Dyslipidaemia Flashcards
Ezetimibe
selective inhibitor of absorption of cholesterol in small bowel
Inhibition of membrane transporter
10mg/day = 20% reduction in LDL C and 8% reduction in TG
PCSK9 inhibitors
Monoclonal antibodies
prevent LDLR degradation
Hypercholesterolaemia
Increased TC and LDLC
Mixed hyperlipidaemia
Increased TC, LDLC, TG
Decreased HDLC
Hypertriglyceraemia
Causes harm through acute pancreatitis
Less common
Familial
Lipoprotein a
Made by liver
LDL like + Apo A + Apo B associated with MI/stroke/aortic stenosis
ApoA. -glycoprotein; atherosclerosis and thrombosis
Treatment - lipid apheresis
80-90% decrease in CV events
Anti PCSK9 - efficacy
Decrease cholesterol by 25%
Antisense therapy
Decreased levels of LP(a) by 90% - small molecules bind to apo (a) mRNA in nucleus
Familial hypercholesteraemia
autosomal dominant (mutations in LDLR gene)