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Flashcards in Wound Healing Deck (16)
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1

What are the three layers of skin?

Epidermis - dead
Dermis - Alive
Hypodermis - protection layer

2

What are the two phases of wound healing?

Haemostasis - clotting
Tissue repair

3

Describe the haemostasis phase of wound healing

1) blood coagulation cascade - exposure of blood to extra vascular tissue activates platelets and they form a plug
2) Platelet plug strengthened by fibrin
3) Fibrinous clot acts as a mix for migration of inflammatory and tissue repair cells into the wound

4

Describe the inflammation (tissue repair) phase of wound healing

1) 0-4 days
2) Early phase (haemostasis): vasoconstriction, vasodilation, coagulation.
3) Late phase: recruitment and activity of inflammatory cells.
4) A vascular and cellular response
5) Local capillaries become more permeable and inflammatory exudate infiltrates surrounding tissues

5

Describe the Reconstruction (tissue repair) phase of wound healing

1) 2-24 days
2) Angiogenesis - new blood vessel growth
3) Granulation - new skin (red)
4) Contraction - Wound edges contract together
5) Epitheliasation - Pale pink skin

6

Describe the maturation (tissue repair) phase of wound healing

1) 24-365 days
2) Scar tissue remodeled and strengthened by synthesis of collagen and elastin

7

What are examples of aberrant wound healing?

Hypergranulation
Contracture
Hypertrophic scar
Keloid

8

Describe an acute wound

1) a wound that heals by primary intention
2) a traumatic or surgical wound which heals by secondary intention
3) Proceeds through an orderly and timely reparation process that results in sustained restoration of anatomical integrity

9

Describe a chronic wound

1) Reparative process does not proceed through an orderly and timely process
2) complicated and delayed by intrinsic and extrinsic factors that impact on THE PERSON, THEIR ENVIRONMENT & THE WOUND

10

What are the biochemical characteristics of a healing wound?

- Decreased pro-inflammatory cytokine
- decreased matrix metaloproteinases
- increased growth factor
- cells capable of rapid response
- increased cell mitosis

11

What are the biochemical characteristics of a chronic wound?

- increased pro inflammatory cytokins
- increased matrix metaloproteinases
- varied levels of growth factors
- senescent cells
- decreased mitogenic activity

12

What are systemic signs of infection

- Elevated temperature
- Tachycardia
- Rigor
- Malaise
- Elevated leukocytes

13

Define critical colonisation

- Increased bacterial burden
- Bacterial Imbalance
- Covert infection
- Local injection
- Topical infection

14

What are two reactions to threats

1) Adaption - develop resistance
2) Self-protection - forms biofilm

15

Define Inherent bacterial resistance

Bacteria is naturally resistant to the antimicrobial agent

16

Define Acquired bacterial resistance

Bacteria develops resistance through bacterial genome, through vertical evolution (a mutation of the organism) or horizontal evolution (genetic transfer of resistant genes from one bacterium to another.