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GI - 2 > Agents for IBD - specific applications > Flashcards

Agents for IBD - specific applications Flashcards

1
Q

ASA

A

Acetylsalicylic Acid – Aspirin

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2
Q

What do 5-ASA drugs substitute?

A

Amine at position 5 of ASA

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3
Q

Which drugs in the 5-ASA class are metabolized to Mesalamine (5-ASA)?

A

Sulfsalazine
Olsalazine
Balsalazide

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4
Q

Sulfapyridine + 5-ASA

A

Sulfsalazine

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5
Q

Single 5-ASA

A

Mesalamine

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6
Q

2 molecules of 5-ASA

A

Olsalazine

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7
Q

Inlet carrier and 5-ASA

A

Balsalazide

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8
Q

MOA for 5-ASA drugs

A

(-) cyclooxygenase and (-) lipoxygenase

==> (-) prostaglandin and leukotrienes production

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9
Q

This class of drugs (-) cyclooxygenase and (-) lipoxygenase to ultimately (-) prostaglandin and leukotriene production

A

5-ASA class

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10
Q

There are fewer side effects with ____ 5-ASA products (NON____)

A

Fewer side effects with PURE 5-ASA

– NONsulfsalazine

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11
Q

The adverse effects with the 5-ASA group are usually GI and CNS related. When are these drugs contraindicated?

A
  • ALL drugs are contraindicated in patients allergic to ASA

- Sulfsalazine is contraindicated in patients allergic to sulfonamide

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12
Q

5-ASA members are indicated for _____ ulcerative colitis

A

Mild-Moderate

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13
Q

Olsalazine is only used for?

A

Maintenance of remission of ulcerative colitis

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14
Q

Balsalazide is only used for?

A

Active disease of ulcerative colitis

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15
Q

This 5-ASA drug is only used for maintenance of remission of ulcerative colitis?

A

Olsalazine

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16
Q

This 5-ASA drug is only use for active disease of ulcerative colitis?

A

Balsalazide

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17
Q

5-ASA members are indicated for ______ ulcerative colitis

A

Mild-Moderate

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18
Q

MOA for Tofacitinib?

A

(-) free floating and bound JAK-1 and JAK-3

=> stops pro-inflammatory gene transcription and more cytokine release

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19
Q

MOA for Tofacitinib?

A

(-) free floating and bound JAK-1 and JAK-3

=> stops pro-inflammatory gene transcription and more cytokine release

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20
Q

Possible adverse effects of Tofacitinib?

A
  • Lymphopenia/Lymphocytosis
  • Neutropenia/Anemia
  • Increased LDL/HDL
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21
Q

This drug can potentially cause Lymphopenia/Lymphocytosis, Neutropenia/Anemia, and increased LDL/HDL

A

Tofacitinib

22
Q

Tofacitinib is NOT recommended for use with other?

A

Biologic therapies or immunosuppressants

23
Q

Tofacitinib is NOT recommended for use with other?

A

Biologic therapies or immunosuppressants

24
Q

Tofacitinib is indicated for _____ ulcerative colitis

A

Moderate-Severe

25
Q

Tofacitinib is indicated for _____ ulcerative colitis

A

Moderate-Severe

26
Q

Besides ulcerative colitis, what else can Tofacitinib treat?

A

Psoriatic and Rheumatoid arthritis

27
Q

MOA for Ustekinumab

A

Bind to P40 subunit of IL-12/23 to (-) activation/differentiation of naive T cells and NK cells

28
Q

MOA for Ustekinumab

A

Bind to P40 subunit of IL-12/23 to (-) activation/differentiation of naive T cells and NK cells

29
Q

Adverse effects of Ustekinumab?

A

INFECTIONs

30
Q

Adverse effects of Ustekinumab?

A

INFECTIONs

31
Q

What is recommended pre-therapy for Ustekinumab?

A

TB testing

32
Q

Ustekinumab is indicated for ______ ulcerative colitis and crohn’s disease

A

Moderate-Severe

33
Q

Ustekinumab is indicated for ______ ulcerative colitis and crohn’s disase

A

Moderate-Severe

34
Q

MOA for TNF-alpha inhibitors?

A

Binds and neutralizes TNF-alpha

==> blocks pro-inflammatory signaling and leukocyte migration

35
Q

MOA for TNF-alpha inhibitors?

A

Binds and neutralizes TNF-alpha

==> blocks pro-inflammatory signaling and leukocyte migration

36
Q

TNF-alpha inhibitors are given via SQ injection except for?

A

Infliximab = IV

37
Q

TNF-alpha inhibitors are given via SQ injection except for?

A

Infliximab = IV

38
Q

Adverse effects of TNF-alpha inhibitors?

A

INFECTIONs
Malignancies
Liver toxicity

39
Q

Adverse effects of TNF-alpha inhibitors?

A

INFECTIONs
Malignancies
Liver toxicity

40
Q

What is recommended pre-therapy for TNF-alpha inhibitors?

A

TB testing

41
Q

TNF-alpha inhibitors are indicated for ______ ulcerative colitis/crohn’s disease

A

Moderate-Severe

42
Q

TNF-alpha inhibitors are indicated for ______ ulcerative colitis/crohn’s disease

A

Moderate-Severe

43
Q

MOA for Alpha-4 integrin inhibitors

A

(-) integrin associated cell adhesion and migration of leukocytes to inflammation site

44
Q

MOA for Alpha-4 integrin inhibitors?

A

(-) integrin associated cell adhesion and migration of leukocytes to inflammation site

45
Q

Adverse effects of Alpha-4 integrin inhibitors?

A

Infections

PML with Natalizumab

46
Q

Adverse effects of Alpha-4 integrin inhibitors?

A

Infections

PML with Natalizumab

47
Q

What are 3 risk factors for acquiring PML (progressive multifocal leukoencephalopathy) when using Natalizumab?

A
  • Treatment > 2 years
  • Prior immunosuppressant use
  • Anti-JC virus antibodies
48
Q

What are 3 risk factors for acquiring PML (progressive multifcoal leukoencephalopathy) when using Natalizumab?

A
  • Treatment > 2 years
  • Prior immunosuppressant use
  • Anti-JC virus antibodies
49
Q

What drug/class can potentially cause PML?

A

Natalizumab/Alpha-4 integrin inhibitor

50
Q

What drug classes require TB testing before therapy?

A

IL-12/23 inhibitors

TNF-alpha inhibitors

GI - 2 (61 decks)

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