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Flashcards in Pathoma Deck (381):
1

What CD receptor do neutrophils express

CD14

2

What role does PGI have

PGI = Platelet gathering inhibitor

3

What role do Mast Cells have

Release Histamine Vasodilation and increase vascular permeability

4

What is the second phase response of Mast Cells

Recruit Leukotrienes

5

4 Mediators that call in Neutrophils

LTB4, C5A, IL-8, bacteria products

6

Classical compliment system

(ig) GM makes Classic cars (C1)

7

Pathway/end result of compliment system

C3, C5, generation of membrane attack complex (MAC)

8

What components of compliment system trigger mast cell degranulation

C3a and C5a

9

one role of C5 in the compliment system

Calls in neutrophils

10

What does bradykinin do?

Same thing as histamine increase vasodilation, vascular permeability (++pain)

11

Prostaglandin E2

E2 fEEEEEver and pain

12

mediators that macrophages release

TNF-g, IL-1 Stimulate cox for PGE2 for fever

13

Leukocyte migration and rolling what are the binding factors

E-selectin, P-selectin Binds the Sialyl-Lewis

14

Leukocyte adhesion of vessel wall

ICAM (intercellular adhesion molecule)

15

Delayed separation of umbilical cord

Leukocyte adhesion deficiency (LAD) CD18

16

Lack of pus formation

Leukocyte adhesion Deficiency

17

Impaired phagolysosome formation

Chediak-Higashi

18

Whats the mechanism of O2 to HOCl (bleach) in a phagocyte degredation

O2 --> O2- --> H2O2 --> HOCL

19

What is the defect in Chronic Granuloma Dz (CGD) aka poor O2 dependent killing

Defect in NADPH

20

Maturation process of T cells. where they from and where do they go?

T cells are made in the bone marrow and mature in the thymus

21

Which T cells recognize which MHC class

CD4 t cells recognize MHC class 2 CD8 t cells recognize MHC class 1

22

CD4+ T cell activation requires what? (2 signals involved in activation) And what is their role

Antigen presenting cells (APCs) phagocytize antigen, process it, then present it on its MHC 2 membrane//B7 (on APC) binds to CD28 on MHC2 CD4 release cytokines to help in inflammation

23

What do CD4 helper T cells do?

They help both CD8+ / Bcells Broken into 2 subsets Th1 helps CD8 Th2 helps with B cells

24

Th1 helps what cells and how?

Th1 helps CD8 cells by releasing IL-2 (t cell growth factor and activator) and IFN-g (macrophages)

25

Th2 helps what cell and how

B cells IL-4 (class switching to gig and igE) IL-5 (Eosinophil chemotaxis and activation/maturation of B cells)

26

Whats a main enzyme that triggers apoptosis

caspase

27

B Lymphocyte maturation process

immature B cells are made in the bone marrow Undergo ig rearrangement to become naive B cells that express surface antigens IgM and IgD

28

B cell activation requires 2 signals

B cell presents antigen to CD4 via MHC 2 CD40 receptor (on Bcell) binds to CD40L on b cell

29

Marker for hematopoietic stem cell (in bone marrow)

Cd34

30

Stem cell of the lung

Type 2 pneumocytes

31

When converting type 3 collagen to type 1 collagen , which enzyme is used and what does it require as a cofactor

Collagenase Zinc

32

Tumor cell neoplasia is (monoclonal or polyclonal)

Monoclonal

33

3 things to think about when you see an enlarged lymph node

Metastatic cancer Reactive hyperplasia (simple infection) Lymphoma

34

What is a main cause of neuronal tube defects

folate deficiency

35

Anencephaly is associated with what involving the amniotic fluid

Polyhydramnios - too much amniotic fluid because the baby doesn't have a developed brain to swallow it

36

Whats syringomyelia? and what brain malformation is associated with it

Degeneration of the spinal cord "CAPE/SHAWL-like" bilateral loss of pain and temp in upper extremities usually associated with Chiari malformation

37

Whats chiari malformation

herniation of the vermis through the foramen magnum

38

What is ALS (Amyotrophic Lateral Sclerosis)

Degenerative disorder of the upper and lower motor neurons (corticospinal tract) zinc copper superoxide dismutase mutation (SOD- removes free radicals)

39

Fredrick Ataxia

Degenerative disorder of the cerebellum Fred the FRAT star - mess up of Frataxin (iron binding protein) staggering and falling but has a sweet big heart diabets and hypertrophy cardiomyopathy GAA

40

What is the classic triad of meningitis

Stiff neck, headache, fever

41

How do you differentiate the etiology of meningitis when looking at the CSF via lumbar puncture

Bacterial- neutrophils with low CSF glucose Viral- lymphocytes with normal CSF glucose Fungal- lymphocytes with low CSF glucose

42

What happens in an epidural hematoma and what should you see on CT

fracture of the skull that severs the middle meningeal artery Lens shaped lesion on Ct

43

What happens in a subdural hematoma What should you see on CT

Rupture of the bridging veins Blood BENEATH the dura crescent shape

44

What is the key cell that myelinated axons in the CNS

Oligodendrocyte

45

What is the key cell that myelinated axons in the PNS

Schwann cell

46

What is multiple sclerosis

Autoimmune destruction of CNS myelin and oligodendrocytes HLA-DR2 SIIIN Scanning speech, intention tremor, incontinence, INO, Nystagmus

47

What is a lacunar stroke and which vessels do they most commonly involve

infarcts in the deep areas of the brain. Mostly in the lenticulostriate vessels off the MCA

48

Where does intracrebral hemorrhage mostly occur and why

in the basal ganglia due to the lenticulostriate vessels rupturing (micro aneurysms)

49

Worst headache of life

Subarachnoid hemorrhage usually rupture of saccular (berry) aneurysm usually located in the anterior circle of willis (ACA) Bloody or yellow CSF with tap Only blood at the bottom of the brain

50

What is Central pontine myelinolysis and how do you get it what is the major presenting case

Focal demyelination of the pons Caused by RAPID iv correction of Hyponatremia (from low to high the pons will die) Presents as Locked in syndrome- acute paralysis-

51

In GREY MATTER Degenerate neurons in the cortex? Degenerate neurons in the basal ganglia (deeper structure of the brain)?

Dementia Basal ganglia is required for movement so movement problems

52

Whats the most common disease for dementia? What is it? and grossly brain findings

Alzheimer's dz (degeneration of the GREY matter in the cortex) Slow onset memory loss, disorientation, loss of learned motor skills Diffuse Brain atrophy, narrowing of Gyri/widening of sulk Neuritic plaques (amyloid precursor protein APP with ab amyloid) Neurofibrillary tangles (hyperphosphorylated tau protein)

53

What are risk factors for Alzheimer's dz?

Deficient Ach ApoE2 (decreases risk) ApoE4 (increases risk) Presenillin -1/2 Neuritic plaques Amyloid precursor protein mess up that causes AB amyloid

54

What are neurofibrillary tangles, and in which dz are they seen?

Hyperphosphorylated Tau protein seen in Alzheimers Dz

55

Vascular Dementia

Dementia in elderly due to multiple infarcts of chronic ischemia

56

Pick'z DZ (Frontotemporal Dementia) it "picks" the frontotemporal

Frontal (behavioral) and Temporal (language) dementia Pick Bodies, ROUND Hyperphosphorylated tau

57

What is parkinson dz What are the clinical presentations (hint: its a a trap

Degenerative disorder of CNS involving dopamine deficiency neurons in the Substantia viagra Associated with Lewy Body (alpha-synuclein) Tremor (pill rolling) Rigidity (Cogwheel) Akinesia (brady) Posture (instability shuffle gait)

58

What are lewy bodies composed of? What disorder would you find these

composed of alpha-synuclein found in Parkinson Dz

59

Difference between lewy body dementia and Parkinson Dz

Lewybody dementia has early onset (parkinson takes a while) cortical lewy body= Ha'lew'cinations

60

What is the degeneration of gabarnergic (inhibitory) neurons in the brain? Where in the brain is the mess up? Whats the trinucleotide repeat

Huningtons Dz Caudate nucleus GABAnergic (inhibitory) neurons are destroyed CAG (has anticipation so it gets worse with each generation) CAG (C)audate loses (A)ch and (G)aba

61

What is the striatum and what composes it

Striatum is the basal ganglia which is important in movement. The caudate and the putamen makes it

62

What is Hydrocephalus and what TRIAD does it present? (wet whack and wobbly) and what usually improves it

Increased CSF resulting in dilated ventricles Urinary incontinence, dementia, gat instability (magnetic feet) Lumbar puncture (LP) relieves pressure

63

With hydrocephalus you should be thinking the stretching of the _______

corona radiata

64

Spongiform Encephalopathy

Degenerative dz of prion protein most common form is CJD

65

Creutzfield Jakob dz (CJD)

spongiform encephalopathy rapid dementia Ataxias and startle myoclonus

66

What is the role of the astrocytes?

Forms the blood brain barrier

67

What are the tumors that arise from astrocytes? kids/adult

Kids: Pilocytic Astrocytoma Adults: Glioblastoma Multiforme

68

What is the role of Oligodendrocytes?

Myelinate axons in the CNS

69

What are the tumors that arise from oligodendrocytes? Kids/adults

Kids: n/a Adults: oligodendroglioma

70

What is a glioblastoma multiforme? where does it arise

Malignant tumor of the astrocytes in brain Most common malignant CNS tumor in adults Crosses the Corpus callosum- buffterly glioblastoma Psuedopallisading GFAP

71

What is a meningioma what does it look like on histo?

