010715 stomach dis 4 Flashcards Preview

Gastrointes > 010715 stomach dis 4 > Flashcards

Flashcards in 010715 stomach dis 4 Deck (24):
1

shape of H pylori

spiral shaped

2

where does H pylori colonize exchlusively

gastric type epithelium

3

effects of H pylori colonization

stimulates inflammatory responses

4

hallmark of H pylori

neutrophilic infiltration
along with lymphocytes, plasma cells, macrophages

5

where does early stage h pylori gastritis occur

confined to ANTRUM

6

mechanism of h pylori in causing ulcers in its early stage

inhibits D cell somatostatin secretin so gastrin secretion is increased

acid secretion is increased, causing ulcers

7

late stage of chronic h pylori gastritis occurs where

inflammation expands to CORPUS/FUNDUS

8

mechanism of h pylori in causing ulcers in the late stage

in corpus/fundus, destroys parietal cells
decreased acid production causes gastrin increase

9

how to diagnose h pylori infec?

serology (false positive b/c persists even after eradication)

endoscopic gastric mucosa biopsy
urea breath test
stool antigen test
false negative with recent antibiotics or PPI therapy

10

adverse effects of h pylori infection

peptic ulcer
enteric infections
malnutrition (iron and B12 deficiency)
gastric neoplasia (adenocarcinoma, MALT lypmphoma, carcinoid)

11

autoimmune gastritis

inherited form is associated with immune response in oxyntic mucosa against parietal cells and IF

12

histology of autoimmune gastritis

lymphocytic inflam with destruc of parietal cells

13

atrophic metaplastic gastritis

could be in body and fundus or antrum:
autoimmune
vs
H pylori

14

gastritis vs gastropathy

gastritis: INFLAM associated mucosal injury (infectious, autimmune)

gastrophathy: epithelial cell damage and regeneration with MINIMAL OR NO ASSOCIATED INFLAM (bile, alcohol, aspirin, NSAIDs, ischemia)

15

ulcer

destructive breach of mucosa that extends below muscularis mucosa

16

erosion

destruction superficial to muscularis mucosa

17

peptic ulcer disease-what are some causes?

90% due to
aspirin/NSAIDs (can directly cause rapid cell death and superficial mucosal injury in addition to reduced prostaglandin)

H pylori
surreptitious or unaware NSAID use

18

complications of peptic ulcer disease

acute GI hemorrhage
chronic GI blood loss or iron def anemia
perforation, peritonitis, pancreatitis
gastric outlet obstruction
gastointestinal fistula
malabsoprtion

19

symptoms of peptic ulcer dis

chronic dyspeptic epigastric pain
acute severe pain--indicates perforation
nausea
anorexia, weight loss
hematemesis
melena
recurrent postprandial vomiting (obstruction)
diarrhea (fistula)

or no symptoms

20

dyspepsia

discomfort in upper abdomen

21

anion gap acidosis can occur with

NSAID s

22

ulcers can cause edema causing obstruction-true or false?

true

23

salicylate

aspirin

24

octreotide scan

to look for carcinoids and other tumors, sarcoidosis