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Flashcards in 010715 stomach dis 5 Deck (11):
1

epidemiology of gastric adenocarcinoma in the world

higher incidence in developing countries
higher risk with higher geographic latitudes
risks: smoking, salt, nitrates

2

epidemiology of gastric adenocarcinoma in US

more common w Asian, Hispanic, black ethnicity
men, older aged

3

types of gastric adenocarcinoma

intestinal type (distal stomach, H pylori main risk factor, bakcground of intestinal metaplasia with precursors from bone marrow)

diffuse type (precursor lesion unknown, younger age, not H pylori related, signet ring cell histology, more aggressive)

hereditary diffuse type (E cadherin mutation)

diffuse type EBV-associated

adenocarcinoma of cardia

4

clinical presentation of gastric adenocarcinoma

abd pain
early satiety and nausea
weight loss
dysphagia
vomiting
gastrointestinal bleeding/perforation

5

gastric lymphoma is strongly associated with

H pylori

6

gastric carcinoid tumors

derived from ECL cells
proliferate and transform in response to high circulating levels of GASTRIN (high gastrin due to atrophic gasritis or ectopic gastrin secretion)

7

course of gastric carcinoid tumor

usually indolent and benign

8

carcinoid

a neuroendocrine tumor

9

atrophic metaplastic gastritis

inflam destruction of normal mucosa with replacement by metaplastic elements (commonly intestinal type with goblet cells)

type A-body and fundus (autoimmune)
type B-antrum (H pylori)

10

atrophic metaplastic gastritis can have increased what?

gastrin

11

tx for gastric carcinoid tumor?

antrectomy to remove gastrin