Benign tumor of the arachnoid cells? Most common benign tumor "Whorl cells"

72

What is a Schwanomma? which cell type does it arise? What section of brain does it involve /histo

benign tumor of Schwann cells in the PNS Usually located at the cerebellar pontine angle (CPA) and messes with the Cranial Nerve CN8 s100+

73

Oligodendrogliomas / what cell it arises from / what section of the brain does it involve / histo

Arise from the oligodendrocytes in the white matter (bc they mylelinate-white) fucks with the frontal lobe fried egg appearance calcified tumor

74

What is the most common CNS Tumor in children and where does it arise (Remember that most kid CNS tumors are below the tentorium)

Pilocytic Astrocytoma Cerebellum Rosenthal fibers GFAP

75

Medulloblastoma /histo

CNS tumor in kids Neruoectodermal Tumor Former wright rosettes small blue cells

76

Which cells line the ventricular space in the brain

ependymal cells

77

ependymoma

Malignancy of the ependymal cells commonly arises in 4th ventricle hydrocephalus?

78

Craniopharygioma

tumor that arises from the remnants of the Rathe's pouch (pituitary) compression of optic chiasm Bitemporal hemianopsia

79

What is Bitermporal Hemianopsia and what causes it

Compression of the optic chiasm that leads to loss of lateral vision

80

What is the most common form of vasculitis and who does it usually effect? what are some symptoms? Tx?

Temporal (giant cell) arteritis Granulomatous Vasculitis Older women Headache (temporal), visual disturbances (ophthalmic), jaw claudication Tx-corticosteroids

81

Takayasu Arteritis

Same as temporal arteritis (granulomatous vasculitis) But its usually in younger asain females (less than 40) "pulseless dz" Tx=corticosteroids

82

Polyarteritis Nodosa

Necrotizing vasculitis, involving most organs except the lungs usually a Serum Hep. B surface antigen String of pearls

83

Kawasaki Dz. What is it and who does it affect, and which artery does it mainly fuck up? How do you treat it

Vasculitis affecting asain children less than 4 yrs old. CRASH and Burn Conjunctival injection, Rash, Adenopathy, Strawberry tongue, Hand (foot) edema and fever Coronary Artery IV immunoglobulin and ASPIRIN

84

Buergers DZ what is it/ the main cause? and whats the clinical finding

Medium vessel vasculitis Caused by heavy smoking Autoamputation of digits

85

Wegener Granulomatosis We'C'ener Whats the tx

Small vessel vasculitis involves the C's Nasopharynx/lungs/kidney Triad -necrotizing vasculitis, necrotizing granuloma in the lung/upper airway, necrotizing glomerulonephritis C-ANCA tx- Cyclophosphamide

86

Microscopic Polyangiitis? which organ does it affect? similar to which other small vessel vasculitis except for? how do you treat it?

Small vessel vasculitis affects lung and kidney no granulomas and no nasopharyngeal involvement Tx-Cyclophosphamide P-ANCA

87

Churg-Strauss? Which organ does it affect? Which small vasculitis is it similar to? how do they differ?

Small vessel vasculitis Necrotizing granulomatous vascuilits w/ eosinophils involves lungs and heart Similar to microscopic polyangiitis (Both have p-ANCA but differ bc it has granulomas and ASTHMA and no peripheral eosinophilia)

88

HSP (Henoch Schönlein Purpura)? what population is most common? whats the clinical presentation what infection does it usually follow

Small vessel vasculitis due to IgA immune complex deposition (IgA nephropathy) most common in children Palpable purpura on BUTT/LEGS Follows Upper Respiratory Infection

89

What is the defined limits of Hypertension and risk factors

BP >140/90 age,race, obesity, high salt diet

90

What is atherosclerosis? which size vessels does it effect? what are the 4 main arteries it hits (in order of occurrence) how much occlusion do you need to have symptoms

A buildup of cholesterol plaque in medium/large muscular arteries Abdominal Aorta > coronary a.> popliteal A. > carotid greater than 70%

91

What is the progression of Atherosclerosis

1. endothelial cell fuck up 2. macrophage and LDL accumulation 3.Foam cell formation 4. Fatty streaks 5. Fibrous plaque

92

What are the two types of ArteriOLOsclerosis

Hyaline:Vascular thickening of vessel wall with protein caused by Hypertension and diabetes Hyperplastic: Onion Skinning caused by sever HTN

93

What causes Hyaline ArteriOLOsclerosis What does it lead to?

HTN and Diabetes HTN increased BP forces protein into the vessel wall Diabetes- Causes vessel wall to be leaky so protein leaks in leads to ischemia and glomerular scarring

94

What causes Hyperplastic AteriOLOsclerosis

Thickening of vessel wall due to hyperplasia of smooth muscle due to malignant HTN

95

Where do you see fibrinoid necrosis (beads on string)

Malignant HTN

96

Whats an Aortic Dissection What disorders are prone for Dissections Most common Cause of death

When a rip in the INTIMA of a vessel causes blood to penetrate and create a lumen between intima and media Literally rips through and dissects the two layers due to Pre-existing weakens of the media (HTN) Connective tissue disorders (Marfan Syndrome) Cardiac tamponade

97

Thoracic Aneurysm What dz most commonly leads to it whats the most common clinical presentatoin

Balloon like dilation of the aorta. must have weakness in the wall Tertiary syphilis - caused by endarteritis of vaso casorum (prevents nutrients to the wall of vessels so it atrophies) Pulsatile abdominal mass

98

Chest pain that arises with exertion or stress is ____ What dz commonly leads to it Whats the most common presentatoin

Stable angina

atherosclerosis- not enough blood getting to the heart so it becomes hypoxic/ischemic

Chest pain that radiates to left arm or jaw -St depression Tx- rest or Nitroglycerin

99

Chest pain that occurs at rest is ____ What causes it? Tx?

Unstable angina Rupture of atherosclerotic plaque with thrombosis and incomplete occlusion of the coronary artery -Nitroglycerin high risk of MI

100

Vasospasm of the coronary artery? Tx

Prinzmetal angina tx-CCB's or Nitrates

101

Difference between myocardial infarct (MI) and unstable angina

MI has Thrombosis of a Plaque with COMPLE occlusion. also has IRREVERSIBLE damage to myocytes

102

Which chamber of the Heart does MI mostly occur? Which coronary artery usually gets occluded

LEFT VENTRICLE 1-Left anterior descending (LAD) anterior wall and atrial septum necrosis 2. Right coronary artery-poserior wall of heart

103

ST elevation MI (STEMI) What type of infarct thickness?

Transmural Full thickness

104

non ST elevation MI (NSTEMI) thickness?

subendocardial infarcts

105

Which enzymes are indicative of an MI

TROPONIN rises at 2-4hrs peaks at 24 hrs elevated for a week CK-MB rises and goes down quickly can be used to determine multiple infarcts

106

Which cardiac enzyme is used to determine multiple infarcts

CK-MB because it rises and galls quicker than TROPONIN

107

Tx for Myocardial infarction

Aspirin/Heparin (to prevent further clotting) Supp. O2 Nitroglycerin Beta Blockers

108

What is the progression of an MI (days weeks months)

1 day / 1 week / 1 month coagulative necrosis (dead cells) / Neutrophils and macrophages / granulation tissue and scar

109

Type of pericarditis that occurs 6 weeks after an infarct due to autoantibodies against the pericardium

Dresslers Syndrome

110

Whats congestive heart failure mainstay treatment?

When the heart fails to pump appropriately (usually backs into the lungs) Tx-ace inhibitors

111

Hemosiderin-laden macrophages

Heart failure cells found in lungs with pulmonary edema

112

Whats the most common congenital heart defect and what syndrome is it associated with

Ventricular septal defect (VSD) associated with FETAL ALCOHOL SYNDROME

113

What is the mnemonic for left to right shunt yes right to left?

(R)ight to (L)eft shunts are eaRLy cyanosis (L)eft to (R)ight occur LateR cyanosis

114

What is atrial septum defect? what defect causes this

defect in the septum between atriums Osmium secundum defects

115

Holocystolic machine like murmur cyanosis of lower extremities How do you treat this What disorder is it associated with

Patent ductus arteriousus PDA failure of ductus arterioles to close cyanosis of lower extremities Tx-ENDomethacin ends PDA Congenital rubella

116

Tetralogy of Fallot

R-->L shunt most common cause of eaRLy cyanosis (fixed with squatting) Pulmonary stenosis Boot shaped heart (hypertrophy) Overriding aorta/VSD

117

Transposition of the Great vessels? What dz is it associated with

Failure of the aorticopulmonary system to spiral (they swap places) Maternal diabets

118

What is rheumatic fever? What is it usually caused by?

occurs 2-3 weeks after strep throat (alpha-beta hemolytic streptococci) M- protein JONES criteria which is joints, heart problems, nodules, erythema marginatum, s-chorea arthritis, pan(all layers)carditis (mitral valve), subQ nodules, rash, rapid movement

119

Jones criteria whats it used to diagnosis

joints, heart problems, nodules, erythema marginatum, s-chorea arthritis, myocarditis (mitral valve), subQ nodules, rash, rapid movement

120

Aortic Valve Stenosis how do you get it? What cardiopathy and other symptoms does it lead to?

Narrowing of the aortic valve Systolic ejection click followed by crescendo- decrescendo murmur "wear and tear of valve" -presents in late adult hood or when you have a bicuspid valve instead of (tri) leads to Left ventricular hypertrophy SAD Scope, Angina, and Dyspnea on exertion

121

Aortic Regurgitation why does it happen?

"blowing murmur" Back flow of blood from aorta into LV during diastole Aortic root DILATION or valve problems Hyperdynamic circulation (bounding pulse, pulsating nail bed, head bobbing)

122

What is hyper dynamic circulation and what causes it?

