Flashcards in 1-9 Antibody Structure and Function Deck (23)
What does the variable (v) region of the immunoglobin do?
What does the hypervariable regions do?
Variable region allows for antigen binding
Hypervariable region have sequences for more specific antigen interactions
Where are the Fab regions located on the immunoglobulin and what are they made up of?
Fab region is the part of the immunoglobulin where the protein branches into 2 arms (V-shaped), with each arm composed of one light chain on the outside and part of the heavy chain on the inside
What is the Fc region, what is it responsible for, and where on the immunoglobulin is it located?
The Fc region is located at the base of the immunoglobulin (stem of Y) and contains specific antigen determinants...it is composed of the remaining parts of the 2 heavy chains
It interacts with cell surface receptors (Fc receptors) which allows for the activation of the immune response
What is the most common type of immunoglobulin?
What is the most primitive type of immunoglobulin and unable to directly mediate opsonization and antibody-dependent cell-mediated cytotoxicity (ADCC)?
Which immunoglobulin has the widest range of functions?
Which immunoglobulin exists in two forms, one of which is secreted, with the secreted form containing a "secretory piece" that inhibits degradation?
Which immunoglobulin is associated with immune response to parasites and is involved in allergic reactions?
Type of Immunoglobulin found in milk?
IgA or "IgAs"
least common immunoglobulin?
immunoglobulin with greatest serum level?
immunoglobulin that can transport across epithelium
immunoglobulin that diffuses best into extravascular sites
the IgG's (1-4)
can transport across placenta. importance?
IgG - baby will have IgG without ever having been epxposed
can be a monomer or a pentamer
Functions of IgG
toxin neutralizing, agglutinating, opsonizing, bacteriolyic (with aid of complement)
can be found as a dimer
mediates changes in vascular permeability
located on surface of immature b-lymphotyctes
IgD, coexpressed with IgM
the heavy chain (crystallized) or (constant). contains more of the antigenic determinants
retains ability to bind antigen and not crystallized (more variable)
what does the Fc receptor of macrophages bind to?
the IgG constant region