Dyslipidaemia Flashcards

1
Q

Ezetimibe

A

selective inhibitor of absorption of cholesterol in small bowel
Inhibition of membrane transporter
10mg/day = 20% reduction in LDL C and 8% reduction in TG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

PCSK9 inhibitors

A

Monoclonal antibodies

prevent LDLR degradation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Hypercholesterolaemia

A

Increased TC and LDLC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Mixed hyperlipidaemia

A

Increased TC, LDLC, TG

Decreased HDLC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Hypertriglyceraemia

A

Causes harm through acute pancreatitis
Less common
Familial

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Lipoprotein a

A

Made by liver
LDL like + Apo A + Apo B associated with MI/stroke/aortic stenosis
ApoA. -glycoprotein; atherosclerosis and thrombosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Treatment - lipid apheresis

A

80-90% decrease in CV events

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Anti PCSK9 - efficacy

A

Decrease cholesterol by 25%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Antisense therapy

A

Decreased levels of LP(a) by 90% - small molecules bind to apo (a) mRNA in nucleus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Familial hypercholesteraemia

A

autosomal dominant (mutations in LDLR gene)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly