Flashcards in 02 Principles of Cancer Treatment Wolf Deck (5)
What is important to remember about the differences between experimental animal models and human tumors?
Animal tumors are generally homogeneous; human tumors are mostly heterogeneous
What is "collateral damage" in cancer treatment?
Due to cell similarity, agents used in the treatment of cancer can also affect non-cancerous cells
What do Antiangiogenic agents do?
Cut off the blood supply. If we can "starve" the cancer cells, proliferation will stop and existing cells will "starve"
How is anticancer drug testing inherently different in Phase I than the testing of drugs that are not cytotoxic?
Phase I is for determining toxicity and the MTD (Maximum toelrated dose: can only be done on cancer patients). Phase II is for determining antitumor effects and spectrum of action. Phase III is for comparing new drug with existing treatment options