Seen in aortic regurgitation Bounding pulse, pulsating nail bed, head bobbing the regurg increases the volume of the next stroke in LV so it keeps adding and adding pressure

123

Mitral valve prolapse

ballooning of the mitral valve into left atrium during systole Myxoid degeneration of the valve (floppy) *mid systolic click* like a parachute

124

Mitral Stenosis what happens to the atrium

Narrowing of the mitral valve, usually due to rheumatic valve dz Opening snap followed by a rumble LA overload- pulmonary congestion (edema)

125

Which organism causes Endocarditis (low virulence)

S viridians most common cause of endocarditis, infects previously damaged valves results in small vegetations that don't destroy valves

126

Which organism is the most common cause of (acute) Endocarditis in IV drug users and which valve is involved

S. Aureus (acute) Large vegetations on normal valves Most commonly Tricuspid

127

Which organism causes Endocarditis of prosthetic valves?

S. Epidermidis

128

Which organism causes Endocarditis with underlying colorectal cancer

S. Bovis

129

Endocarditis with Negative Blood cultures

HACEK Haemophilus, actinobacilus(aggregatibacter, Cardiobacterium, Eikenella, Kingella)

130

Clinical features of endocarditis

Fever, murmur, Janeway lesions(painless on palm or sole), Osler (ouch) nodes (painful on fingers or toes)

131

endocarditis with nodules on both sides of the valve And what is it associated with

Libman-Sacks Endocarditis SLE mitral valve

132

Dilated Cardiomyopathy (most common cardiomyopathy) What causes it tx-

Dilation of all 4 chambers systolic dysfunction (dilated so it can't contract properly), valve regurgitation ABCCCD + p alcohol abuse, Beri beri, COXSACKE, cocaine use, Chagas, Doxorubicin toxicity and pregnancy Transplant

133

Hypertrophic Cardiomyopathy whats a huge problem with this

Hypertrophy of left ventricle commonly due to genetic mutations in Sarcomere protein Decreased cardiac output due to the heart being so tight. (it can't dilate to get blood in) Can lead to SUDDEN DEATH due to ventricular arrhythmia myofibrillar disarray

134

Restrictive cardiomyopathy what are the causes

Decreased compliance of ventricles (won't dilate so you have a diastolic problems sarcoidosis, fibrosis, endocardial fibroelastosis (thick fibroelastic tissue in endocardium of young children), hematochromatosis LOFFLER SYNDROME- endomyocardial fibrosis with a prominent eosinophilic infiltrate

135

Loffler syndrome and does it lead to

endomyocardial fibrosis with a prominent eosinophilic infiltrate leads to restrictive cardiomyopathy

136

Myxomas were does it usually occur (which valve)

Most common primary cardiac tumor in ADULTS Usually occurs in the left atrium and causes syncope described as "Ball valve" obstruction

137

Rhabdomyoma

most common primary cardiac tumor in CHILDREN associated with tuberous sclerosis

138

what is primary hemostasis

injury to a blood vessel that results in a PLATELET PLUG (stabilized by secondary hemostasis)

139

What is secondary hemostasis

Stabilization of the platelet plug via coagulation cascade

140

Steps of thrombogenisis

1)Endothelial damage= vasoconstriction 2)Exposure: vWF is exposed to collagen and binds 3)Adhesion: Platelets bind to vWF via Gp1b (conformational change) platelets release ADP and Thromboxane 4a)ADP helps platelets adhere to endothelium via increased Gp2b/3a receptors 4b)platelet aggregation via FIBRINOGEN between Gp2b/3a receptors

141

Where does vWF come from?

Weibel-palade bodies of the endothelial cells and Alpha-granules of platelets

142

Clinical signs of Primary hemostasis fuck up

Mucosal and skin bleeding (nose -EPISTAXIS-, gi, menstrual)) bruising, petechia, purpura

143

Idiopathic Thrombocytopenia Purpura (ITP) what clinical values will you see Tx?

Autoimmune production of IgG antibodies against platelet antigens low platelet count, increased megakaryocytic tx-corticosteroids, ivig (the spleen produces the antibodies and also destroys them. so ivig will distract the spleen to give the bodys platelets a chance to recover), splenectomy

144

Microangiopathic hemolytic anemia

Small blood vessels get a platelet thrombus that shears any passing RBCs Shcistocytes (helmet cells)

145

Thrombotic thrombocytopenia purpura (TTP) tx=

platelet aggregation that leads to thrombocytopenia (purport from lack of platelets) Deficiency of ADAMTS13 (which breaks down vWF) so you have to much vWF which leads to increased platelet aggregation tx-plasmapharesis, steroids

146

Hemolytic-uremic syndrome

Thrombocytopenia, microangiopathic hemolytic anemia, and acute renal failure seen in children after Etec infection caused by Shiga like toxin

147

Bernard-Soulier syndrome? whats the defect in?

a defect in platelet plug formation due to decrease in Gp1b defect in platelet-to-vWF adhesion increase bleeding time

148

Glanzmann Thrombasthenia

genetic deficiency in Gp2b/3a platelet aggregation is impaired ( G2pb/3a is what connects platelet to platelet via fibrinogen

149

vWF disease tx-

deficient in vWF tx- desmopressin

150

Vit. K deficiencey

Decrease in synthesis of factors 2,7,9,10,C,S 7 having the shortest half-life

151

Warfarin

inhibits vit K synthesis via inhabiting epoxide reductase

152

Heparin induced Thrombocytopenia (HIT)

when you develop IgG antibodies against Heparin-bound platelet factor 4 (PF4) the antibodies activate platelets--> thrombosis and thrombocytopenia elsewhere

153

Disseminated inter vascular coagulation (DIC) whats the best screening test?

Secondary to other dz pathologic activation of coagulation cascade widespread micro thrombi that leads to ischemia and infarction Consumption of all these platelets leads to bleeding everywhere else (especially IV and mucosal sites) test- Elevated D dimers (when you split fibrin it produces D dimers)

154

What blocks activation of plasminogen

Aminocaproic acid

155

What two characteristics would you see in a thrombosis

Lines of zahn attachment to vessel wall

156

Vitamin B12 or folate deficiency leads to elevated ________

homocysteine levels

157

TetrahydroFOLATE to methionine

THF--> gives off methyl to Vit. B12---> gives methyl to Homocysteine ----> methionine

158

Whats the role of Protein C or S

Inactivate factors V and VIII in coag cascade

159

whats the deal with factor V leiden

Resistant to degradation/inactivation by Protein C

160

Whats are the anemia subtypes (based off of MCV) mean corpuscular volume (size of red blood cell)

Microcytic MCV 100

161

Role of ferroportin Role of Transferrin Role of Ferritin

Transfers iron into the blood Delivers iron to liver and bone marrow macrophages Iron Storage

162

Why do you get anemia of chronic dz?

With chronic dz, you get prolonged inflammation. and in order to stop whatever is causing the sickness, the body increases hepcidin (which fucks up ferroportin and prevents release of iron from ferritin ) which decreases iron transport ----> iron deficiency ---> anemia ferritin goes up/ TIBC goes down Serum iron goes down

163

What does hepcidin do

Prevents release of iron from storage sites to deprive any infection of iron and kill it off

164

Sideroblastic anemia

 

what are some of the causes

Tx?

Defect in protoporphyrin synthesis --> defect in Hb. due to X-linked defect in ALA synthase

 

defect in protoporphyrin leads to iron getting trapped in mitochondria of erythroblasts

 

congenitcal (ALA synthase), lead poisoning, alcoholism, or B6 Deficiency (pyridoxine)

tx-B6 pyridoxine

165

what attaches Protoporphyrin to Iron (to make heme)

where does this happen

Ferrochelatase

in mitochondria 

166

Ringed sideroblasts

when protoporhyin synthesis is messed up so iron gets loaded into mitochondria.

This iron has nothing to bind to so its trapped there. These iron-laden mitochondrias form rings around the nucleus

167

Thalassemia 

Decrease in synthesis of Globulin chains

(leads to microctyic anemia)

168

alpha Thalassemia

4 allele deletion

3 allele deletion

2 and 1 allele deletion

 

Normally you have 4 alpha alleles 

Defect in A-globin deletion

4 allele-no alpha globin, excess gamma globin, (makes gamma4 -Hb BartsHydrops fetalis

3 allele- very little alpha globin, Excess ß-globin (HbH)

2/1 not clinicilaly severe

 

169

whats the significance of cis vs trans deletions in alpha-thalassemia

cis is when 2 alpha alleles are knocked out on the same chromosome. this can lead to to severe thalasemia in offspring (Prevalent in Asains) 

Trans isnt that bad (African population)

170

ß-Thalassemia (2 beta genes) 

Minor (ß/ß+) (normal/diminished)

Major (ß°/ß°) both B are wiped out

Gene mutation

minor-asymptomatic with Increase in HbA2

major

 Absent Beta chain, target cells,

massive erythroid hyperplasia- expansion of hematopoiesis into marrow of Skull and facial bones (crew cut and chipmunk like face)

extramedulary hematopoiesis- liver and spleen starts to make it (hepatosplenomegaly)

Risk of Parvovirus  B19- aplastic crisis

2° hemochromatosis

 

171

Macrocytic Anemia

(Megaloblastic anemia)

MCV? what deficiencies cause it? why do the deficiencies lead to it

MCV>100

Folate or Vit. B12 deficiency 

(1 less division so theyre macro) due to mess up of DNA precursors 

Hypersegmented Neutrophils

172

whats the role of folate and Vit B12 in synthesis of DNA (flow chart)

Tetrahydrofolate has a methyl and in order for it to make DNA it has to give that methyl to Vit. B 12

Vit B12 then gives that methyl to Homocystiene. 

