H2 Antagonists and PPIs for PUD and GERD (anti-ulcer)

Question 1

H2 Receptor Antagonists (3)

Answer 1

Cimetidine
Famotidine
Nizatidine

Question 2

H2 Receptor Antagonists (3)

Answer 2

Cimetidine
Famotidine
Nizatidine

Question 3

Proton Pump Inhibitors (6)

Answer 3

Lansoprazole
Dexlansoprazole
Omeprazole
Esomeprazole
Pantoprazole
Rabeprazole

Question 4

Proton Pump Inhibitors (6)

Answer 4

Lansoprazole
Dexlansoprazole
Omeprazole
Esomeprazole
Pantoprazole
Rabeprazole

Question 5

MOA for H2 Receptor Antagonists?

Answer 5

Reversibly (-) H2 receptors on baso-lateral membrane of parietal cells

Question 6

Drug class that (-) H2 receptors on baso-lateral membrane of parietal cells

Answer 6

H2 Receptor Antagonists

Question 7

How quick is the onset for H2 Receptor Antagonists?

Answer 7

Pretty quick - 0.5-2 hours

= longer than antacids but shorter than PPIs

Question 8

Common adverse effects of H2 Receptor Antagonists?

Answer 8

Primarily GI-related

Some CNS-related

Question 9

RARE adverse effects of H2 Receptor Antagonists?

Answer 9

Neutropenia and Thrombocytopenia
Decreased testosterone binding to androgen receptor
== > Gynecomastia in males and Galactorrhea in females

Question 10

Which H2 Receptor Antagonist has the potential to cause Gynecomastia in males and Galactorrhea in females and why?

Answer 10

Cimetidine

- Decreases Testosterone binding to androgen receptor

Question 11

Which H2 Receptor Antagonist is a prototypical inhibitor of several CYP450 enzyme?

Answer 11

Cimetidine

Question 12

Cimetidine has _____ of drug-drug interactions. Why?

Answer 12

LOTS

- Inhibits CYP450 enzymes

Question 13

Relative contraindications for H2 Receptor Antagonists?

Answer 13

Pregnancy

Question 14

MOA for Proton Pump Inhibitors?

Answer 14

Bind to Sulfhydryl groups of H+/K+ ATPase at parietal cell secretory sites
= (-) pumps and gastric acid secretion

Question 15

Drug class that binds and inhibits H+/K+ ATPase on parietal cell secretory sites

Answer 15

Proton Pump Inhibitor

Question 16

Proton Pump Inhibitors stop ____ secretion from parietal cells

Answer 16

Gastric acid secretion

Question 17

How long does it take to see the effects of Proton Pump Inhibitors?

Answer 17

A few days

Question 18

Common adverse effects of Proton Pump Inhibitors?

Answer 18

Primarily GI-related

Some CNS-related

Question 19

RARE adverse effect of Proton Pump Inhibitors?

Answer 19

CDAD

- Clostridiodes Difficile - Associated Diarrhea

Question 20

What drug class can cause CDAD (Clostridiodes Difficile - Associated Diarrhea)?

Answer 20

Proton Pump Inhibitors

Question 21

Which Proton Pump Inhibitor is a prototypical inhibitor of CYP450?

Answer 21

Omeprazole

Question 22

Omeprazole has ___ of drug-drug interactions. Why?

Answer 22

Lots

- Inhibits CYP450 enzymes

Question 23

2 anti-ulcer drugs that have lots of drug-drug interactions because they inhibit CYP450 enzymes?

Answer 23

Cimetidine

Omeprazole

Question 24

Relative Contraindications for Proton Pump Inhibitors?

Answer 24

Pregnancy

Question 25

List the Proton Pump Inhibitors.

Answer 25

Lansoprazole
Dexlansoprazole
Omeprazole
Esomeprazole
Pantoprazole
Rabeprazole

Question 26

List the H2 Receptor Antagonists.

Answer 26

Cimetidine
Famotidine
Nizatidine

Question 27

Relative Contraindications for H2 receptor antagonists and Proton Pump (-)?

Answer 27

Pregnancy

Question 28

What is an isomer for the PPI Lansoprazole?

Answer 28

Dexlansoprazole

Question 29

What is an isomer for the PPI Omeprazole?

Answer 29

Esomeprazole

Question 30

Which PPIs have isomers?

Answer 30

Lansoprazole

Omeprazole