1. Neurophysiology part II Flashcards Preview

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Flashcards in 1. Neurophysiology part II Deck (19):
1

___ toxin: blocks voltage gated Na+ channels

tetrodotoxin
- blocks AP
= death, paralysis

2

tetrodotoxin blocks ____ channels. This cause a ____ not to be propogated resulting in death/ paralysis

voltage gated Na+ channels

causes an AP not to occur

3

____ toxin: blocks vesicle fusion at neuromuscular jxn

botulimum

- blocks actin moving myosin
(cant move the forehead)

4

____ toxin: blocks K+ channels

apamin
- blocks repolarization = spasms

5

apamin blocks K+ channels and causes ___ to not occur

repolarization

6

Curare toxin blocks ___ receptors

nicotinic receptors (AcH)
effect- M weakness

7

What are the two types of postsynaptic respinsees to NT release in the synapse

1. Graded response (aka electrotonic)
2. AP

8

EPSP is mediated by ___ ion influx

Na+

9

IPSP is mediated by ____ ion influx

Cl-

10

____ are the sum result of graded responses

AP

11

_______ theory: only specific neurons respond to NT release

Lock and key receptor specificity

12

What are two ligand-mediated receptors?

1. iontrophic
2. metatrophic

13

____ is a ligand mediated receptor that requires G protein coupling

Metatrophic ligand

(slower than iontrophic)

14

Ea Neuron has its own ___ identity

NT identity

15

____ is the most prevalent excitatory NT

Glutamate

16

___ pathological process by which nerve cells are damaged and killed by excessive stimulation by neurotransmitters such as glutamate

excitoxic

17

____ is the most prevalent inhib NT

GABA
- binds post synaptic & binds with Ca2+ (ISPS)

18

AA NT inhibitor that is found mainly in the SC

glycine

19

Glutamate and GABA are recycled by ___

astrocytes