Homocystiene + methyl = Methionine 

173

Folate

Where is folate absorbed?

what casuses its deficiency

Clinical findings of deficiency

Lab findings

-In the Jejunum

-Poor Diet (alcoholics,elderly), Increased demand (preggos, cancer, hemolytic anemia), Drugs methotrexate

-Megaloblastic anemia (macrocytic RBCs, Hypersegmented Neutrophils), Glossitis 

-Decreased serum folate(duh), 

Increased Homocysteine( piles up because folate doesnt pass Methyl to vit.b12 -->so vit b12 cant change homocysteine to methionine

Methylmalonic acid is Normal

174

Vit. B12 (Cobalamin)

How is it absorbed/where

What causes its deficiency (alot)

Clinical and lab findings

 

First needs to be cleaved by pancreatic enzymes

Then, it binds to Intrinsic Factor (IF) to be absorbed in the Ileum. Large hepatic stores so it takes a long time to develop deficiency. 

-caused by insufficient uptake (Vegan), malabsorption (Crohn dz), Pernicious anemia (Autoimmune destruction of parietal cells- cant make IF)

Diphyllobothrium Latum (fish tapeworm) 

-Macrocytic anemia with Hypersegmented neutrophils, Glossitis

-Subacute Combined Degeneration of Spinal Cord -B12 converts methylmalonic acid --> Succinyl Coa. so without B12 you get a shit tone of mma which is toxic to myelin

175

Pernicious Anemia

Autoimmune destruction of Parietal cells. 

This leads to a deficiency of Intrinsic Factor (IF)

Which means you cant absorb Vit B12

176

What are the 2 major processes that Vit B12 are invovled in?

-In the synthesis of DNA, by accepting methyl from Tetrahydrofolate, then giving it to Homocysteine 

-Converts Methylmalonic acid ----> Succinyl CoA myelin synthesis

too much methylmalonic acid is toxic to myelin

 

177

Normocytic Anemia

MCV?

what does the reticulocyte count look like?

 

-MCV 80-100

-Increased reticulocyte count/percentage (falsely elevated) due to destruction of RBCs

You must correct it tho. 

178

In normocytic anemia, what are the perameters for when you correct the reticulocyte count? 

Whats the equation

>3% indicates good response by bone marrow; suggests peripheral destruction

<3% indicates bad response by bone marrow; suggests underprodcution

Reticulocyte count x (Hematocrit/45)

in the example it would be a bone marrow problem

179

Extravascular hemolysis 

Which Anemia does it cause

What are clinical findings

-Normocytic anemia

-Extravascular destuction occurs from macrophages in spleen 

-Anemia with Splenomegaly, Jaundice due to unconjugated bilirubin (increased risk for gallstones), marrow hyperplasia with corrected reticulocount >3%

 

remember that when hemoglobin is broken down, the protoporhyrin of heme gets turned into Unconjugated billirubin

180

Intravascular Hemolysis

What type of anemia does it cause

lab findings

-Normocytic Anemia

-Destruction of Hemoglobin in the blood vessel. Haptoglobin (binds to free Hb and brings it back to spleen)

Hemoglobinemia, Hemoglobinuria, Hemosiderinuria

181

Haptoglobin

Binds free hemoglobin (Hb) and brings it back to spleen.

levels of haptoglobin are decreased in intravascular hemolysis bc they get used up

182

Hereditary Spherocytosis

clinical findings

how is it diagnosed

tx?

Extravascular hemolysis due to defect in RBC membrane (ankyrin, band 3, spectrin are protein fuckups)

Small round RBC with no central pallor (premature removal by spleen) 

Increased MCHC (mean corpuscular hemoglobin concentration) only dz with this

-Splenomegaly, Aplastic crisis (ParvoVirus B19 infection)

-osmotic fragility test

-Splenectomy

 

183

Sickle Cell Anemia

whats the mutation?

what causes the sickling

What protects against the sickling (tx)

clinical findings

Auto Recesive mutation in the ß gene (glutamic acid with valine)

-Stressors such as Low O2, high altitude, acidosis, dehydration

-HbF(fetal), give hydroxyurea to increase HbF

'-Aplastic crisis (parvovirus B19),

Painful crisis: dactylitis (sausage fingers), acute chest syndrome, avascular necrosis

Autosplenectomy (howell jolly bodies)- due to infarct of the spleen. increases risk of infection S. pneumonia

Salmonella osteomylitis

184

Hemoglobin C

whats the mutation

Auto Recessive mutation in ß Chain

Glutamic acid is replaced by Lysine

185

Paroxysmal nocturnal hemoglobinuria (PNH)

why does it happen?

lab findings

what does it lead to

Tx

aquired dsyfunciton of GPI via hematopoietic stem cell

(anchors decay-accelerating factor -DAF CD55- that protects RBC from complement activation) 

at night we breath slower leading to respiratory acidosis --> activation of compliment (intravascular hemolysis) which will fuck up these RBCs since theyre predisposed already 

-hemoglobinemia, hemoglobinuria

-leads hemolytic anemia (duh), pancytopenia, thrombosis

10% of pts develops AML

-tx eculizumab (compliment inactivator)

 

 

 

 

 

186

G6PD deficiency

whats its function

what causes oxidative stres

what cells does this produce?

Clinical signs

X-linked Recessive d.o -->reduced half life of G6PD

(increases RBCs succeptible to oxidative stress)

G6PD helps create NADPH. NADPH helps produce glutathione which protects against oxidative stress

-Infections, Fava Beans

Heinz bodies & Bite cells

Back Pain from all the released Hb(nephrotoxic)

 

187

Immune hemolytic Anemia

What are the different types 

what are they associated with

Warm IgG: EXTRAVASCULAR chronic anemia due to IgG binding to RBC and removing membrane (results in spherocytes). Associated with SLE and CLL (Methyldopa)  / (Warm weather is GREAT) 

Cold IgM: Acute anemia triggered by cold. Associated with CLL, Mycoplasma pneumonia, Infectious Myonucleosis. (Cold weather is MMMiserable)

 

188

What is the Coombs test?

Direct. vs indirect

direct- do i have cells already bound by IgG? you give them anti- IgG. so if the answer is yes, the RBCs wil agglutinate and percepitate

Indirect- Does the pt have antibodies in their serum? normal RBCs added to patients serum. if serum has the antibodies, the RBCs agglutinate when Coombs is added

 

189

Whats the CD for hematopoeitic stem cells?

Give the lineage of everything that it can produce

CD34

190

What are some causes of Neutropenia

Sepsis/severe infection

Drugs (chemotherapy)

191

What are causes of Lymphopenia

Immunodeficiency: HIV, SCID, SLE, sepsis

High levels of cortisol (or corticosteroids)-these cause apoptosis

Radiation (lmyphocytes die quickest)

192

Whats the anatomy of lymph node

What areas are the B and T cells located

 

B cells are in the cortex (follicles)

T cells are the in the Paracortex (swells with viral infection)

193

What are the markers for Lymphoblasts in the blood?

Myeloblasts?

TdT+ (marker of pre T and pre B)

CD10,19, 20 (marker of pre B)

_______________________

myeloperoxidase(+)

Auer Rod

 

194

Tell me about ALL (acute lymphoblastic Leukemia)

whats the good translocation

Most frequently in childeren

Highly associated with Down syndrome (after age of 5)

T(12;21) has good prognosis

Subdivided into T-ALL and B-ALL

**acute is always immature

195

T-ALL what physical finding should give it away 

T should make you think of Thymic (Mediastinal mass)

196

AML (Acute Myeloblastic leukemia)

whats the classic translocation (also known as APL-acute promyelocytic leukemia). and what does this trans do?

what systemic problem can AML lead to? and how do you treat it?

Myeloperoxidase (+) ->these aggregate to form Auer Rods 

APL- T(15;17) fucks up the retinoic acid receptor ->the cells cant mature

can lead to DIC (treat with ATRA-causes blasts to mature)

197

under AML, if the leukemia is specifically monocytes, what should you think of

speciffically megakaryocytes

lack Myeloperoxidase//heavily infiltrates the Gums

Associated with Downs syndrome before 5

198

whats the deal with CLL

who does it affect, what are the cell markers

what type of cells will histo show 

what can CLL transform into?

