Drugs for Hemophilia Flashcards

1
Q

hemophilia

A

a genetic bleeding disorder is seen almost exclusively in males; platelets aggregate correctly, but fibrin formation does not

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2
Q

Hemophilia A:

A

deficiency of clotting factor VIII (aka antihemophilic factor)

6x more prevalent

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3
Q

Hemophilia B:

A

There is a deficiency of clotting factor IX (aka Christmas factor)

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4
Q

Cornerstone of treatment is replacement therapy:

A
Factor VIII (for hemophilia A)
Factor IX (for hemophilia B)

based on prevention

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5
Q

Desmopressin (for mild)

A

Promotes the release of factor VIII

Much cheaper than Factor VIII

med
Disadvantage: can deplete stored factor VIII

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6
Q

Antifibrinolytic drugs:

A

Aminocaproic acid

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7
Q

Pain meds:

A

Acetaminophen or opiates

Avoid NSAIDs and Aspirin

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8
Q

Factor VIII-hemophilia A

A

Recombinant Factor VIII is safer than plasma-derived factor VIII (donor factor), but more expensive.

actual weight is needed to calculate dosage

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9
Q

Factor VIII-hemophilia A

side effects

A
Hives, rash, stuffy nose, fever
GIVE ANTIHISTAMINE (diphenhydramine)
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10
Q

Factor IX-hemophilia B

A

recombinant and donor forms available; Recombinant is safer; IV push at first signs of needs accurate weight

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11
Q

Hemophilia Therapy-Desmopressin

A

Antidiuretic hormone

stop/prevent bleeding w/ mild depression; VIII for HA

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12
Q

Hemophilia Therapy-Desmopressin side effects

A

Fluid retention

Hyponatremia

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