Haldane's Rule Flashcards Preview

MSI Unit I > Haldane's Rule > Flashcards

Flashcards in Haldane's Rule Deck (5):
1

three requirements for haldane's rule to apply

x linked recessive

reduced fitness (genetic lethal)

-negative relevant family history

2

what are excluded?

x linked diseases caused by dynamic mutations, such as fragile x

3

what does haldane's rule explain?

why not all mothers of x-linked recessive disorder sons are carriers themselves

4

classic example?

DMD where fitness = 0

5

the proportion of new mutations amoung affected males will be...

1/3, and only 2/3 of the mothers will be carriers

only applies if ftiness is low (0)

u must equal v, aka, female and male mutaton rate must be the same

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