1-3. Inflammation/ Neoplasia Pathoma Flashcards Preview

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Flashcards in 1-3. Inflammation/ Neoplasia Pathoma Deck (34):
1

What CD receptor do neutrophils express

CD14

2

What role does PGI have

PGI = Platelet gathering inhibitor

3

What role do Mast Cells have

Release HistamineVasodilation and increase vascular permeability

4

What is the second phase response of Mast Cells

Recruit Leukotrienes

5

4 Mediators that call in Neutrophils

LTB4, C5A, IL-8, bacteria products

6

Classical compliment system

(ig) GM makes Classic cars (C1)

7

Pathway/end result of compliment system

C3, C5, generation of membrane attack complex (MAC)

8

What components of compliment system trigger mast cell degranulation

C3a and C5a

9

one role of C5 in the compliment system

Calls in neutrophils

10

What does bradykinin do?

Same thing as histamineincrease vasodilation, vascular permeability (++pain)

11

Prostaglandin E2

E2fEEEEEver and pain

12

mediators that macrophages release

TNF-g, IL-1Stimulate cox for PGE2for fever

13

Leukocyte migration and rollingwhat are the binding factors

E-selectin, P-selectinBinds the Sialyl-Lewis

14

Leukocyte adhesion of vessel wall

ICAM (intercellular adhesion molecule)

15

Delayed separation of umbilical cord

Leukocyte adhesion deficiency (LAD)CD18

16

Lack of pus formation

Leukocyte adhesion Deficiency

17

Impaired phagolysosome formation

Chediak-Higashi

18

Whats the mechanism of O2 to HOCl (bleach) in a phagocyte degredation

O2 --> O2- --> H2O2 --> HOCL

19

What is the defect in Chronic Granuloma Dz (CGD) aka poor O2 dependent killing

Defect in NADPH

20

Maturation process of T cells. where they from and where do they go?

T cells are made in the bone marrow and mature in the thymus

21

Which T cells recognize which MHC class

CD4 t cells recognize MHC class 2CD8 t cells recognize MHC class 1

22

CD4+ T cell activation requires what?(2 signals involved in activation)And what is their role

Antigen presenting cells (APCs) phagocytize antigen, process it, then present it on its MHC 2 membrane//B7 (on APC) binds to CD28 on MHC2CD4 release cytokines to help in inflammation

23

What do CD4 helper T cells do?

They help both CD8+ / BcellsBroken into 2 subsetsTh1 helps CD8Th2 helps with B cells

24

Th1 helps what cells and how?

Th1 helps CD8 cellsby releasing IL-2 (t cell growth factor and activator) and IFN-g (macrophages)

25

Th2 helps what cell and how

B cellsIL-4 (class switching to gig and igE)IL-5 (Eosinophil chemotaxis and activation/maturation of B cells)

26

Whats a main enzyme that triggers apoptosis

caspase

27

B Lymphocyte maturation process

immature B cells are made in the bone marrowUndergo ig rearrangement to become naive B cells that express surface antigens IgM and IgD

28

B cell activation requires 2 signals

B cell presents antigen to CD4 via MHC 2CD40 receptor (on Bcell) binds to CD40L on b cell

29

Marker for hematopoietic stem cell (in bone marrow)

Cd34

30

Stem cell of the lung

Type 2 pneumocytes

31

When converting type 3 collagen to type 1 collagen , which enzyme is used and what does it require as a cofactor

Collagenase

Zinc

32

3 things to think about when you see an enlarged lymph node

Metastatic cancer

Reactive hyperplasia (acute infection)

Lymphoma 

33

Tumor cell neoplasia is (monoclonal or polyclonal)

monoclonal

34