10.1 bio Flashcards
(5 cards)
order and events of cell cycle
G1- growth and normal cellular functions, preparation for replication of DNA
S- DNA replication occurs
G2- Cell continues to grow, produces more organelles, proteins, and membranes in preparation for division
M- DNA divides, than the cytoplasm divides
(G0- Cell leaves the cell cycle to rest or differentiate)
examples and roles stimulatory proteins (growth factors, cyclins, cdks)
Growth factors—small proteins that circulate in the bloodstream—stimulate signals inside cells that cause G1-phase cyclin concentrations to rise.
The cyclins bind to the appropriate CDKs, which then phosphorylate other proteins to drive the cell cycle into S phase.
CDK-cyclin complexes signal the cell to duplicate its DNA.
examples and roles of inhibitory proteins (p53)
if DNA is damaged, the p53 protein will stop cell cycle progression until the damage is repaired.
Definitions and examples of proto-oncogenes and tumor suppressor genes
Proto-oncogenes are normal genes that promote cell growth and division, while tumor suppressor genes normally act to inhibit cell growth and prevent uncontrolled cell division.