1-24 Mechanisms of Action of Antibiotics Flashcards Preview

MSI Unit I > 1-24 Mechanisms of Action of Antibiotics > Flashcards

Flashcards in 1-24 Mechanisms of Action of Antibiotics Deck (20):
1

Bacteriostatic

slows the growth of bacteria

2

bacteriocidal

kills bacteria

3

5 modes of action of antibiotics. example of each

1. inhibition of cell wall synthesis - beta lactams
2. inhibition of protein syntehsis - tetracyclines targeting 30s
3. alteration cell membranes - lipopeptides
4. inhibition of nucleic acid synthesis ( fluoriquones block DNA gyrase)
5. antimetabolite activity (sulfas inhibit synthesis pathway)

4

Penicillin

bacteriocidal, irreversibly binds PBP's preventing further cell wall synthesis

5

cephalosporins

same as penicillins, resist beta lactamase as generations progress.

irreversibly binds PBP's - preventing further cell wall synthesis

6

glycopeptides

Vancomycin, bacteriocidal

binds to the short amino acid residues hanging off the glycan strands. blocks PBP's from crosslinking to create cell wall

7

macrolides

bacterioSTATIC

targets the ribosomal subunit (large), preventing protein synthesis

8

Tetracyclines

bacterioSTATIC, targets ribosomal subunit (Small)

9

fluoroquinolones

bacteriocidal agent, interfers with DNA gyrase activity (can no longer supercoil)

inhibits nucleic acid (DNA) synthesis

10

aminoglycosides

bacteriocidal that targets ribosomal subunites, preventing protein synthesis

11

sulfonamides

bacterioSTATIC, inhibits folate syntehsis pathway.

Bactrim - trimethoprim & sulfamethoxazole given together become bacteriocidal. each blocks a portion of the folate pathway.

12

describe how pharmokenetic and pharmodynamic properties may influence whether an antibiotic may or may not be used in treatment of an infection

pharmokinetic - if the antibiotic has toxcitiy at the concentration needed to be effective. Also how often the drug must be given. describes the way the body manupulates the drug

Pharmodynamic - if the antibiotic simply can't reach the concentration necessary to effect bacteria then the antibiotic will have no effect.
describes the biochemical/physiological effects of teh drug and mechanism of action on bacteria

13

four main beta lactam classes

penicillins, cephalosporins, monobactams, carbapenems

14

fosfomycin

cidal - inhibits muramic acid synthesis (cell wall)

15

linezolid

static - blocks formation of translation initiation complex

16

chloramphenicol

prevents peptide bond formation

17

metronidazole

disrupts DNA synthesis

18

rifampin

inhibits RNA synthesis

19

bactitracin (topical)

inhibits RNA transcription

20

muprocin

blocks tRNA synthesis, eradicates MRSA

Decks in MSI Unit I Class (52):