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Pharm U5 > 1) Steroids U5 > Flashcards

1) Steroids U5 Flashcards

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1
Q

What is the class for Cortisol

A

Glucocorticoid

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2
Q

What is the mechanism for Cortisol

A

Binds GR, which regulates expression of genes with many effects on carbohydrate metabolism and immune function

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3
Q

What are the important side effects for Cortisol

A

Cushing’s; glucocorticoid-induced osteoporosis; iatrogenic adrenal insufficiency

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4
Q

What are the miscellaneous for Cortisol

A

RelAnti-Inflam: 1; RelMin: 1; DoA: 8-12 hours

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5
Q

What is the class for Cortisone acetate (Cortone)

A

Glucocorticoid

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6
Q

What is the mechanism for Cortisone acetate (Cortone)

A

Binds GR, which regulates expression of genes with many effects on carbohydrate metabolism and immune function

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7
Q

What are the important side effects for Cortisone acetate (Cortone)

A

Cushing’s; glucocorticoid-induced osteoporosis; iatrogenic adrenal insufficiency

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8
Q

What are the miscellaneous for Cortisone acetate (Cortone)

A

RelAnti-Inflam: 0.8; RelMin: 0.8; DoA: 8-12 hours

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9
Q

What is the class for Hydrocortisone

A

Glucocorticoid

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10
Q

What is the mechanism for Hydrocortisone

A

Binds GR, which regulates expression of genes with many effects on carbohydrate metabolism and immune function

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11
Q

What are the therapeutics for Hydrocortisone

A

Chronic primary adrenal insufficiency (maintenance); CAH

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12
Q

What are the important side effects for Hydrocortisone

A

Cushing’s; glucocorticoid-induced osteoporosis; iatrogenic adrenal insufficiency

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13
Q

What are the miscellaneous for Hydrocortisone

A

RelAnti-Inflam: 1; RelMin: 1; DoA: 8-12 hours

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14
Q

What is the class for Prednisone (Deltasone)

A

Glucocorticoid

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15
Q

What is the mechanism for Prednisone (Deltasone)

A

Binds GR, which regulates expression of genes with many effects on carbohydrate metabolism and immune function

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16
Q

What are the therapeutics for Prednisone (Deltasone)

A

CAH

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17
Q

What are the important side effects for Prednisone (Deltasone)

A

Cushing’s; glucocorticoid-induced osteoporosis; iatrogenic adrenal insufficiency

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18
Q

What are the miscellaneous for Prednisone (Deltasone)

A

RelAnti-Inflam: 4; RelMin: 0.8; DoA: 12-36 hours; 1/4 dose of cortisol

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19
Q

What is the class for Prednisolone (Orapred)

A

Glucocorticoid

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20
Q

What is the mechanism for Prednisolone (Orapred)

A

Binds GR, which regulates expression of genes with many effects on carbohydrate metabolism and immune function

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21
Q

What are the important side effects for Prednisolone (Orapred)

A

Cushing’s; glucocorticoid-induced osteoporosis; iatrogenic adrenal insufficiency

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22
Q

What are the miscellaneous for Prednisolone (Orapred)

A

RelAnti-Inflam: 4; RelMin: 0.8; DoA: 12-36 hours; 1/4 dose of cortisol

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23
Q

What is the class for Methylprednisolone (Medrol)

A

Glucocorticoid

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24
Q

What is the mechanism for Methylprednisolone (Medrol)

A

Binds GR, which regulates expression of genes with many effects on carbohydrate metabolism and immune function

