Flashcards in 24 General Therapy Overview Deck (26)
What chemotherapy is used to treat SCLC?
EP + RT (Etoposide + Cisplatin + Radiation therapy)
What is treatment of choice for NSCLC Stage I, II, IIIa?
Surgery w/ curative intent
What chemotherapy is used for NSCLC Stage II, IIIa?
What is first line treatment for NCSLC Stage IIIb, IV, metastatic?
Carboplatin-Paclitaxel + Bevacizumab
What is used in lung cancer for EGFR (+)?
What is used in lung cancer for ALK (+)?
What is the first line hormonal therapy for Prostate Cancer?
GnRH agonist (Leuprolide, Goserelin) +/- Anti-androgen (CAB)
What are the anti-androgens used in prostate cancer?
Bicalutamide (Casodex), Flutamide (Eulexin), Nilutamide (Nilandron)
What is the first line chemotherapy for metastatic Prostate Cancer?
Docetaxel + Prednisone
What is the most common adjuvant chemotherapy for breast cancer?
AC --> Paclitaxel (T). Anthracycline (Doxorubicin) + Cyclophosphamide x4 cycles (3 weeks each) --> Paclitaxel IV weekly x12 weeks +/- Traztuzumab (Her2) IV weekly x1 year
What adjuvant chemotherapy can be used for breast cancer in a patient with nodal involvement and possible underlying cardio issues?
TC +/- H. Docetaxel + Carboplatin x6 cycles (3 weeks each) +/- Trastuzumab x1 year
What adjuvant therapy is used for Her2 (+) breast cancer?
Traztuzumab (Herceptin) or Pertuzumab (Perjeta)
What is the most common first line adjuvant therapy for ER (+) breast cancer?
Tamoxifen (Saltamox) - most common anti-estrogen used
What is the NCCN recommended therapy for resected Adjuvant Stage II Colon cancer?
What is the NCCN recommended therapy for resected Adjuvant Stage III Colon cancer?
FOLFOX (repeat Q2 weeks) for 6 months
What is in FOLFOX?
What is the NCCN recommended therapy for advanced metastatic colon cancer?
FOLFOX + Bevacizumab
What are the first line agents for renal cell cancer?
TKIs: Sorafenib (Nexavar), Sunitinib (Sutent). Temsirolimus (Torisel). IL-2 (Proleukin)
What is the standard therapy for Acute Myelogenous Leukemia (AML) Induction (< 60 yo)?
Combination of Cytarabine + Anthracycline (1-2 cycles). "7+3": Cytarabine on days 1-7, and Idarubicin or Daunorubicin on days 1-3
What is the only curative therapy for Chronic Myelogenous Leukemia (CML)?
Allogeneic stem cell transplant
What is 1st line treatment for CML?
TKIs: Dasatinib, Nolitnib > Imatinib
What is the main agent used for Multiple Myeloma?
Thalidomide (Thalomid). Bortezomib (Velcade) is also a first line choice
Treatment option for aggressive Non-Hodgkin's Lymphoma (NHL)?
R-CHOP, repeat every 21 days
What is R-CHOP?
Rituximab (Rituxan). Cyclophosphamide (Cytoxan). Hydroxyl Daunorubicin. Vincristine (Oncovin). Prednisone
What is the gold standard for HD treatment?
ABVD: Days 1 and 15 every 28 days for 6-8 cycles