1-24 Mechanisms of Antibiotics Flashcards Preview

MSI Unit I > 1-24 Mechanisms of Antibiotics > Flashcards

Flashcards in 1-24 Mechanisms of Antibiotics Deck (16):
1

What is the mechanism of action and whether the agent is -cidal or -static:

Penicillin

B-lactam...target cell wall synthesis by irreversibly binding PBP and preventing cross-linking of peptidoglycan layer

-cidal

2

What is the mechanism of action and whether the agent is -cidal or -static:

Cephalosporins

B-lactam...target cell wall synthesis by irreversibly binding PBP and preventing cross-linking of peptidoglycan layer

-cidal

3

What is the mechanism of action and whether the agent is -cidal or -static:

Glycopeptides

Target cell wall synthesis by preventing cross-linking of peptidoglycan

-cidal

4

What is the mechanism of action and whether the agent is -cidal or -static:

Macrolides

Prevents protein sysnthsis (block formation of growing protein)

-static

5

What is the mechanism of action and whether the agent is -cidal or -static:

Tetracyclines

Prevent protein synthesis (block tRNA attachment)...not good for kids

-static

6

What is the mechanism of action and whether the agent is -cidal or -static:

Fluoroquinolones

Interfere with DNA supercoiling (ciproflaxin)

-cidal

7

What is the mechanism of action and whether the agent is -cidal or -static:

Aminoglycosides

Prevent protein synthesis

-cidal

8

What is the mechanism of action and whether the agent is -cidal or -static:

Sulfoamindes/trimethoprim

target two diff points in folate synthesis pathway...if used together it is bacteriocidal

9

Which class of antibiotics target cell wall synthesis?

Penicillins
Cephalosporins
Glycopeptides

10

Which class of antibiotics target/prevent protein synthesis?

Macrolides
Tetracyclines
Aminoglycosides

11

Which class of antibiotics interfere with nucleic acid synthesis/supercoiling?

Fluoroquinolones

12

Which class of antibiotics (that we covered in class) are mainly bacteriostatic?

Macrolides
Tetracyclines

13

What is the major function of Vancomycin

Vancomycin is a Glycopeptide and therefore disrupts cell wall synthesis.

Only effective against gram + organisms
The gram - bacterias are resistant due to LPS porons

14

a 34-year-old man recently diagnosed with streptococcal pharyngitis started a treatment with amoxicillin, two tablets daily. Which of the following statements best explains a prominent feature of the antibacterial action of this beta-lactam antibiotic?

Blocks the action of penicillin binding proteins preventing cross linking of the peptidoglycan sheets.

15

A 42-year old man recently diagnosed with pneumonia due to Klebsiella pneumonia was started on a treatment with fluoroquinolone (levoflaxacin), two tablets daily. Which of the following molecular actions most likely mediated the therapeutic effects of the drug in the patient's disease?

inhibition of relaxation of supercoiled bacterial DNA

16

What is the mechanism of action of the glycopeptides?

The glycopeptides bind to the substrate of the transpeptidation enzyme and disrupt the cell wall construction

Decks in MSI Unit I Class (52):