5) Transplant - U5

Question 1

What is the class for ATGAM; ALG; OKT3

Answer 1

Pan T-cell antibodies

Question 2

What is the mechanism for ATGAM; ALG; OKT3

Answer 2

Depletion of T-lymphocytes by inducing complement-mediated cytolysis and cell-mediated opsonization in the spleen and liver

Question 3

What are the therapeutics for ATGAM; ALG; OKT3

Answer 3

Induce immunosuppression to prevent rejection of transplanted organs

Question 4

What are the important side effects for ATGAM; ALG; OKT3

Answer 4

Serum sickness reaction characterized by fevers, chills, tachycardia, hypertension or hypotension, myalgias, and rash

Question 5

What are the other side effects for ATGAM; ALG; OKT3

Answer 5

Pre-disposition to opportunistic infections (long-term)

Question 6

What is the class for Dacluzimab (Zenapax)

Answer 6

IL-2 receptor antibody

Question 7

What is the mechanism for Dacluzimab (Zenapax)

Answer 7

Inhibits IL-2 mediated T-lymphocyte proliferation.

Question 8

What are the therapeutics for Dacluzimab (Zenapax)

Answer 8

Induce immunosuppression to prevent rejection of transplanted organs

Question 9

What are the important side effects for Dacluzimab (Zenapax)

Answer 9

Lower incidence of drug-related adverse reactions than pan T-cell Abs

Question 10

What are the miscellaneous for Dacluzimab (Zenapax)

Answer 10

Discontinued in 2009.

Question 11

What is the class for Basiliximab (Simulect)

Answer 11

IL-2 receptor antibody

Question 12

What is the mechanism for Basiliximab (Simulect)

Answer 12

Inhibits IL-2 mediated T-lymphocyte proliferation.

Question 13

What are the therapeutics for Basiliximab (Simulect)

Answer 13

Induce immunosuppression to prevent rejection of transplanted organs

Question 14

What are the important side effects for Basiliximab (Simulect)

Answer 14

Lower incidence of drug-related adverse reactions than pan T-cell Abs

Question 15

What is the class for Alemtuzimab (Campath)

Answer 15

CD-52 antibody

Question 16

What is the mechanism for Alemtuzimab (Campath)

Answer 16

Supresses both B & T cells to produce a profound lymphopenia

Question 17

What are the therapeutics for Alemtuzimab (Campath)

Answer 17

Induce immunosuppression to prevent rejection of transplanted organs

Question 18

What is the class for Methylprednisilone

Answer 18

Glucocorticoid

Question 19

What is the mechanism for Methylprednisilone

Answer 19

Non-specific anti-inflammatory agent

Question 20

What are the therapeutics for Methylprednisilone

Answer 20

Induce immunosuppression to prevent rejection of transplanted organs; also used for maintenance

Question 21

What are the important side effects for Methylprednisilone

Answer 21

Diabetes mellitus, hyperlipidemia, hypertension, fluid retention, myopathy, osteoporosis, and a predisposition toward opportunistic infections

Question 22

What are the miscellaneous for Methylprednisilone

Answer 22

High dose on day1, then rapid daily taper

Question 23

What is the class for Cyclosporin (Sandimmune)

Answer 23

Calcineurin inhibitor

Question 24

What is the mechanism for Cyclosporin (Sandimmune)

Answer 24

Blocks IL-2 production

Question 25

What are the therapeutics for Cyclosporin (Sandimmune)

Answer 25

Used for maintenance of immunosuppression

Question 26

What are the important side effects for Cyclosporin (Sandimmune)

Answer 26

Renal insufficiency, hypertension, dyslipidemia, metabolic derangements

Question 27

What are the other side effects for Cyclosporin (Sandimmune)

Answer 27

Gingival hyperplasia and hirsutism

Question 28

What are the miscellaneous for Cyclosporin (Sandimmune)

Answer 28

Significant drug interactions with any drug metabolized by CYP3A4

Question 29

What is the class for Tacrolimus (Prograf)

Answer 29

Calcineurin inhibitor

Question 30

What is the mechanism for Tacrolimus (Prograf)

Answer 30

Blocks IL-2 production

Question 31

What are the therapeutics for Tacrolimus (Prograf)

Answer 31

Used for maintenance of immunosuppression

Question 32

What are the important side effects for Tacrolimus (Prograf)

Answer 32

Renal insufficiency, hypertension, dyslipidemia, metabolic derangements

Question 33

What are the other side effects for Tacrolimus (Prograf)

Answer 33

New onset DM; hemolytic-uremic syndrome

Question 34

What are the miscellaneous for Tacrolimus (Prograf)

Answer 34

Significant drug interactions with any drug metabolized by CYP3A4

Question 35

What is the class for Azathioprine (Imuran)

Answer 35

Antimetabolite

Question 36

What is the mechanism for Azathioprine (Imuran)

Answer 36

Inhibits de novo purine synthesis

Question 37

What are the therapeutics for Azathioprine (Imuran)

Answer 37

Used for maintenance of immunosuppression

Question 38

What are the important side effects for Azathioprine (Imuran)

Answer 38

Leukopenia; hepatotoxicity; pancreatic toxicity

Question 39

What is the class for Mycophenolate (Celicept)

Answer 39

Antimetabolite

Question 40

What is the mechanism for Mycophenolate (Celicept)

Answer 40

Inhibits de novo purine synthesis

Question 41

What are the therapeutics for Mycophenolate (Celicept)

Answer 41

Used for maintenance of immunosuppression

Question 42

What are the important side effects for Mycophenolate (Celicept)

Answer 42

Leukopenia (less than azathioprine; GI toxicity

Question 43

What is the class for Sirolimus (Rapamune); Everolimus (Zortress)

Answer 43

mTOR inhibitors

Question 44

What is the mechanism for Sirolimus (Rapamune); Everolimus (Zortress)

Answer 44

Blocks cell cycle progression from G1 to S phase to inhibit T & B cell proliferation

Question 45

What are the therapeutics for Sirolimus (Rapamune); Everolimus (Zortress)

Answer 45

Used for maintenance of immunosuppression

Question 46

What are the important side effects for Sirolimus (Rapamune); Everolimus (Zortress)

Answer 46

Hyperlipidemia, oral ulcerations, impaired wound healing, interstitial pneumonitis

Question 47

What is the mechanism for Belatacept

Answer 47

Blocks co-stimulation of T cells

Question 48

What are the therapeutics for Belatacept

Answer 48

Used for maintenance of immunosuppression

Question 49

What is the class for Rituximab

Answer 49

CD-20 mAb

Question 50

What is the mechanism for Rituximab

Answer 50

Destruction of B cells

Question 51

What are the therapeutics for Rituximab

Answer 51

Combat antibody-mediated rejection after transplatation