Prevention of post-menopausal (PM) osteoporosis; Osteoporosis; Glucocorticoid-induced osteoporosis

33

Alendronate Dose

Prevention of PM osteoporosis: 5mg PO qday or 35mg PO qweek (Take after an overnight fast with a full glass of water while sitting or standing upright at least 30 minutes prior to morning meal; do not lie down for 30 minutes after administration; do not take with other meds or fluids; do not chew or suck on the tablet.)

Osteoporosis: 10mg PO qday or 70mg PO qweek

Steroid-induced: 10mg PO qday

34

Alendronate AE

AE: Nausea; heartburn; GI pain; irritation; perforation; ulceration and/or bleeding; transient flu-like illness; muscle pains; possible risk of atypical femur fracture; possible slight increase in esophageal cancer; black box warning for rare osteonecrosis of the jaw; unproven risk of Afib.

**Avoid when CrCl <35mL/min

35

Calcium Carbonate Trade Name

Tums, Os-Cal, Caltrate, One-A-Day Women's MVI, Rolaids, Viactiv

36

Calcium Carbonate Category

Calcium supplement

37

Calcium Carbonate Use

Osteoporosis

38

Calcium Carbonate Dose

1200-1500 mg PO qday elemental calcium divided into 500-600 mg doses during or after meals low in fiber to increase absorption

39

Calcium Carbonate AE

AE: constipation; GI irritation; flatulance; rare kidney stones; increased Ca++

40

Calcitonin Trade Name

Miacalcin

41

Calcitonin Category

Calcitonin

42

Calcitonin Use

PM Osteoporosis; Useful for painful compression fractures; Decrease corticosteriod-induced osteoporosis

43

Calcitonin Dose

200 IU intranasal qday (nasal spray); Alternate nostrils on a daily basis

44

Calcitonin AE

AE: May cause rhinitis, epistaxis, local irritation