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Flashcards in 24 General Therapy Overview Deck (26):
1

What chemotherapy is used to treat SCLC?

EP + RT (Etoposide + Cisplatin + Radiation therapy)

2

What is treatment of choice for NSCLC Stage I, II, IIIa?

Surgery w/ curative intent

3

What chemotherapy is used for NSCLC Stage II, IIIa?

ADJUVANT Cisplatin-based

4

What is first line treatment for NCSLC Stage IIIb, IV, metastatic?

Carboplatin-Paclitaxel + Bevacizumab

5

What is used in lung cancer for EGFR (+)?

Erlotinib

6

What is used in lung cancer for ALK (+)?

Crizotinib

7

What is the first line hormonal therapy for Prostate Cancer?

GnRH agonist (Leuprolide, Goserelin) +/- Anti-androgen (CAB)

8

What are the anti-androgens used in prostate cancer?

Bicalutamide (Casodex), Flutamide (Eulexin), Nilutamide (Nilandron)

9

What is the first line chemotherapy for metastatic Prostate Cancer?

Docetaxel + Prednisone

10

What is the most common adjuvant chemotherapy for breast cancer?

AC --> Paclitaxel (T). Anthracycline (Doxorubicin) + Cyclophosphamide x4 cycles (3 weeks each) --> Paclitaxel IV weekly x12 weeks +/- Traztuzumab (Her2) IV weekly x1 year

11

What adjuvant chemotherapy can be used for breast cancer in a patient with nodal involvement and possible underlying cardio issues?

TC +/- H. Docetaxel + Carboplatin x6 cycles (3 weeks each) +/- Trastuzumab x1 year

12

What adjuvant therapy is used for Her2 (+) breast cancer?

Traztuzumab (Herceptin) or Pertuzumab (Perjeta)

13

What is the most common first line adjuvant therapy for ER (+) breast cancer?

Tamoxifen (Saltamox) - most common anti-estrogen used

14

What is the NCCN recommended therapy for resected Adjuvant Stage II Colon cancer?

5-FU/Leucovorin

15

What is the NCCN recommended therapy for resected Adjuvant Stage III Colon cancer?

FOLFOX (repeat Q2 weeks) for 6 months

16

What is in FOLFOX?

Oxaliplatin, 5-FU/Leucovorin

17

What is the NCCN recommended therapy for advanced metastatic colon cancer?

FOLFOX + Bevacizumab

18

What are the first line agents for renal cell cancer?

TKIs: Sorafenib (Nexavar), Sunitinib (Sutent). Temsirolimus (Torisel). IL-2 (Proleukin)

19

What is the standard therapy for Acute Myelogenous Leukemia (AML) Induction (< 60 yo)?

Combination of Cytarabine + Anthracycline (1-2 cycles). "7+3": Cytarabine on days 1-7, and Idarubicin or Daunorubicin on days 1-3

20

What is the only curative therapy for Chronic Myelogenous Leukemia (CML)?

Allogeneic stem cell transplant

21

What is 1st line treatment for CML?

TKIs: Dasatinib, Nolitnib > Imatinib

22

What is the main agent used for Multiple Myeloma?

Thalidomide (Thalomid). Bortezomib (Velcade) is also a first line choice

23

Treatment option for aggressive Non-Hodgkin's Lymphoma (NHL)?

R-CHOP, repeat every 21 days

24

What is R-CHOP?

Rituximab (Rituxan). Cyclophosphamide (Cytoxan). Hydroxyl Daunorubicin. Vincristine (Oncovin). Prednisone

25

What is the gold standard for HD treatment?

ABVD: Days 1 and 15 every 28 days for 6-8 cycles

26

What is ABVD?

Doxorubicin (Adriamycin). Bleomycin (Blenoxane). Vinblastine (Velban). Decarbazine (DTIC)