Usually in older adults

proliferation of naive B cells (CD5,20)

smudge cell

Diffuse Large B-cell Lymphoma (DLBCL) 

199

Hairy Cell Leukemia 

what does it stain positive for?

clinical features

proliferation of Mature B-cells

hairy/fuzzy cells

stains positive for TRAp

massive Splenomegaly (red pulp) / dry tap on bone marrow aspiration

200

CML (chronic myelogenous leukemia)

whats the translocation

how do you treat it

what can it transform to?

increase of mature granulocyte (mostly basophils) LAP (-)

Philadelphia chromosome t(9;22)

BCR-ABL (increases tyrosine kinase activity)

To treat, you gotta inhibit tyrosine kinase - Imatinib

can transform into Acute Leukemia 

201

Polycythemia Vera

what is messed up(mutation) that causes it

clinical symptoms

Treatment?

proliferation of mature myeloid cells (especially RBCs) EPO is decreased

JAK2 kinase mutaiton

-blurry vision, Increased risk of thrombosis (Budd chiari), flushed face, itching after bathing (mast cells release histamine)

tx-phlebotomy (get rid of some of that blood)

2nd tx is hydroxyurea

202

2° Polycythemia (reactive)

Increased EPO from either lung dz (low O2)

or Tumor that produces EPO (renal cell carcinoma)

203

Essential Thrombocythemia

proliferative disorder of myeloids (specifically Platelets)

shit ton of platelets - either bleeding or thrombosis from lack of function or overfunctioning platelets

204

Myelofibrosis

what does it lead to

what cells does it make

myeloproliferative disorder (specifically Megakaryocytes)

JAK2 kinase mutation

marrow fibrosis - so the marrow cant make new RBCs which means you get extramedullat hematopoeisis in the spleen (splenomegaly)

Teardrop cell

 

 

205

Lymphoma

What are the subcategories

Tumor that arises from lymphocyte

Hodgkin lymphoma &

Non-Hodgkin Lym : Burkitt, DLBCL, Mantle, 

 

206

Follicular Lymphoma 

what is it/clinical signs

translocation

NHL

neoplastic Bcells (CD20) that make small follicle like nodules

Painless LAD (waxing and waning)

T(14;18) - switches heavy chain IG with BCL-2 (inhibits apoptosis) so you get over exp resion of BCL-2

207

What does BCL-2 do

cell marker that inhibits apoptosis

208

Mantle Cell Lymphoma

whats the translocation

neoplastic B cells that expand the mantle zone

t(11;14) cyclin D and IG Heavy chain

overexpression of cyclin D causes cell to go from G1 to S phase

209

What does Cyclin D do? 

causes cell to go from G1 to S phase in cell cycle

210

Burkitts Lymphoma 

What is it associated with

what are the 2 different forms

Translocation/ what does histo look like

neoplastic B cell prolif (CD20)

associated with EBV

-Endemic African: Jaw lesion // Sporadic: abdomen

t(8;14) : C-myc (promotes cell growth)

Starry Sky Appearance

 

211

Diffuse Large B-cell Lymphoma (DLBCL)

most common form of NHL

large nodes or extranodal mass

212

Hodgkin Lymphoma 

what cell do you see on histo

Reed-sternberg cells (owl eyes) CD15/30

you get B-symptoms: fever, night sweats, weight loss

213

Multiple Myeloma

what are some sypmtoms (CRAB)

which IG's are most spiked

associated with

Malignant proliferation of plasma cells in marrow 

Fried egg appearance

HyperCalcemia, Renal involvment, Anemia, Bone lesion (lytic- punched out)

M Protein spike (increase in Monoclonal immunoglobin (IG G/A)

Increased risk of infection, Rouleaux formation (stacked RBCs), Ig light chains in urine 

214

Monoclonal gammaopathy of undetermined significance (MGUS)

Waldenstrom macroglobulinemia

When you get an M spike but you dont have any of the CRAB symptoms of Multiple Myeloma

M spike of IgM with no CRAB. hyperviscosity syndrome like blurred vision and raynaud

215

Langerhan cell Histiocytosis

what would histo show

clinical signs?

proliferative disorder of (langerhan )dendritic cells found in skin. cells express s100

-Birbeck granules (Tennis racket)

-skin rash/ lytic bone lesion

216

what artery does horse shoe kidneys get stuck on?

inferior mesenteric artery

217

PKD

 

inherited defect

Bilateral Enlarged kidneys due to cysts in renal cortex and medulla

218

Autosomal Recessive PKD

what are the clinical signs

usually presents in infants.

Renal failure, HTN, Hepatic fibrosis

Potters Syndrome

219

Autosomal Dominant PKD

ADPKD (ADult)

where is the mutation? 

How do they present?

What other d.o's are they associated with?

 

The mutation is in PKD1(85%) or PKD2

-present with Flank pain, hematuria, HTN, Renal failure(Duh)

-Berry aneurysm, hepatic cysts, mitral valve prolapse

(cysts in the liver, brain, and kidney)

220

Medullary cystic Kidney Dz

what will the kidneys look like?

inherited defect of Cysts in the collecting ducts

Shrunken Kidneys

221

Azotemia

Increase in urine BUN and Creatinine

222

Acute Renal Failure

 

Abrupt decline in renal function measured by Azotemia (Increase in BUN and Creatinine

223

Pre-renal azotemia

Intra-renal failur

Post-real Azotemia

-Decrease in Renal BLood Flow

-Acute Tubular Necrosis

-Outflow Obstruction

 

224

Pre-renal azotemia

-Due to decrease in Renal blood flow (Hypotension)

-Increased BUN/Creatinine Ratio

(BUN is absorbed, creatinine is not)

Hypotension so the kidney is tryna hold onto whatever it can to conserve volume

BUN/Creatinine ration >20 

225

Acute Tubular Necrosis

(intra renal failure)

Whats seen in the urine casts?

what are serum and lab findings

What are the two ways to get it?

Injury and necrosis of Tubular epithelial cells. These necrotic cells plug the tubule which obstructs and Decreases GFR

-Muddy brown casts

-bc the epithelial cells are fucked you get messed up (decreased) resorption of:

BUN which means BUN:CR is <15

Na which means FeNA >2%

Inability to concentrate urine --- Osmalitly<200

-Ischemic & Neprotoxic

 

 

 

226

Ischemic Acute Tubular Necrosis (ATN)

which parts are most often fucked up

Decreased Blood supply results in necrosis of tubules

-PCT(proximal tubule) and Thick ascneding limb

227

Nephrotoxic Acute Tubular Necrosis (ATN)

What parts get fucked up?

what agents are nephrotoxic?

Necrosis of tubule cells due to toxic agents

-only PCT (proximal tubule)

-Aminoglycosides, heavy metals, Myoglobinuria (Crush injury), Ethylne Glycol, Radio contrast

228

Acute Interstitial Neprhitis

which drugs cause this?

what is a giveaway if you see it in the urine

what can it lead to?

Intra renal ARF (acute renal failure)

Drug induced hypersensitivity reaction 

-NSAIDs, Penicillins, Diuretics

-Eosinophils in the urine

-can lead to Renal Papillary Necrosis

229

Renal Papillary Necrosis

-clinical symptoms

-causes (SAAD Papa)

Necrosis of Renal papillae

Gross Hematuria and flank pain

-causes: Sickle cell, Acute pyleonephritis, Analgesics(Nsaids), Diabetes Mellitus

230

NephrOtic Syndrome

Whats the main hallmark of this?

what all lost becasue of it

List all 6 dz that leads to this

-  PrOteinuria (>3.5g/day). due to any damage of the GFR barrier

Loss of Albumin which causes EDEMA

Loss of immunoglobulins --> increased infections 

Loss of Antithrombin III(ATIII) --> Hypercoag

Hyperlipidemia- frothy urine 

-Minimal Change Dz, Focal segmental glomerulosclerosis (effacement of podocytes)

-Membranous Nephropathy, MPGN (deposition of immune complexes)

-Diabetic Glomerulonephropathy, Amyloidosis

 

231

Minimal Change Dz (MCD)

who gets it

what causes this which can be seen on EM

which protein do you lose?

treatment?

most common cause of NephrOtic syndrome in kids

-effacement of foot processess (podocytes) due to cytokines

you only lose albumin

-tx: Steroids

232

Focal Segmental Glomerulosclerosis

Who usually gets this?

What is it associated with

what what it look like on histo

whats special about the treatment and what can it progress to

 

-most common cause of NephrOtic syndrome in Hispanics and Blacks

-HIV, Heroine, and Sickle cell

-Focal (not all glomeruli) Segmental (only part of affected glomeruli) Slcerosis (deposition of pink collagen)

-poor response to steriods and can progress to chronic renal failure

233

Membranous nephropathy

who gets it

whats it associated with

whats it look like on histo due to?

Most common cause of NephrOtic syndrome in Caucasian adults

-Hep B/C, Solid Tumors, SLE

Very thick membranes due to immune complex depositions

-Spike and Dome on EM

234

Membrano-Proliferative Glomerulonephritis

what does it look like on stain

divided into two types. explain them and what they are associated with 

Thickening of the glomerular membrane due to deposits of Immune complexes

Tram Track appearance because the membrane gets split by the mesangial cells

-Type 1: Subendothelial deposits. Hep B/C

-Type 2: Basement Membrane deposits. C3 Nephritic factor (activates complement by stablizing C3 convertase) 

235

Where are the immune deposits in MPGN (membranous proliferative glomerulonephritis) and Membranous nephropathy

MPGN type 1: Subendothelia

MPGN type 2: basement membrane

Membranous: subepithelial 

 

236

Diabetic Glomerulonephropathy

What does the diabetes do? how to treat it

what kind of nodules will you see?

cause of NephrOtic syndrome

High blood sugar leads to Nonezymatic glycosylation of GBM

leads to leaky and thickening 

also increase in GFR due to constriction of efferent arteries (can be treated with Ace inhibitors 

kimmelstiel-wilson nodules

237

Amyloidosis

what will stain show?

Cause of NephrOtic syndrome

Kidney is the most common organ of Amyloid deposition

Congo Red stain shows apple-green birefiringence

238

NephrItic Syndrome

whats the hallmark finding

what causes the finding

What are the different types

-Glomerular Inflammation and bleeding that leads to hematuria and RBC casts in urine

limited proteinuria (<3.5g/day)

-deposition of immune complex triggers inflammation

-Types: Post Strep Glomerulonephritis, Rapidly progressive glomerulonephritis (Crescentic), IgA nephropathy

239

Post Strep GlomeruloNephritis (PSGN)

when does it occur and the virulence factor

Clinical presentation

-whats it look like on histo

how do you treat it?

Main cause of NephrItic Syndrome

-occurs after group A, ß hemolytic strep infection of skin or throat

-M protein

-Periorbital Edema, Cola Urine, Hypertension

-"Lumpy bumpy Hump"  GRANULAR on Basement membrane

-it usually resolves on its own

240

Rapidly Progressive Glomerulonephritis (Crescentic)

what are the crescents made of?