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25
What are the important side effects for Methylprednisolone (Medrol)
Cushing's; glucocorticoid-induced osteoporosis; iatrogenic adrenal insufficiency
26
What are the miscellaneous for Methylprednisolone (Medrol)
RelAnti-Inflam: 5; RelMin: 0.5; DoA: 12-36 hours; 1/5 dose of cortisol
27
What is the class for Triamcinolone
Glucocorticoid
28
What is the mechanism for Triamcinolone
Binds GR, which regulates expression of genes with many effects on carbohydrate metabolism and immune function
29
What are the important side effects for Triamcinolone
Cushing's; glucocorticoid-induced osteoporosis; iatrogenic adrenal insufficiency
30
What are the miscellaneous for Triamcinolone
RelAnti-Inflam: 5; RelMin: 0; DoA: 12-36 hours; 1/5 dose of cortisol
31
What is the class for Dexamethasone (Decadron)
Glucocorticoid
32
What is the mechanism for Dexamethasone (Decadron)
Binds GR, which regulates expression of genes with many effects on carbohydrate metabolism and immune function
33
What are the therapeutics for Dexamethasone (Decadron)
Emergency treatment (severe adrenal crisis, PAI); suppression test (Cushing's); CAH
34
What are the important side effects for Dexamethasone (Decadron)
Cushing's; glucocorticoid-induced osteoporosis; iatrogenic adrenal insufficiency
35
What are the miscellaneous for Dexamethasone (Decadron)
RelAnti-Inflam: 30; RelMin: 0; DoA: 8-12 hours; <1/20 dose of cortisol
36
What is the class for Fludrocortisone
Mineralocorticoid
37
What is the mechanism for Fludrocortisone
Binds aldosterone receptor (AR) which increases Na+K+ATPase expression and increase epithelial sodium channel experession
38
What are the therapeutics for Fludrocortisone
Chronic primary adrenal insufficiency (maintenance); CAH
39
What are the important side effects for Fludrocortisone
Primary aldosteronism
40
What are the miscellaneous for Fludrocortisone
RelAnti-Inflam: 10; RelMin: 125; DoA: 12-36 hours; very small dose
41
What is the mechanism for Aminoglutethide (Cytadren)
Blocks conversion of cholesterol to pregnenolone
42
What are the therapeutics for Aminoglutethide (Cytadren)
Cushing's
43
What is the class for Ketoconazole (Nizoral)
Anti-fungal imidazole derivitive
44
What is the mechanism for Ketoconazole (Nizoral)
Potent, nonselective inhibitor of adrenal and gonadal steroid synthesis
45
What are the therapeutics for Ketoconazole (Nizoral)
Cushing's
46
What is the class for Mitotane (Lysodren)
DDT insecticide relative
47
What is the mechanism for Mitotane (Lysodren)
Nonselective cytotoxic action on adrenal cortex
48
What are the therapeutics for Mitotane (Lysodren)
Cushing's
49
What are the important side effects for Mitotane (Lysodren)
Bad side effect profile
50
What is the mechanism for Metyrapone (Metopirone)
Relatively selective inhibitor of 11-hydroxylation (interferes with cortisol and corticosterone synthesis)
51
What are the therapeutics for Metyrapone (Metopirone)
Cushing's
52
What is the mechanism for Mifepristone (RU-486)
Progesterone receptor antagonist; GR antagonist at high concentrations
53
What are the therapeutics for Mifepristone (RU-486)
Cushing's (controls hyperglycemia secondary to hypercortisolism)
54
What are the important side effects for Mifepristone (RU-486)
Fatigue, nausea, headache, hypokalemia, arthralgias
55
What are the other side effects for Mifepristone (RU-486)
edema and endometrial thickening in women
56
What is the class for Pasireotide
somatostatin analog
57
What is the mechanism for Pasireotide
Binds to somatostatin receptorand blocks release of ACTH from corticotropes
58
What are the therapeutics for Pasireotide
Cushing's
59
What are the important side effects for Pasireotide
Hyperglycemia, GI problems
60
What is the mechanism for Spironolactone (Aldactone)
Aldosterone receptor antagonist
61
What are the therapeutics for Spironolactone (Aldactone)
Primary aldosteronism
62
What are the important side effects for Spironolactone (Aldactone)
Anti-androgenic
63
What is the mechanism for Eplerenone (Inspra)
Aldosterone receptor antagonist
64
What are the therapeutics for Eplerenone (Inspra)
Primary aldosteronism
65
What are the miscellaneous for Eplerenone (Inspra)
More specific; less anti-androgenic effect than spironolactone

Pharm U5 (5 decks)

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