Flashcards in 1-24 Mechanisms of Action of Antibiotics Deck (20):
slows the growth of bacteria
5 modes of action of antibiotics. example of each
1. inhibition of cell wall synthesis - beta lactams
2. inhibition of protein syntehsis - tetracyclines targeting 30s
3. alteration cell membranes - lipopeptides
4. inhibition of nucleic acid synthesis ( fluoriquones block DNA gyrase)
5. antimetabolite activity (sulfas inhibit synthesis pathway)
bacteriocidal, irreversibly binds PBP's preventing further cell wall synthesis
same as penicillins, resist beta lactamase as generations progress.
irreversibly binds PBP's - preventing further cell wall synthesis
binds to the short amino acid residues hanging off the glycan strands. blocks PBP's from crosslinking to create cell wall
targets the ribosomal subunit (large), preventing protein synthesis
bacterioSTATIC, targets ribosomal subunit (Small)
bacteriocidal agent, interfers with DNA gyrase activity (can no longer supercoil)
inhibits nucleic acid (DNA) synthesis
bacteriocidal that targets ribosomal subunites, preventing protein synthesis
bacterioSTATIC, inhibits folate syntehsis pathway.
Bactrim - trimethoprim & sulfamethoxazole given together become bacteriocidal. each blocks a portion of the folate pathway.
describe how pharmokenetic and pharmodynamic properties may influence whether an antibiotic may or may not be used in treatment of an infection
pharmokinetic - if the antibiotic has toxcitiy at the concentration needed to be effective. Also how often the drug must be given. describes the way the body manupulates the drug
Pharmodynamic - if the antibiotic simply can't reach the concentration necessary to effect bacteria then the antibiotic will have no effect.
describes the biochemical/physiological effects of teh drug and mechanism of action on bacteria
four main beta lactam classes
penicillins, cephalosporins, monobactams, carbapenems
cidal - inhibits muramic acid synthesis (cell wall)
static - blocks formation of translation initiation complex
prevents peptide bond formation
disrupts DNA synthesis
inhibits RNA synthesis
inhibits RNA transcription