What will the Immunoflorescence look like?

A cause of NephrItic syndrome that progresses to renal failure in weeks to months

Crescents in the glomerulus 

-crescents consist of Fibrin and plasma proteins

Linear: Antibodies to basement membrane = Goodpasture syndrome

 

241

IgA Nephropathy

(Berger Dz)

when do you usually get it?

Cause of NephrItic Syndrome

IgA immune complex deposition in Mesangium of Glomeruli

Concurrently with Respiratory or GI Tract infection (the IgA gets secreted by mucosal linings)

242

Alport Syndrome

 

cause of NephrItic syndrome

inherited (X-linked) defect in Type 4 collagen

-thinning and slpitting of the GBM

isolated hematuria

Eye problems, ear problems kidney problmes, 

cant see, cant pee, cant hear a bee

243

Urinary Tract infection

whos at higher risk

whats in the lab findings 

which bacteria cause these?

 

what if you have a negative culture

Infection of urethra, bladder (cystitis), or kidney

most commonly ascending infection, women are more risk due to shorter urethra

+ Leukocyte esterase, + nitrites, 

urine culture >100k

-E Coli > Staph saprophyticus > Klebsiella > Proteus mirabilis (pee has ammonia scent)

-negative culture suggests Neisseria gonorrhoaeae / Chlamydia

244

Pyelonephritis (acute)

how does it present?

whats in the urine

Infection of the kidney (usually due to ascending infection)

-fever, flank pain (Costovertebral angle)

WBC casts in urine

245

Pyelonephritis (Chronic)

which abnormality usually causes this

what does this look similiar to/mimic on histo

when you get acute pyelonpehritis a bunch and you get atrophy and fibrosis of the tubules

-vesicoureteral reflux (relfux back into the ureters up to the kidney)

cortical scarring with blunted calyx

"thyroidization"

246

Kidney stones

symptomes

what kind of stones are there and shape/associations/tx

Colicky pain with unilateral flank tenderness, hematuria

-Calcium oxylate (most common): envelope,chrons dz, tx=HCTZ

-Amonium magnesium phosphate: coffin, ureas(+) organisms: Proteus or Klebsiella tx=surgically remove (Staghorn)

-Uric acid: rhomboid, acidic ph/hot climate/gout(duh), tx=Allopurinol

-Cysteine: seen in children, genetic defect where you dont reabsorb Cysteine, Staghorn

 

247

Renal Cell Carcinoma

classic symptoms

what can it be associated with

what does it look like grossly

what mutation leads to this and which chromosome is it on

-hematuria, palpable mass, flank pain

-associated with paraneoplastic syndromes (ectopic EPO, ACTH, PTHrP, renin)

-golden yellow mass + clear cell

Loss of von hippel-lindau (VHL) suppresor gene on Chromosome 3

smoking

248

Wilms Tumor

how does pt present

which mutation?

what syndrome can this be a part of?

Most common kidney tumor in kids

-blastema

-Large palpable unilateral flank mass, hematuria, HTN 

-Loss of function of WT1 or WT2 

WAGRWilms, Aniridia(no iris), GU malformations, mental Retardation

 

249

main cause of rhinitis

what is a major consequence it can lead to

adenovirus

nasal polyps

250

when a child has nasal polyps what should you be thinking?

Cystic fibrosis

ASA (asprin) intolerant asthma

251

main cause of epiglottitis

H. influenza

252

Pneumonia

what does the sputum look like?

percusion?

3 types of pneumonia?

Infection of lung parenchyma

-yellow green or rusty colored sputum

-dull percusion

-Lobar, Bronchopneumonia, Interstitial 

253

Lobar Pneumonia

which are the two most common causes

consolidation of an entire lobe

usually bacteria

S. Pnuemonia (95%) & Klebsiella Pneumoniae

254

Bronchopneumonia

which bacteria causes this

scattered patchy pneumonia cetered around the bronchioles

-S. A, H. influ, S. pneumonia, klebsiella

255

interstitial (atypical) pneumonia

why is it called Walking Pneumonia

What causes it

diffuse interstitial infiltrates

-has very mild symptoms

-Mycoplasma pneumonia (military recruits or college kid), Chlamydia Pnuemonia, RSV (infants) , CMV (post transplant)

256

Tuberculosis

whats the PPD

primary/secondary?

inhalation of Mycobacterium Tuberculosis 

-caseating necrosis of lower lobe

-Ghon complex (fibrosis and calcification)

-PPD (+)

Secondary- reactivation of TB due to AIDs (APEX) of lung. CASEATING granulomas

257

COPD

whats the spirometry readings

types

obstruction of getting air OUT of the lung

ForcedVC (down), FExpiratoryV1(down-down)

TLC(up) due to lung trapping of air

-Chronic Bronchitis, Emphysema, Asthma, Bronchiectasis

258

Chronic Bronchitis

how does one get it

Whats the Reid index and whats the value for CB

How do they present

whats a bad thing this can lead to

Hyperplasia of mucus secreted glands as a result of smoking

Reid index is the thickness of mucosal gland layer to the thickness of wall btwn epithelium and cartilage. For CB its >50%

-presents with Productive Cough, Cyanosis

-Cor Pulmonale (hypoxia leads to vasoconstriction to area and shunting to other areas in lung--> failure of right heart)

259

Emphysema 

what imbalnace/deficiency causes this?

most common cause of this?

what are the two types? which lobes are they associated with?

whats a nickname for this?

Destruction of alveolar sacs

loss of elastic fibers, increased compliance, "Shopping bag', AIrway collapse

Lack of Alpha 1 AntiTrypsin (A1AT)

-SMOKING (duh bruh)

Centriacinar (smoking-upper lobes)

Panacinar (A1AT deficiency- lower lobes)

-PINK PUFFER (barrel chest)

 

260

Asthma

Reversible Bronchospasm most often due to allergic stimulus

IgE Hypersensitiviy type 1 mediated

261

IL-4

IL-5

IL-10

4 - IG class switching

5 - calls in eosinophils

10 - stimulates th2 T cells

262

Bronchiectasis 

what causes it?

Permanant dilation of the bronchioles and bronchi

loss of tone leads to air trapping

(think of blowing throught a big pipe)

-necrotizing granulation of airway wall

secondary amyloidosis

263

Restrictive respiratory DZ

whats the FEV:FVC ratio?

Restricted filling of the lung mostly due to FIBROSIS

 Ratio is INCREASED >80%

Idiopathic pulmonary fibrosis

264

Idiopathic pulmonary fibrosis

what does lung look like?

Treatment?

repeated wound healing with collagen deposition

Honeycomb lung appearance

lung transplant

265

Pneumonconioses

Interstitial fibrosis due to occupational exposure

coal worker, silicosis, abestosis

266

coal workers pneumoconioses

whats caplan syndrome?

Anthracosis?

Restricitve lung dz (fibrosis) 

Black lung

macrophages laden with carbon lead to inflammation and fibrosis

caplan: rheumatoid arthritis and penumonconioses

Antrhacosis: carbon in the lung thats assymptomatic 

267

Silicosis

how does it affect macrophages?

whats special solely about this pneumocon.?

what part of lung does it affect? (roof and base)

Restrictive lung dz (pneumoconioses)

-sandblasting, mines 

-it impairs the phagolysosome

-its the only wone that increases chance of TB

"silica and coal are on the base, but affect the roof"

(upper lobe)

 

268

beryliosis

restrictive lung dz (pneumoncon.)

exposure to beryllium in aerospace 

non-caseating  granulomas

269

Asbestosis

where does it affect the lung

what do you look for to confirm diagnosis

restrictive lung dz (pneumocon)

Associated w/ shipbuilding, roofing, plumbing. 

lower lobe

-asbestos (ferrunginous) bodies: golden brown rods

 

270

Sarcoidosis

which type of lesion and where will you find them

who gets it?

what else type of cell can you see in this histo?

what values are elevated?

why does this cause hypercalcemia?

Restrictive lung dz

"noncasesating granuloma" in multiple organs (speccifically lung and hilar lymp nodes)

African american femal under 40yrs old

-asteroid body 

-elevated ACE levels, CD4/8 ratio

-due to incr. 1Alpha-hydroxylase vit D activation in macrophages

 

271

Lung cancer

Small cell carcinoma

who gets it, where is it located, what does it produce

poorly differentiated small cells

Male smokers, Centrally,

may produce ACTH or antibodies against PRESYNAPTIC Ca+2 channels (lambert-eaton)

272

lung cancer

Squamos cell carcinoma

Whats the big clue on histo

where is it? what symdrome?

Keratin pearls and Intercelluar bridging

-Central 

-produces PTHrP (hyperCalcemia)

273

lung cancer

Adenocarcinoma

who gets these/why is it special?

where is it located

-characterized by glands or mucin production

-most common cancer in Non-Smokers,

-Peripheral

274

Lung cancer

Large cell carcinoma

-no keratin pearls, no glands or mucin

smoking, 

central or periph 

(grab bag)

275

lung cancer

-Carcinoid tumor

what kind of cells, whats growth look like

well differentiated, nest of nueroendocrine cells

chromogranin (+)

polyp like growth 

276

Lung cancer (general facts)

where does it metastisize?

Where does it get mets from?

what complications does it cause 

mets to the adrenals

mets from the breast, colon, prostate

SPHERE of complications

-Superior Vena Cava syndrome, Pancoast tumor, Horner syndrome, Endocrine (paraneoplastic), Recurrent laryngeal nerve (hoarseness), Effusions (plueral)

277

Pneumothorax

What are the types and describe them

Accumulation of Air in the Pleural space

Spontaneous: Rupture of bleb or cysts. collapse of the lung w/ trachea shifting to collapse 

Tension: caused by penetrating chest wall injury. trachea is pushed to opposite side of injury. (this is the one with the flap. air gets in but cant get out. pushes the trachea away)

278

Mesothelioma

how does it present?

what occupational hazard can cause this

Malignancy of the Mesothelial cells 

Presents with recurrent pleural effusions

-Asbestos

279

Whats up with DiGeorge Syndrome?

whats the deletion

how does it present?

Developmental failure of 3rd/4th pharyngeal pouch

-22q11

-T-cell deficiency (Lack of Thymus)

-Hypocalcemia (Lack of parathyroid)

-Cardiac Defects

280

Whats up with SCID?

what are the deficiencies?

tx?

Defective cell mediated (T-cell) and Humoral mediated (B-cell) immunity

-Adenosine Deaminase Deficiency 

MHC class II deficiency

-bubble boy/ bone marrow transplant

281

whats up with X-linked agammaglobulinemia

whats the defect?

when do you get it? why?

-fuck up of B-cell maturation

complete lack of immunoglobulins 

-defect in BTK (Bruton Tyrosine Kinase)

-After 6 months of life which is when maternal IgG depletes

282

Common Variable Immunodeficiency

B-cell defect. 

low immunoglobulin 

-increased risk of autoimmune dz and lymphoma

283

Selective IgA deficiency

What type of infections

-low serum IgA (duh)

-mucosal infections 

284

Hyper IgM Syndrome

wheres the mutation

what type of infections?

increased levels of IgM 

mutation at CD40L (cant class switch)

-decreased IgA, IgE, IgG

Pyogenic infections, mucosal infections

285

Wiskott-Aldrich Syndrome

(W.A.T.E.R)

-Mutation in WAS gene

-Wiskott Aldrich Thrombocytopenia Eczema Recurrent infections

286

Systemic Lupus erythematosus

Presentation

labs?

Autoimmune Dz

-Malar "butterfly" Rash. Chronic inflam, Arthritis, CNS psychosis

Renal Damage (Cause of death)/ Heart problems

Libman-Sacks-Endocarditis (SLE-->LSE) Vegetations on both sides of a valve

-Antinuclear antibody (ANA) + Anti-dsDNA 

287

What are the Lupus causing drugs?

what antibodies do they produce?

Hydralazine, procainamide, Isoniazid

AntiHistone antibodies

288

Anti-phospholipid syndrome

what are the two antibodies?

what can they lead to?

tx?

Associated with Lupus

Autoantibody associated with proteins on phospholipid. Hypercoag state

Anticardiolipin + lupus anticoagulant (falsely increases PTT)

false positive syphillis test

-life long anticoag tx

289

Sjogren Syndrome

presentation?

lab test? what other dz is SS associated with?

what could enlarged parotids lead too?

Autoimmune destruction of Lacrimal and Salivary glands.

-dry eyes, dry mouth, dental carries

-presence of ANA: Anti-SS-A/ Anti-SS-B (ribonucleoproteins) 

-Rheumatoid arthitis

-enlarged parotids=could mean B Cell Lymphoma

 

 

290

Scleroderma

Diffuse vs Localized

Triad: Autoimmunity, noninflam vasculopathy, Collagen depositions w/ Fibrosis 

Diffuse: widespread involvement of skin and viscera. Anti SCL-70 antibody (Anti-DNA Topoisomerase I antibody)

Localized: local skin involvment of fingers and faceCREST syndrome- Calcinosis/anti Centromere ab, Raynauds, Esophageal dysmotility, Sclerodactyly, Telangeictasia

291

Mixed Connective Tissue Dz

whats the antibody?

Grab bag of a lil bit of SLE, Scleroderma, polymyosistis

Anti-U1 RNP antibodies

292

What are the layers of the epidermis? from surface to deep. what are found in each 

Stratum Corneum (keratin)

Lucidum

Granulosm

Spinosum (desmosomes)

Basale (stem cells)

293

Whats atopic dermatitis?

where does it usually appear?

what type of hypersensitivity?

aka Eczema

face and flexor surfaces

TYPE I

294

Contact Dermatitis

what type of hypersensitivity 

tx?

Poison Ivy, Nickel, neomycine

Type IV (delayed)

-remove offending agent/topical steroids

295

Acne

whats it due to?

what type of infection

tx?

comedones (white heads and black heads), pustules (pimples) 

Chronic inflammation of the hair follicles and sebacious glands 

Proprionibacterium acnes (P. acnes)

-retinoids, benzoyl peroxide, antibiotics 

 

296

Psoriasis

whats it look like/ where is it found

whats another clinical sign it can be found with?

whats Auspitz sign?

tx?

excessive keratin proliferation: Parakeratosis (nuclei still in Stratum Corneum)

well-circumscribed "salmon colored" plaques with silvery scales

-extensor surfaces and scalp

-nail pititng

Auspitz: pinpoint bleeding after removing a scale

-corticosteroids/

297

Lichen Planus 

how does histo look?

which other infection is it associated with?

Pruritic, purple, polygonal planar papules and plaques

-Sawtooth infiltrates of Lymphocytes at dermal-epidermal junciton

-Hep C

298

Pemphis Vulgaris

whats histo like? what layer is messed up

whats the clinical sign/finding?

what does immunoflourescence look like?

which type of skin does it involve?

Autoimmune destruction of Desmosomes via IgG antibodies

-tombstone appearance since basment cells are intact while the Stratum Spinosum is fucked up

-Separation of epidermis upon touching the skin (wet blisters)

-Net-like 

-skin and oral mucosa

299

Bullous Pemphigoid

what will immunoflourescene look like?

how do the blisters look?

Autoimmune Destruction of Hemidesmosomes via IgG antibodies

-Linear pattern

oral mucosa isnt affected

-Tense Blisters that dont rupture easily

300

Dermatitis Herpetiformis

what do the lesions look like?

what dz is associated?

how do you treat it?

Depositions of IgA at tips of dermal papillae.

-herpes; so tiny vesicles that are grouped together

-Celiac dz

-dapsone/gluten free diet

301

Erythema Multiforme

what kind of skin lesions?

what are some associations?

Hypersensitivity reaction w/ Target Lesions

-HSV, M. pnuemo, sulfa drugs

302

Steven Johnson Syndrome

whats TEN?

Erythema Multiforme w/ oral mucosa and Fever 

-Toxic epidermal necrosis: Sloughing off of the skin

303

Sborrheic Keratosis

whats it called when you have a sudden appearance of these? 

morgan freeman, looks stuck on

Leser-Trelat sign: sudden onset, usually a sign of malignancy (usually GI)

304

Acanthosis Nigricans

(thick epidermis) (dark)

what is it? where is it usually found?

what causes/associated with it?

Thickening of the skin

usually on the groin or axilla

-diabetes, obesity, cushings, malignancy

305

Basal cell carcinoma of the skin

what are the risk factors?

whats it look like?

whats a key finding on histo? 

tx

most common skin cancer

-exposure to UV sunlight 

-raised lesion/central ulcer/dilated blood vessels (telangiectasias)

-palisading nuclei 

-tx: excision

306

Squamous cell Carcinoma of the skin

what are some risk factors?

where is it usually found?

tx

whats usually its precursos

malignant proliferation of squamous cells

-sunlight, immunosupression, arsenic

-LOWER LIP

-excision

-Actinic keratosis

307

Actinic Keratosis

precursor to squamous cell

308

Keratoacanthoma

well differentiated SCC

volcanic lesion that forms quickly and resolves quickly as well

309

what level in the skin are mealoncytes found?

what embryo structure is it derived from?  

where does it synthesize melain?

in the Basal cells

-neural crest

-synthesizes melanin in the melanosome

310

Vitiligo

Autoimmune destruction of the melanocytes

- localized  loss of skin pigmentation

311

Albinism

whats the enzyme defect?

what are the 2 types?

what can it lead to?

Congenital lack of pigmentation

--defect in Tyrosine transport (impairs melanin production)

-eyes or eyes/skin

-increased risk of skin cancer

312

why are freckles present/darker than rest of skin?

they have increased number of melanosomes in their cells

313

whats Melasma?

hyperpigmentation of the cheeks associated with pregnancy or OCP use

314

Nevus (moles)

whats a junctional nevus?

Junctional: increased melanocytes at dermal-epidermal junction. these guys are Flat

315

Melanoma

subtypes: nodular/lentiginous/acral

Malignant neoplasm of melanocytes

most common cause of Death in skin cancer

nodular: bad prognosis, creates huge bump

lentignious: good prognosis (radial prolif along the dermal epidermal junction)

acral: on the hands and feet of dark skinned ppl

316

Impetigo

skin infeciton caused by SA and Strep pyogenes

Honey colored crusting

317

Cellulitis

risk factors?

deep skin infection (bacteria to the dermis

red, tender swollen rash 

-trauma, bug bite, surgery

318

Necrotizing fasciitis

 

Necrosis of Subcutaneous tissue below the dermis

caused by anaerobic flesh eating bacteria 

produciton of CO2 leads to crepitus

 

319

Staph scalded skin syndrome

difference between this and TEN (toxic epidermal necrosis)

Exotins A&B destroy keratinoctye attachments in stratum granulosom from rest of skin 

-sloughing of skin with rash and fever

-TEN has separation at the dermal-epidermal junction where as SSS is stratum granulosom

320

which hormones do prolactin inhibit

what inhibits prolactin secretion

GnRH 

-dopamine

321

whats sheehan syndrome

what are some clinical signs

In pregnancy the pituitary gland doubles in size, however, the blood flow doesnt increase to match it so it doubles in size

-poor lactation and lossof pubic hair

322

Condyloma

what is it? whats main cause

Warty neoplasm of genital area

-HPV 6 and 11.

-koilocytic change

323

Lichen Sclerosis

 

Thinning of the epdiermis/fibrosis of the dermis of the vag

-cigarrete "parchment" paper skin 

324

lichen simplex chronicus

what causes it

hyperplasia of vulvar epithelium

-thickening of the skin

-chronic itching and scratching

325

Pagets dz of the vulva

malignant epithelial cells of the epdiermis

-erythematous, pruritc, ulcerated skin

 

326

Clear Cell Adenocarcinoma

whats an old drug that causes this?

Malignant proliferation of glands with clear cytoplasm

-DES

327

Embryonal Rhabdomyosarcoma

Grape-like protrusion 

malignant mesenychmal cells of immature skelatal muscle

328

Lymph node spread of upper and lower vag carcinomas

upper 2/3 -- inguinal

lower 1/3 - illiac nodes

329

What causes acute endometriitis 

left over products of conceptions 

330

endometrial polyps

major presentation

painless uterine bleeding

331

Endometriosis

endometrial glands and stoma outside the uterine lining

332

whats a chocolate cyst?

its when the ovary is filled by endometriosis 

333

Adenomyosis

Extension of the endometrial tissue (endometriosis) into the myometrium 

334

Endometrial hyperplasia

what causes it?

how does it present

most important predictor for progression to carcinoma?

abnormal endometrial GLAND proliferation (relative to stroma)

-excess estrogen stimulation

-post menopausal vaginal bleeding

-nuclear atypia

335

Endometrial Carcinoma

how does it present

Malignant prolif of endometrial glands

post menopause bleeding

336

Leiomyoma (fibroid)

how dangerous are they?

Benign proliferation of smooth muscle from myometrium

multiple, well-circumscribed tumors that increase during pregnancy

-asymptomatic, but sometimes can cause bleeding

337

whats the functional unit of the ovary?

Follicle 

338

Polycystic Ovariand Dz (PCOD)

what causes it?

classic presentation

what can it usually lead to?

hormone imbalnce -> incr. LH/ low FSH

-too much LH leads to incr. androgen production. that androgen goes to the periphery and gets converted to estrogen which then goes to pituitary and shuts down FSH (neg. feedback)

w/o FSH the ovary atrophies and creates a cyst

-obese woman, hirsutism, infertiliity,

-insulin resistance/diabetes

339

when would you use the serum marker CA 125

to monitor for treatment and Recurrance 

340

Mature cystic teratoma of the ovaries

what type of tumor (Surface epithelia, Germ cell, Sex cord stroma)

what do the cysts contain

Immature cystic teratome

Germ cell

Contains fetal tissue from all 3 germ layers

Benign

______________________

Immature contains immature tissue (ie neuroectoderm)

341

cystic teratoma composed of thyroid tissue

Stuma ovarii

342

Dysgerminoma

malignant ovarian tumor

Sheets of uniform "fried egg" cells (large cells with central nuclei and clear cytoplasm)

 

343

Yolk sack tumor (whats another name for it)

most common germ cell in ____

whatst the major tumor marker

what cells do you see on histo

Endodermal sinus tumor

most common germ cell in kids

AFP

Schiller-Duval bodies (central vessel looks like glomeruli) *glomeruloid like structures

344

Choriocarcinoma

whats it composed of?

lab abnormalities?

how does it spread?

Malignant prolif of placenta tissue

-trophoblasts and Syncytiotrophoblasts 

Villi are absent

Very high ß-hCG

-hematogenously

345

Granulosa-Theca cell tumor

sex cord stromal tumor

neoplasm of granulosa/theca cells (duh)

production of estrogen/progestorone which will have differnt affects at different ages

346

Fibroma

Associated with _____ syndrome. which is

Benign tumor of Fibroblsts

Meigs Syndrome: Fibroma, Ascites, Hydrothorax

347

Krukenberg tumor

what does it secrete?

Gi malignancy that mets to ovaries

mucin secreting signet cell adenocarcinoma

348

Psuedomyxoma peritonei

where does it usually come from

intraperitoneal accumulation of mucin material

usually arises from Appendix tumor

349

Ectopic pregnancy 

whats the most common site?

big risk factor?

clinical presentation

fertilization and implantation of ovary at site other than uterine wall.

-ampulla of Fallopian tubes 

-scarring (from PID-salpingitis, endometriosis)

-lower abdominal pain after missed period (ALWAYS DO PREGNANCY TEST)

350

Spontaneous abortion

loss of fetus before 20 wks

passage of fetal tissues

351

differences between 

Placenta Accreta/Increta/percreta

and presentations

Accreta: placenta attaches to myometrium w/o penetration. difficulty delivering placenta

 

 

 

352

HELLP syndrome

Preeclampsia w/ thrombotic microangiopathy of the liver

Hemolysis, Elevated Liver enzymes, Low Platelet

HELLP

353

Sudden infant Death Syndrome (SIDS)

risk factors

Death of infant 1mo. - 1 yr. without cause

-sleeping on stomach, smoking in house, 

354

Hydatidiform mole

how do you diagnos

Tx?

instead of growing a baby you grow abnormal placental tissue

swollen and edematous villi, proliferation of trophoblasts

-passage of "grape-like" masses / snowstorm on US

-dilation and curettage of mole, monitor b-hcg

355

Complete Hydatidiform Mole

whose fault? fetal parts? villi? b-hcg

All dads fault (only sperm and enucleated egg)

46,XX; 46, XY

-no fetal parts

-All villi are edematous/fucked up

-b-hcg much higher than partial mole

356

Partial Hydatiform mole

fetal tissue? villi?

2 sperm + 1 egg

69 XXX; 69, XXY; 69, XYY

Yes fetal parts

some villie are fucked

 

 

357

What causes Hypospadias?

failure of the urethral folds to fuse

pee out the bottom of your weewee

358

what causes Epispadias?

what other abnormality is it associate with?

faulty positioning of the genital tubercle

bladder Extrophy (protrusion of the bladder)

359

Squamous cell carcinoma of the penis

major risk factors

precursor lesions:

malignant prolif of squamos cells of the penis

High risk HPV/lack of circumcision

-Bowens dz: shaft

Erythoplasia of Queyrat: glans

Bowenoid papulosis: reddish papules

360

Cryptorchidism

major complication?

undescended testicle

-usually self resolving but after age 2 it can lead to testicular atrophy/increased risk of seminoma

361

testicular Varicocele

which side is most common

"Bag of worms"

Dilated veins

-usually left sided due to drainage into left renal vein

362

what causes testicular hydrocele?

incomplete obliteration of processus vaginalis (infants)

or blockage of lymph drainage (adults)

363

Acute Prostatitis

buzzwords for clinical presentaiton?

Chronic Prostatis

 

-Tender and Boggy

________________

Lower back/pelvic pain

364

Benign prostatic hyperplasia

what causes it

what it can lead to

tx-

hyperplasia of the prostate around the lateral/middle lobes. increased PSA

Not premilignant 

-increase of DHT

-hydronephrosis

-tx: a-blocker (terazosin), 5a-reductase inhibitor

 

365

Prostatic adenocarcinoma

how is it diagnosed

where does it met to?

Malignant prolif of prostatic glands

Most common cancer in men  

arises in peripheral zone

-diagnosed by Incr. PSA / decr. fraction of free PSA

-mets to the bone (lower back pain)

 

366

What are the lobules and ducts lined by in the breast?

luminal cell layer

myoepithelial cell layer (contractile function)

367

Acute Mastitis

which organism causes this

Staph Aureus.

infection of the duct, purulent discharge

 

368

Fat necrosis

what does the biopsy show?

benign lump due to injury to breast tissue

necrotic fat with calcifications and giant cells

369

Fibrocystic changes

most common in premenopausal women

lumpy breasts, Blue dome cysts

370

whats Sclerosing adenosis

fibrosis of the acini and stroma of the breast

associated with calcifications

371

Intraductal papilloma

most common cause of _________

papillary= long like finger pertrusion in the lactiferous duct

most common cause of BLOODY NIPPLE

372

Fibroadenoma

estrogen sensitive?

Most common tumor in premenopausal females 

tumor of fibrous tissue and glands

well circumscribed, mobile, marble like

-yes

373

Phyllodes Tumor

benign breast tumor with Leaf like lobulations

374

Ductal carcinoma in Situ (breast)

how is it detected on mammography

whats the comedo subtype

Malignant proliferation of cells in ducts

No invasion into the basement membrane

-micro calcifications

-Comedo:high grade cells w/ necrosis and dystrophic calcification in center

375

Paget's dz of the breast/nipple

how does it present?

DCIS that extends to the nipple

-nipple ulceration/erythema 

376

Invasive ductal Carcinoma (breast)'

advanced tumors can cause ____

forms rock-hard "duct like" structures

-dimpling of skin / retraction of nipple

377

Inflammatory breast cancer

what does the breast look like?

prognosis

Cancer of the Dermal lymphatics 

Peau d'orange (breast dimples like orange skin)

Large boob

pretty bad prognosis

 

378

Invasive lobular carcinoma

how does it look?

Orderly row (Indian file) of cells due to decr. E-cadherin

379

Whats a pleomorphic adenoma

whats it composed of?

where does it usually arise?

whats the tumor look like? special about it?

A bening mixed tumor of the salivary glands

-most common salivary gland tumor

-composed of stromal and epithelial cells

-parotids

-mobile, painless, and circumscribed

-high rate of recurrance

380

Warthin Tumor 

benign cystic tumor with germinal centers

-contains lymphnode tissue

381

Mucoepidermoid carcinoma

most common malignant tumor of the salivary glands

-mucinous and squamous components